TARGETED

作品数：1083被引量：3093H指数：24
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Construction and characterization of intestinal oligopeptide transporter PepT1-targeted polymeric micelles for enhanced intestinal absorption of poorly water-soluble agents被引量：1
《Journal of Chinese Pharmaceutical Sciences》2019年第8期561-570,共10页Yao Jin Qi Liu Chuhang Zhou Shidi Han Yuanhang Zhou Xinping Hu Leqi Wang Yan Liu 
National Natural Science Foundation of China(Grant No.81673366);the National Key Science Research Program of China(973 Program,Grant No.2015CB932100)
To overcome the main barrier of intestinal epithelium for the oral absorption of poorly water-soluble drugs and further improve their oral absorption, Gly-Sar, the substrate of the oligopeptide transporter PepT1 widel...
关键词：Intestinal transporter Oligopeptide transporter PepT1 Gly-Sar Polymeric micelles Oral administration 
Preparation and characterization of intestinal transporter-targeted polymeric micelles被引量：2
《Journal of Chinese Pharmaceutical Sciences》2018年第7期490-497,共8页Chuyu He Yao Jin Yunqiang Deng Yang Zou Shidi Han Chuhang Zhou Yuanhang Zhou Xinru Li Yanxia Zhou Yan Liu 
The National Natural Science Foundation of China(Grant No.81673366);the National Key Science Research Program of China(973 Program,Grant No.2015CB932100)
The intestinal epithelium is the main barrier to the oral delivery of poorly water-soluble drugs. Based on the specific transporters expressed on the apical membrane of the intestinal epithelium, novel polymer micelle...
关键词：CARNITINE Organic cation transporter 2 （OCTN2） Polymeric micelles In vitro release Intestinal absorption 
Preparation and characterization of intestine PepT1-targeted calcium carbonate nanoparticles被引量：4
《Journal of Chinese Pharmaceutical Sciences》2018年第6期397-407,共11页Yunqiang Deng Yao Jin Chuyu He Yang Zou Yuanhang Zhou Shidi Han Chuhang Zhou Qi Liu Xinru Li Yanxia Zhou Yan Liu 
The National Natural Science Foundation of China(Grant No.81673366);the National Key Science Research Program of China(973 Program,Grant No.2015CB932100)
To improve the oral absorption of poorly water-soluble drugs by overcoming the intestinal epithelium barrier, calcium carbonate nanoparticles targeting to intestine peptide transporter 1（Pep T1） were fabricated by m...
关键词：Calcium carbonate nanoparticles Oligopeptide transporter Gly-Sar In vitro release Intestinal absorption 
Targeted and imaging-guided in vivo photodynamic therapy for tumors using dual-function, aggregation- induced emission nanoparticles被引量：1
《Nano Research》2018年第5期2756-2770,共15页Xianhe Sun Abudureheman Zebibula Xiaobiao Dong Gonghui Li Guanxin Zhang Deqing Zhang Jun Qian Sailing He 
This work was supported by the National Basic Research Program of China （973 Program） （Nos. 2013CB834704 and 2011CB503700）, the National Natural Science Foundation of China （NSFC） （No. 11621101）, and the Science and Technology Department of Zhejiang Province （No. 2010R50007）
Imaging-guided photodynamic therapy （PDT） has been regarded as a promising strategy for precise cancer treatment. Because of their excellent modifiability and drug-loading capacity, nanoparticles have played an impo...
关键词：aggregation-induced emission targeted therapy imaging-guided therapy photodynamic therapy tumor 
Vapreotide-modified nanomicelle as a targeted nanocarrier for delivering paclitaxel to the tumors with overexpression of somatostatin receptors
《Journal of Chinese Pharmaceutical Sciences》2015年第8期501-513,共13页Wenjie Hou Hua Zheng Jiancheng Wang 
National Basic Research Program of China(973 Program,Grant No.2013CB932501);NSFC projects(Grant No.81273455 and 81473158);Programs from Ministry of Education(Grant No.NCET-11-0014 and BMU20110263)
Somatostatin receptors （SSTRs） were widely expressed in many tumor cells. As a somatostatin analogue, vapreotide （VAP） can be exploited as a modifier for targeting tumor therapy based on its high affinity to SSTR....
关键词：Somatostatinreceptor Vapreotide Targeted nanomicelle PACLITAXEL Tumor therapy 
Zooplankton community analysis in the Changjiang River estuary by single-gene-targeted metagenomics被引量：1
《Chinese Journal of Oceanology and Limnology》2014年第4期858-870,共13页程方平 王敏晓 李超伦 孙松 
Supported by the National Natural Science Foundation of China(No.41230963);the National Basic Research Program of China(973 Program)(No.2011CB403604);the"135"Fund of Institute of Oceanology,Chinese Academy of Sciences(No.2012I0060102);the Innovative Research Group Funding of the National Natural Science Foundation of China(No.41121064);the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDA11020305)
DNA barcoding provides accurate stages. Single-gene-targeted metagenomic analysis identification of zooplankton species through all life based on DNA barcode databases can facilitate long- term monitoring of zooplankt...
关键词：ZOOPLANKTON DNA barcodes cytochrome oxidase subunit 1 （coxl） 
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