Traumatic brain injury(TBI)is a significant public health issue,affecting approximately 1.7 million people annually in the United States alone,with over 5 million experiencing long-term disabilities(Roozenbeek et al.,...
FEDER Prostem Research Project,No.1510614(Wallonia DG06);the F.R.S.-FNRS Epiforce Project,No.T.0092.21;the F.R.S.-FNRS Cell Squeezer Project,No.J.0061.23;the F.R.S.-FNRS Optopattern Project,No.U.NO26.22;the Interreg MAT(T)ISSE Project,which is financially supported by Interreg France-Wallonie-Vlaanderen(Fonds Européen de Développement Régional,FEDER-ERDF);Programme Wallon d’Investissement Région Wallone pour les instruments d’imagerie(INSTIMAG UMONS#1910169);support from the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation programme(AdG grant agreement no.834317,Fueling Transport,PI Frédéric Saudou)。
Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary injury.Withi...
supported by the National Natural Science Foundation of China, Nos. 82271411 (to RG), 51803072 (to WLiu);grants from the Department of Finance of Jilin Province, Nos. 2022SCZ25 (to RG), 2022SCZ10 (to WLiu), 2021SCZ07 (to RG);Jilin Provincial Science and Technology Program, No. YDZJ202201ZYTS038 (to WLiu);The Youth Support Programmed Project of China-Japan Union Hospital of Jilin University, No. 2022qnpy11 (to WLuo);The Project of China-Japan Union Hospital of Jilin University, No. XHQMX20233 (to RG)
Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely studied.However,their inability to cross the blood–brain barrier hampers the clinical translation of these...
supported by the Jiangsu Province Science and Technology Support Project(No.:BE2023769)。
Vasculature injury occurs rarely in traumatic brain injury but increases lifetime risk of ischemic or hemorrhage stroke.The diverse and nonspecific clinical manifestations make the diagnosis and treatment of these inj...
supported by NIH grants NS084967,NS121037 (to AEK) and NS110609 (to COB)。
Traumatic brain injury(TBI) impacts 69 million individuals globally each year and is a leading cause of death and disability(Dewan et al.,2019).The majority of moderate-to-severe TBI survivors endure long-lasting dist...
supported in part by the grants from the National Natural Science Foundation of China[grant numbers 81771176 for Zhao Y,82150710558 and 82151308 for Chen JF];by the Startup Funds from the Oujiang Laboratory (the Zhejiang Provincial Key Laboratory for Regenerative Medicine and Eye-Brain Disorders)[grant number OJQDSP2022007 for Chen JF]Wenzhou,China。
Adenosine exerts its dual functions of homeostasis and neuromodulation in the brain by acting at mainly 2 G-protein coupled receptors,called A1 and A2A receptors.The adenosine A2A receptor(A2AR)antagonists have been c...
supported by National Institutes of Health grants RF1NS076815 and R01AG058621.
Currently,more than 55 million people have dementia worldwide and Alzheimer’s disease(AD)is one of the most common causes of dementia in aging.However,no effective therapies are currently available for the prevention...
Objective To explore the effect of nerve injury in rats by neurobehavioral experiments,in order to provide a model and idea for further clarification of the traumatic brain injury mechanism under explosion exposure.Me...
Although there are challenges in treating traumatic central nervous system diseases,mesenchymal stem cell-de rived extracellular vesicles(MSC-EVs) have recently proven to be a promising non-cellular the rapy.We compre...
This study was partly supported by the National Natural Science Foundation of China(91949203 to Zhang Y.Z.,82102627 to Lv X.);Key Project of Hebei Provincial Natural Fund(H2020206456);Hubei Provincial Natural Science Foundation of China(2021CFB095);Wuhan Knowledge Innovation Project 2022020801020468.
Traumatic brain injury(TBI)accelerates fracture healing,but the underlying mechanism remains largely unknown.Accumulating evidence indicates that the central nervous system(CNS)plays a pivotal role in regulating immun...