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作品数:656被引量:1797H指数:16
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The epigenetic mechanisms underlying gamete origin of adult-onset diseases被引量:3
《Science Bulletin》2022年第17期1724-1727,共4页Guolian Ding Bin Chen John R.McCarrey Hefeng Huang 
supported by the National Natural Science Foundation of China(82088102);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-5-064);Collaborative Innovation Program of Shanghai Municipal Health Commission(2020CXJQ01);Clinical Research Plan of Shanghai Hospital Development Center(SHDC2020CR1008A);Shanghai Frontiers Science Research Base of Reproduction and Development;Zhejiang Provincial Natural Science Foundation of China(LQ21H040005)。
The events occurring before and soon after birth appear to impact an individual’s health throughout adulthood significantly.The pioneering work of David J.P.Barker studied the nutritional status of 2414 pregnant wome...
关键词:成人疾病 CARDIOVASCULAR DISEASES 
Molecular mechanism underlying the subtype-selectivity of competitive inhibitor NF110 and its distinct potencies in human and rat P2X3 receptors被引量:2
《Science Bulletin》2018年第24期1616-1625,共10页Bin Li Jin Wang Xiaoyang Cheng Yan Liu Yang Yang Xiaona Yang Changrun Guod Youya Niu Peng Cao Xiangyang Lu Michael X.Zhu Yun Tian Ye Yu 
supported by the National Natural Science Foundation of China(31570832);the National Program on Key Basic Research Project of China(2014CB9103000/02);Science and Technology Department of Hunan Province(2018RS3086);National Postdoctoral Program for Innovative Talents(BX201700306);China Postdoctoral Science Foundation(2018M632127);the Hunan Provincial Natural Science Foundation(2017JJ2198,2018JJ1012);Guangxi Funds for Distinguished Experts
P2X receptors are a family of extracellular ATP-gated trimeric cation channels that is widely distributed in human tissues. Quite some drug candidates targeting P2X receptors have entered into preclinical or main phas...
关键词:P2X RECEPTORS COMPETITIVE inhibitors NF110 Species-specificity Subtype-selectivity 
Initial exploration of the mechanism underlying H2O2-induced root horizontal bending in pea被引量:2
《Science Bulletin》2015年第14期1298-1300,共3页Sheng Li Li-Rong Su Shao-Ying Ma Zhen-Zhen Shi Xiao-Ming Yang 
supported by the National Natural Science Foundation of China(31160304);Gansu Provincial Key Laboratory of Aridland Crop Science,Gansu Agricultural University,China
It was reported that exogenous hydrogen peroxide (H2O2) can induce primary root bend in Arabidopsis and pea. However, the mechanism remains unclear. Here we explored the mechanism underlying this phenomenon by using...
关键词:GRAVITROPISM Exogenous H2O2Horizontal bending Primary pea root 
Methods for mapping QTLs underlying endosperm traits based on random hybridization design被引量:7
《Chinese Science Bulletin》2006年第16期1976-1981,共6页WEN Yongxian WU Weiren 
Several methods of interval mapping of QTLs underlying endosperm traits based on random hybridization designs and the triploid genetic model are proposed. The basic idea is: plants (or lines) from a population with kn...
关键词:胚乳 QTLS 随机杂化设计 遗传模型 
NEURO-COGNITIVE MECHANISMS UNDERLYING THE EMOTIONAL MODULATION OF WORD READING被引量:12
《Chinese Science Bulletin》2006年第4期377-384,共8页PENG Danling HU Zhiguo LIU Hongyan LIU Conghui DING Guosheng 
A novel neural model for emotional modulation of word reading is proposed. This model has four principal hypotheses: the dominant activa-tion region hypothesis, the emotional modulation hypothesis, the attentional lev...
关键词:文字阅读 情绪调节 认知机制 神经模型 注意力 
A new statistical method for mapping QTLs underlying endosperm traits被引量:8
《Chinese Science Bulletin》2005年第14期1470-1476,共7页HU Zhiqiu XU Chenwu 
supported by the National Natural Science Foundation of China(Grant Nos.39900080,30270724&30370758).
Genetic expression for an endosperm trait in seeds of cereal crops may be controlled simultaneously by the triploid endosperm genotypes and the diploid maternal genotypes. However, current statistical methods for mapp...
关键词:胚乳特性 遗传因子 遗传模型 染色体 
Possible developmental mechanisms underlying the origin of the crown lineages of arthropods被引量:2
《Chinese Science Bulletin》2004年第1期49-53,共5页WANGXiuqiang CHENJunyuan 
The extraordinarily preserved, diverse arthropod fauna from the Lower Cambrian Maotianshan shale,central Yunnan (southwest China), represents different evolutionary stages stepping from stem lineages towards crown art...
关键词:节肢动物 寒武纪 云南 解剖学 
Regulation of angiotensin Ⅱ on Gαq/11 protein of vascular smooth muscle cell and its underlying mechanism被引量:1
《Chinese Science Bulletin》2002年第16期1369-1372,共4页XING Dongqi, BAI Hua, ZHAO Yali & WU LilingDepartment of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China 
This work was supported by the National Natural Science Foundation of China (Grant Nos. 30170379 and 39870356).
To study the regulation of angiotensin Ⅱ (Ang Ⅱ) on Gαq/11 protein of vascular smooth muscle cell (VSMC) and its underlying mechanism, the protein synthesis was detected by [3H]-leucine incorporation. Gαq/11 expre...
关键词:ANGIOTENSIN II vascular smooth muscle cell G PROTEIN HYPERTROPHY signal transduction. 
ON ALSPACH'S PROBLEM FOR BIPARTITE TOURNAMENTS
《Chinese Science Bulletin》1990年第9期784-784,共1页王建中 
An oriented graph is a digraph without loops, multiple arcs or cycles of length 2. Let D=(V, A) be an oriented graph of the order p, where V and A denote the set of vertices and the set of arcs of D, respectively. Ass...
关键词:INTEGER directed LENGTH VERTEX LETTER UNLESS UNDERLYING 
EFFICIENCY OF M:N MATCHING IN CASE-CONTROL STUDIES
《Chinese Science Bulletin》1988年第11期966-967,共2页廖建岗 田凤调 
In case-control studies, controls are often more readily obtained than cases so it makes sense to have the control-case ratio larger than 1. In case-control design, for the basic form of one dichtomous risk factor, we...
关键词:MATCHING CASE readily bringing arbitrary desirable UNDERLYING LETTER SOMETIMES RETURN 
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