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ALTERED: 作品数：454被引量：1290H指数：16; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：何少琴张标薛仁镐陈璐璐袁莉更多>>; 相关机构：华中科技大学上海医科大学哈佛医学院首都医科大学附属北京安定医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders: 《Neural Regeneration Research》2025年第8期2302-2303,共2页Asma Boulksibat Alessandra Tempio Barbara Bardoni; The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular processes.In the brain,these p...; 关键词：formation processes finally

Safety evaluation after LASIK surgery based on the linear creep property:a finite element analysis: 《International Journal of Ophthalmology(English edition)》2025年第5期889-896,共8页Ji-Xi Guo Xue-Feng Li Xin-Chao Wang Xin-Heng Zhao Yan Wang Li-Hua Fang; Supported by National Natural Science Foundation of China(No.62165010);The National Key Research and Development Program of China(No.2022YFC2404502).; AIM:To investigate the effect of the percent tissue altered(PTA)on the safety after laser-assisted in situ keratomileusis(LASIK)based on linear creep characteristics.METHODS:The linear creep characteristics of the cor...; 关键词：laser-assisted in situ keratomileusis finite element percent tissue altered vertex displacement

Altered microbiota of rectal mucosa in rectal cancer patients: 《World Journal of Gastroenterology》2025年第13期22-35,共14页Hao Zhang Yan Zhou You-Heng Jiang Wan-Ping Hu Lu-Lu Huang Hai-Xia Lin Zhi-Gui Zuo Ji-Mei Du Yong-Liang Lou; Supported by the Medical and Health Research Project of Zhejiang Province,No.2023KY998.; BACKGROUND With advances in sequencing techniques,microbiota dysbiosis and pathogenic microbes that accelerate colorectal cancer progression have been identified and widely reported.However,few studies have focused on...; 关键词：Rectal cancer Mucosal-associated microbiota Gut microbiota GENOMICS Predictive biomarkers

Atmospheric CO_(2) Removal Efficiency through Enhanced Silicate Weathering in Croplands:A Review with Emphasis on the Contribution of Fungi: 《Journal of Earth Science》2025年第1期197-211,共15页Zi-Bo Li Gaojun Li Jonathan M.Adams Dong-Xing Guan Liang Zhao Rongjun Bian Qing Hu Xiancai Lu Junfeng Ji Jun Chen; funded by the National Natural Science Foundation of China(Nos.42173059 and 41991322)。; Enhanced silicate weathering(ESW)is a geoengineering method aimed at accelerating carbon dioxide(CO_(2))removal(CDR)from atmosphere by increasing the weathering flux of silicate rocks and minerals.It has emerged as a ...; 关键词：enhanced weathering carbon dioxide removal efficiency FUNGI weathering rate altered surface layers

Corrigendum: Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism: 《Neural Regeneration Research》2025年第2期401-401,共1页; In the article titled“Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism,”published on pages 650-656,Issue 3,Volum...; 关键词：METABOLISM ENDOTHELIN

Structurally altered size,composition,shape and interfacedependent optical properties of quantized nanomaterials: 《Nano Research》2024年第12期10543-10569,共27页Neng Qin Hui Han Guijian Guan Ming-Yong Han; supported by the National High Technology Research and Development Program of China(No.2021YFF1200200);the Peiyang Talents Project of Tianjin University.; The impact of the size effect on the color and photoluminescence(PL)of quantum dots(QDs)has sparked a revolutionary field of research,culminating in the prestigious Nobel Prize in 2023.Prior to their widespread popula...; 关键词：NANOCLUSTERS quantum dots size effect composition effect optical property chiral characteristics

Corrigendum to‘How ligand coordination and superatomic-statesaccommodate the structure and property of a metal cluster:Cu4(dppy)_(4)Cl_(2)vs.Cu_(21)(dppy)_(10)with altered photoluminescence’[Chin.Chem.Lett.35(2024)108340]: 《Chinese Chemical Letters》2024年第12期568-568,共1页Haiming Wu Gaya N.Andrew Rajini Anumula Zhixun Luo; The original version of this article unfortunately missed the link of Supplementary Material which contains the single crystal structure(CCDC 2131877)and data details.We are sorry for any inconvenience caused.DOI of o...; 关键词：structure property cluster

Altered flow and sediment transport impacts on the ecosystems of Chinese major rivers:An urgent call for eco-fluvial dynamics: 《River》2024年第4期341-361,共21页Hongwei Fang Guojian He Lei Huang Chenwei Zhao Jianyu Wang Yong Han Qifeng Gao Tao Zhang Jianan Meng; National Key Research and Development Program of China,Grant/Award Number:2022YFC3201803;National Natural Science Foundation of China,Grant/Award Numbers:12272209,U2040214。; River ecosystems face challenges due to environmental degradation and alterations in flow and sediment transport resulting from climate change and other anthropogenic impacts.These changes may substantially affect riv...; 关键词：eco-fluvial dynamics ecosystem health assessment flow and sediment transport river ecosystems

First-in-human,phase 1 dose-escalation and dose-expansion study of a RET inhibitor SY-5007 in patients with advanced RET-altered solid tumors: 《Signal Transduction and Targeted Therapy》2024年第12期5641-5651,共11页Wei Li Yongsheng Wang Anwen Xiong Ge Gao Zhengbo Song Yiping Zhang Dingzhi Huang Feng Ye Qiming Wang Zhihui Li Jiaye Liu Chunwei Xu Yinghui Sun Xijie Liu Fei Zhou Caicun Zhou; supported by Shouyao Holdings(Beijing)Co.,Ltd,Beijing,China.; Oncogenic RET alteration is an important,tissue-agnostic therapeutic target across diverse cancers.We conducted a first-in-human phase 1 study on SY-5007,a potent and selective RET inhibitor,in patients with RET-alter...; 关键词：PATIENTS alterations EXPANSION

Pancreatic agenesis and altered m6A methylation in the pancreas of PDX1-mutant cynomolgus macaques: 《Zoological Research》2024年第6期1188-1200,共13页Wen-Hui Zhang Jiong-Han Zhuang Yun-Yi Guo Xue-Ying Chen Ya-Qing Li Jie-Qiu Xu An-Ran Zhang Bao-Yi Chen Wei Meng Yan-Hua Zhu Jun-Jiu Huang Yong-Long Guo Shi-Hua Yang; supported by the National Key R&D Program of China(2018YFA0801404,2023YFC3403400);National Natural Science Foundation of China(81941006,32371190,32370878);Guangdong Special Support Program(2019BT02Y276,2024A1515012868);Double First-Class Discipline Promotion Project(2023B10564003);Program for Scientific Research Start-up Funds of Guangdong Ocean University(060302052408)。; As an essential transcriptional activator,PDX1 plays a crucial role in pancreatic development andβ-cell function.Mutations in the PDX1 gene may lead to type 4 maturityonset diabetes of the young(MODY4)and neonatal di...; 关键词：PDX1 MODY4 Cynomolgus macaques M6A methylation modification

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