supported by 973 program (2012CB911102 CS);National Megaproject for Innovative Drugs (2012ZX09301002-001-015 and 2012ZX09301002-005-002 CS);National Mega-Project for Infectious Disease (2013ZX1000 4601-002 CS);The National Natural Science Foundation of China (81271844 ZJM and 31470272 CS)
Human APOBEC3G(h A3G) is a cytidine deaminase which inhibits HIV-1 replication. The HIV-1 accessory protein viral infectivity factor(Vif) counteracts with hA3G by targeting it for proteasomal degradation. In this work...
part by 973 program(2012C B911102);the National S&T Major Special Project on Major New Drug Innovation(2012ZX09102101-018);the National S&T International Collaboration 2010DFA31580(J.D.J.)and 2010DFB30870(Q.J.).
APOBEC3G(A3G)is a host cytidine deaminase that incorporates into HIV-1 virions and efficiently inhibits viral replication.The virally encoded protein Vif binds to A3G and induces its degradation,thereby counteracting ...
National Grand Fundamental Research 973 Program of China (2006CB504206).
Interaction between the HIV-1 Vif protein and the cellular host APOBEC3G protein is a promising target for inhibition of HIV-1 replication. Considering that human cells are a very complicated environment for the study...