CHRYSIN

作品数：23被引量：129H指数：7
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相关领域：医药卫生更多>>
相关作者：张永煜更多>>
相关机构：北里大学沈阳药科大学中山医学大学彦臣生技药品股份有限公司更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《Acta Biochimica et Biophysica Sinica》《Chinese Herbal Medicines》《Cellular & Molecular Immunology》更多>>
相关基金：国家自然科学基金国家教育部博士点基金天津市自然科学基金广东省自然科学基金更多>>
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3D Printed Chitosan Bioink Loaded with Chrysin for Repairing Bone Defects
《Chemical Research in Chinese Universities》2025年第1期155-164,共10页ZHANG Hao TANG Wenshuo SUI Xin LI Lingfeng ZHANG Hongpu LI Yuran ZHANG Xueyi LIU Zhihui WANG Bowei 
supported by the National Natural Science Foundation of China(No.82370934);the Project of the Graduate Innovation Fund of Jilin University,China(No.2024CX143);the Science and Technology Development Plan Project of Jilin Province,China(No.20230204076YY).
This study aimed to investigate the potential of chrysin(C)to induce osteogenic differentiation of rat bone marrow mesenchymal stem cells(BMSCs)in vitro.Chitosan(CS)was dissolved by repeated freeze-thawing of alkali/u...
关键词：CHRYSIN CHITOSAN Bioscaffold 3D printing HYDROXYAPATITE 
Design,synthesis,and biological evaluation of novel chrysin derivatives as poly(ADP-ribose)polymerase 1(PARP1)inhibitors for the treatment of breast cancer
《Chinese Journal of Natural Medicines》2024年第5期455-465,共11页YANG Yao TONG Jing XIE Xianshun CAO Hong FU Yong LUO Yong LIU Shan CHEN Wen YANG Ning 
This work was supported by the Clinical Research Center for Breast&Thyroid Disease Prevention in Hunan Province(No.2018SK4001);the Scientific Research Project of Hunan Provincial Health Commission(No.20201969)。
In this study,we reported the discovery and structure-activity relationship analysis of chrysin derivatives as a new class of inhibitors targeting poly(ADP-ribose)polymerase 1(PARP1).Among these derivatives,compound 5...
关键词：Chrysin derivatives PARP1 Antitumor DNA damage Small molecules 
Pyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer
《Signal Transduction and Targeted Therapy》2024年第1期295-307,共13页Xiaoxiao Liu Xing Zhang Zhiying Shao Xiaorong Zhong Xin Ding Liang Wu Jie Chen Ping He Yan Cheng Kunrui Zhu Dan Zheng Jing Jing Ting Luo 
supported by the Sichuan Provincial Department of Science and Technology,International Cooperation in Science and Technology Innovation with Hong Kong,Macao,and Taiwan(2023YFH0095);1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC21035);Beijing Xislike Clinical Oncology Research Foundation(Y-HR2020MS-1031);Beijing Science and Technology Innovation Medical Development Foundation(KC2021-JF-0167-13);Key Research and Development Program of Xuzhou(KC20115)。
Human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC)has been the most challenging subtype of BC,consisting of 20%of BC with an apparent correlation with poor prognosis.Despite that pyrotinib,a new...
关键词：HER2 SYNERGISTIC TOGETHER 
Potential therapeutic activities and novel delivery systems of chrysin-a nature’s boon
《Food Bioscience》2022年第1期52-64,共13页Shreya Chitrakant Adangale Sarika Wairkar 
Flavonoids are a diverse group of phytonutrients that have gained attention as dietary supplements due to their broad spectrum of therapeutic properties and negligible side effects.Chrysin,a 5,7-dihydroxyflavone,has b...
关键词：CHRYSIN FLAVONOIDS Poor bioavailability Delivery systems Improved therapeutic activity 
Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma(ESCC)被引量：3
《Acta Pharmaceutica Sinica B》2021年第1期143-155,共13页Jie Cheny Yan Wangy Di Zhao Lingyuan Zhang Weimin Zhang Jiawen Fan Jinting Li Qimin Zhan 
supported by the National Natural Science Foundation of China(81830086,81988101,81772504 and 81972243);Beijing Municipal Commission of Health and Family Planning Project(PXM2018_026279_000005,China)
Among current novel druggable targets,proteineprotein interactions(PPIs)are of considerable and growing interest.Diacylglycerol kinase a(DGKα)interacts with focal adhesion kinase(FAK)band 4.1-ezrin-radixin-moesin(FER...
关键词：CHRYSIN Esophageal squamous cell carcinoma DGKα FAK Proteineprotein interactions 
Synthesis and anti-tumor activities of novel 7-O-amino acids chrysinderivatives
《Chinese Herbal Medicines》2018年第3期323-330,共8页Ding Liu Yan-peng Li Hong-xiu Shen Yang Li Jun He Qi-zhi Zhang Yun-mei Liu 
supported by Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study(No.2014-405);Hunan Provincial Department of Education Project(14C1003)
Objective: To design and synthesize a series of chrysin derivatives and evaluate the antitumor activities with MTT assay, so as to investigate molecular structure-activity relationship with molecular docking.Methods: ...
关键词：amino-acid chrysin derivatives ANTI-TUMOR molecular docking SYNTHESIS 
Effects of Inclusion of Chrysin in Cucurbit[8]uril on Its Stability, Solubility and Antioxidant Potential被引量：2
《Chemical Research in Chinese Universities》2017年第5期736-741,共6页XU Zhiling LIAN Xiaowei LI Mengjie ZHANG Xiaodong WANG Yi TAO Zhu ZHANG Qianjun 
Supported by the National Natural Science Foundation of China（No.21272045）.
The host-guest interaction between cucurbit[8]uril（Q[8]） and chrysin（CHR） has been studied by means of 1H NMR, mass spectrometry（MS）, differential thermal analysis（DTA）, and UV-Vis spectrophotometry. The resul...
关键词：CHRYSIN CUCURBIT[8]URIL hMusion complex SOLUBILITY STABILITY Antioxidant activity 
Chrysin ameliorates podocyte injury and slit diaphragm protein loss via inhibition of the PERK-elF2α-ATF-CHOP pathway in diabetic mice被引量：11
《Acta Pharmacologica Sinica》2017年第8期1129-1140,共12页Min-Kyung KANG Sin-Hye PARK Yun-Ho KIM Eun-Jung LEE Lucia Dwi ANTIKA DongYeon KIM Yean-Jung CHOi Young-Hee KANG 
Iomerular epithelial podocytes are highly specialized cells that play a crucial role in maintaining normal function of the glomerular Itration barrier via their foot processes. Chrysin （5,7-dihydroxyflavone） is a n...
关键词：chyrsin flavonoid diabetic nephropathy podocyte apoptosis endoplasmic reticulum stress slit diaphragm protein 
Preventive effect of chrysin on experimental autoimmune uveitis triggered by injection of human IRBP peptide 1-20 in mice被引量：3
《Cellular & Molecular Immunology》2017年第8期702-711,共10页Xiangda Meng Sijie Fang Zhuhong Zhang Yang Wang Caiyun You Jingkai Zhang Hua Yan 
supported by the National Natural Science Foundation of China(grant numbers 81371038 and 91442124);the Natural Science Foundation of Tianjin(grant 12JCYBJC33900 and 14JCYBJC28000);TMUGH(grant number ZYYFY2015026).
Uveitis is a common cause of blindness worldwide.Experimental autoimmune uveitis(EAU)is an animal model of noninfectious uveitis.Chrysin(5,7-dihydroxyflavone)is a member of the flavonoid family and has anti-inflammato...
关键词：blood-retinal barrier CHRYSIN experimental autoimmune uveitis NF-ΚB T helper-cell subsets 
Synthesis of New 7-O-Modified Chrysin Derivatives and Their Anti-proliferative and Apoptotic Effects on Human Gastric Carcinoma MGC-803 Cells被引量：1
《Chemical Research in Chinese Universities》2014年第6期925-930,共6页LIU Yunmei SONG Xiudao MA Jin HE Jun ZHENG Xing LEI Xiaoyong JIANG Guorong ZHAO Zihao PAN Xia 
Two series of 7-O-modified chrysin derivatives were prepared from 7-O-carboxymethy! chrysin（2a）, 7-O-carboxypropylchrysin（2b） and short-chain alcohols by using 1-ethyl-3-（3-dimethylaminopropyl）carbodiimide hydro...
关键词：7-O-Modified chrysin Anti-proliferative effect Apoptotic effect Flavanoid 
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