CORONAVIRUS

作品数：670被引量：1624H指数：19
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相关机构：广州市第八人民医院中国医学科学院基础医学研究所遵义医科大学外高桥出入境检验检疫局更多>>
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Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation被引量：5
《Signal Transduction and Targeted Therapy》2022年第10期3940-3954,共15页Ting Gao Lin Zhu Hainan Liu Xiaopeng Zhang Tingting Wang Yangbo Fu Hongzhen Li Qincai Dong Yong Hu Zhang Zhang Jing Jin Zijing Liu Weihong Yang Yaoning Liu Yanwen Jin Kaitong Li Yongjiu Xiao Junli Liu Huailong Zhao Yue Liu Ping Li Jibo Song Lu Zhang Yuwei Gao Sisi Kang Shoudeng Chen Qingjun Ma Xiuwu Bian Wei Chen Xuan Liu Qing Mao Cheng Cao 
funded by the National Science and Technology Major Projects(2018ZX09711003-005-005 and 2018ZX09201017-007);the National Basic Research Program of China(2012CB518902).
Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses,but the underlying mechanism remains unclear.In this study,the N proteins of highly pathogenic hum...
关键词：LUNG INFLAMMATION activation 
Assessment of respiratory support decision and the outcome of invasive mechanical ventilation in severe COVID-19 with ARDS被引量：1
《Journal of Intensive Medicine》2022年第2期92-102,共11页Shuhan Cai Fangfang Zhu Hongtao Hu Hui Xiang Dawei Wang Jing Wang Lu Li Xiao Yang Aihua Qin Xin Rao Yun Luo Jianguo Li Kianoush B.Kashani Bo Hu Zhiyong Peng 
supported by the Chinese Medical Information and Big Data Association(Bo Hu,No.Z-2019-1-003);the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(Bo Hu,No.ZNJC202011);the key project of the Ministry of Science and Technology of China(Zhiyong Peng,No.2020YFC0841300).
Background:The coronavirus disease 2019(COVID-19)is an ongoing pandemic.Invasive mechanical ventilation(IMV)is essential for the management of COVID-19 with acute respiratory distress syndrome(ARDS).We aimed to assess...
关键词：COVID-19 Acute respiratory distress syndrome(ARDS) Respiratory support decision Invasive mechanical ventilation Severe acute respiratory coronavirus 2 (SARS-CoV-2) 
Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites被引量：26
《Acta Pharmaceutica Sinica B》2020年第7期1228-1238,共11页Sisi Kang Mei Yang Zhongsi Hong Liping Zhang Zhaoxia Huang Xiaoxue Chen Suhua He Ziliang Zhou Zhechong Zhou Qiuyue Chen Yan Yan Changsheng Zhang Hong Shan Shoudeng Chen 
supported by National Natural Science Foundation of China(31770801);Special Fund for Scientific and Technological Innovation Strategy of Guangdong Province of China(2018B030306029 and 2017A030313145);National Natural Science Foundation of China(81430041,81620108017);National Key Basic Research Program,China(SQ2018YFC090075);National Natural Science Foundation of China(81870019)
The outbreak of coronavirus disease(COVID-19)caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths.Currently,there is no specific viral protein-targeted therapeutics.Viral nucleocapsid p...
关键词：COVID-19 CORONAVIRUS SARS-CoV-2 Nucleocapsid protein RNA binding domain Crystal structure Antiviral targeting site 
Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus-related coronavirus model被引量：20
《Chinese Medical Journal》2020年第9期1051-1056,共6页Hua-Hao Fan Li-Qin Wang Wen-Li Liu Xiao-Ping An Zhen-Dong Liu Xiao-Qi He Li-Hua Song Yi-Gang Tong 
This work was supported by a project from Ministry of Science and Technology of China(No.2020YFC0840805);Key Project of Beijing University of Chemical Technology(No.X K 1803-06),Fundamental Research Funds for Central Universities(No.BUCTRC201917),and a.start-up funding for Dr.Yi-Gang Tong from Beijing Advanced Innovation Center for Soft Matter Science and Engineering.
Background:Medicines for the treatment of 2019-novel coronavirus(2019-nCoV)infections are urgently needed.However,drug screening using live 2019-nCoV requires high-level biosafety facilities,which imposes an obstacle ...
关键词：Coronavirus disease 2019 2019-Novel coronavirus CEPHARANTHINE SELAMECTIN Mefloquine hydrochloride 
Genetic and antigenic characterization of recombinant nucleocapsid proteins derived from canine coronavirus and canine respiratory coronavirus in China被引量：2
《Science China(Life Sciences)》2016年第6期615-621,共7页Shuai Lu Yingzhu Chen Kun Qin Jianfang Zhou Yongliang Lou Wenjie Tan 
supported by the Mega project for Infectious Disease Research of China (2014ZX10004001-002, 2013ZX10004601);National Basic Research Program of China (2011CB504704)
To characterize the antigenicity of nucleocapsid proteins(NP) derived from canine coronavirus(CCo V) and canine respiratory coronavirus(CRCo V) in China, the N genes of CCo V(CCo V-BJ70) and CRCo V(CRCo V-BJ202) were ...
关键词：canine coronavirus canine respiratory coronavirus nucleocapsid protein expression cross-reactivity 
Coronavirus MHV-A59 infects the lung and causes severe pneumonia in C57BL/6 mice被引量：9
《Virologica Sinica》2014年第6期393-402,共10页Zhangsheng Yang Jun Du Gang Chen Jie Zhao Xuanming Yang Lishan Su Genhong Cheng Hong Tang 
supported in part by grants from the Natural Science Foundation of China (30430640,31030031);the National Basic Research Program of MOST (2004BA519A61,2003CB514116,2006CB504300);Natural Science Foundation of China (31400765)
It remains challenging to develop animal models of lung infection and severe pneumonia by severe acute respiratory syndrome coronavirus(SARS-CoV) and Middle East respiratory syndrome cornavirus(MERS-Co V) without high...
关键词：CORONAVIRUS MHV-A59 PNEUMONIA INFLAMMATION CYTOKINE 
人冠状病毒 NL63中国株的全基因组克隆与序列分析
《中华微生物学和免疫学杂志》2014年第6期411-416,共6页耿合员 崔丽瑾 陆柔剑 赵莉 谭文杰 
国家重点基础研究发展计划（973计划）（2011CB504704）;科技重大专项十二五计划（2013ZX10004601,2011ZX10004-001）
目的：对来自北京儿童医院的两份人冠状病毒NL63（human coronavirus NL63， HCoV-NL63）阳性样本进行病毒全基因组序列测定和分析。方法以荷兰株（NL63_Amsterdam 1）为参考株，设计18对包含重叠区域的、覆盖全长基因组的引物，采用病...
关键词：HCOV-NL63 全基因组测序 系统发生分析 Human CORONAVIRUS NL 63 
The structural and accessory proteins M,ORF 4a,ORF 4b,and ORF 5 of Middle East respiratory syndrome coronavirus(MERS-CoV)are potent interferon antagonists被引量：25
《Protein & Cell》2013年第12期951-961,共11页Yang Yang Ling Zhang Heyuan Geng Yao Deng Baoying Huang Yin Guo Zhengdong Zhao Wenjie Tan 
This work was supported by the National Basic Research Program(973 Program)(No.2011CB504704);the Ministry of Health of China(2014ZX10004-001,2013ZX10004601).
The newly emerged Middle East respiratory syndrome coronavirus(MERS-CoV)is a highly pathogenic respira-tory virus with pathogenic mechanisms that may be driven by innate immune pathways.The goal of this study is to ch...
关键词：MERS-CoV structural proteins accessory proteins interferon antagonists 
The newly emerged SARS-Like coronavirus HCoV-EMC also has an “Achilles’ heel”: current effective inhibitor targeting a 3C-like protease被引量：11
《Protein & Cell》2013年第4期248-250,共3页Zhilin Ren Liming Yan Ning Zhang Yu Guo Cheng Yang Zhiyong Lou Zihe Rao 
supported by the National Basic Research Program(973 Program);National Natural Science Foundation of China.
From the global outbreak of SARS-CoV caused infection disease in 2003,coronaviruses(CoVs)are known to be a great threat to the human health.Recently,a new SARS-like coronavirus,human betacoronavirus 2c EMC/2012(HCoV-E...
关键词：EMC SARS Together 
Structures of the N- and C-terminal domains of MHV-A59 nucleocapsid protein corroborate a conserved RNA-protein binding mechanism in coronavirus被引量：3
《Protein & Cell》2010年第7期688-697,共10页Yanlin Ma Xiaohang Tong Xiaoling Xu Xuemei Li Zhiyong Lou Zihe Rao 
supported by the National Natural Science Foundation of China(Grant No.30730022);the National Basic Research Program(973 Program)(Grant No.2006CB806503);the National Programs for High Technology Research and Development Program(863 Program)(Grant Nos.2006AA02A322 and 2006AA020502);the National Major Project(Grant No.2009ZX10004-304);the Chinese Academy of Sciences Grant KSCX2-YW-R-05 to Z.R.
Coronaviruses are the causative agent of respiratory and enteric diseases in animals and humans.One example is SARS,which caused a worldwide health threat in 2003.In coronaviruses,the structural protein N(nucleocapsid...
关键词：crystal structure nucleocapsid protein murine hepatitis virus 
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