CEPHARANTHINE

作品数：8被引量：45H指数：3
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相关期刊：《Chinese Medical Journal》《广西医科大学学报》《Acta Pharmacologica Sinica》《Medicine in Novel Technology and Devices》更多>>
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N-glycoproteomic profiling revealing novel coronavirus therapeutic targets potentially involved in Cepharanthine's intervention
《Medicine in Novel Technology and Devices》2022年第4期95-102,共8页Wenlin An Fengjuan Tian Jing Li Junge Chen Yigang Tong 
the National Key Research and Development Program of China(2018YFA0903000);the National Natural Science Foundation of China(81672001);China MoST Emergency Project on COVID-19(2020YFC0840800);Guangdong Basic and Applied Basic Research Foundation(2021A1515110619);the Fundamental Research Funds for the Central Universities(KG16052901).
The Coronavirus disease 2019(COVID-19)has posed a serious threat to global health and the world economy.Antiviral therapies targeting coronavirus are urgently required.The Cepharanthine(CEP)is a traditional Chinese he...
关键词：CEPHARANTHINE CORONAVIRUS N-GLYCOSYLATION SARS-CoV-2 Viral pathogenesis 
Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis被引量：1
《Acta Pharmacologica Sinica》2022年第1期177-193,共17页Li-wen Shen Xiu-xing Jiang Zhi-qiang Li Jie Li Mei Wang Guan-fei Jia Xin Ding Ling Lei Qi-hai Gong Ning Gao 
This work was supported by the National Natural Science Foundation of China(31571425;82004009);the grant from the“Hundred”Level of High-level Innovative Talents in Guizhou Province(QKHRCPT20165684);the Science and Technology Plan Program of Guizhou Province(2018,5772-071).We thank James Bamburg(University of Wisconsin)for providing Cofilin-WT and site mutant plasmids of cofilin(Cofilin-S3A and Cofilin-S3E).
Inhibition of autophagy has been accepted as a promising therapeutic strategy in cancer,but its clinical application is hindered by lack of effective and specific autophagy inhibitors.We previously identified cepharan...
关键词：triple negative breast cancer CEPHARANTHINE EPIRUBICIN mitochondrial superoxide oxidative stress COFILIN mitochondrial fission APOPTOSIS 
Reversal of Tetracycline Resistance by Cepharanthine,Cinchonidine,Ellagic Acid and Propyl Gallate in a Multi-drug Resistant Escherichia coli
《Natural Products and Bioprospecting》2021年第3期345-355,共11页Darko Jenic Helen Waller Helen Collins Clett Erridge 
This work was supported by an Erasmus+Mobility Studentship(ref DK KOBENHA 57)awarded to DJ.The funder was not involved in the interpretation of results or writing of the article.
Bacterial resistance to antibiotics is an increasing threat to global healthcare systems.We therefore sought compounds with potential to reverse antibiotic resistance in a clinically relevant multi-drug resistant isol...
关键词：Antibiotic resistance Natural products PHYTOCHEMICAL SCREENING Efflux pump inhibitor 
Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus-related coronavirus model被引量：20
《Chinese Medical Journal》2020年第9期1051-1056,共6页Hua-Hao Fan Li-Qin Wang Wen-Li Liu Xiao-Ping An Zhen-Dong Liu Xiao-Qi He Li-Hua Song Yi-Gang Tong 
This work was supported by a project from Ministry of Science and Technology of China(No.2020YFC0840805);Key Project of Beijing University of Chemical Technology(No.X K 1803-06),Fundamental Research Funds for Central Universities(No.BUCTRC201917),and a.start-up funding for Dr.Yi-Gang Tong from Beijing Advanced Innovation Center for Soft Matter Science and Engineering.
Background:Medicines for the treatment of 2019-novel coronavirus(2019-nCoV)infections are urgently needed.However,drug screening using live 2019-nCoV requires high-level biosafety facilities,which imposes an obstacle ...
关键词：Coronavirus disease 2019 2019-Novel coronavirus CEPHARANTHINE SELAMECTIN Mefloquine hydrochloride 
Cepharanthine enhance radiosensitization of nasopharyngeal carcinoma cells through inhibition of DNA damage repair
《广西医科大学学报》2018年第2期141-145,共5页Mengya Zhang Tianjun Ma Qingfeng Song Huixia Lin Wei Xiao Meiqi Zhao XinQing Liang Ying Cui 
supported by the National Natural Science Foundation of China (No. 30660203);the National Science and Technology Major Project (No. 2013ZX10002009);the Key laboratory of High- Incidence Tumor Prevention (Guangxi Medical University),Ministry of Education(No. GK2015-ZZ06)
Objective: Recent reports suggest that Cepharanthine(CEP),a natural alkaloid extracted from the roots of Stephania Cepharanthine Hayata,can inhibit the proliferation of various cancer cells,but few studies focus on it...
关键词：《广西医科大学学报》 期刊 编辑工作 发行工作 
Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer被引量：1
《中国药理学与毒理学杂志》2017年第10期997-998,共2页Zheng-hai TANG Wen-xiang CAO Xia GUO Xiao-yang DAI Jia-hong LU Xiu-ping CHEN Hong ZHU Jin-jian LU 
supported by Science and Technology Development Fund,Macao S.A.R(FDCT)(024/2016/A1);Research Fund of University of Macao(MYRG2015-00091-ICMS-QRCM and MYRG2015-00101-ICMS-QRCM)
OBJECTIVE Identification of novel autophagy inhibitors for the combinational treatment of non-small cell lung cancer(NSCLC).METHODS MTT assay and annexin V/PI staining assay were used to evaluate the cell proliferatio...
关键词：CEPHARANTHINE non-small cell lung cancer AUTOPHAGY LYSOSOME dacomitinib 
Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells被引量：14
《Acta Pharmacologica Sinica》2012年第1期101-108,共8页ZanChen  ChenHuang  Yan-lingYang  YiDing  Han-qiangOu-Yang  You-yiZhang MingXu 
Aim： To investigate the molecular mechanisms underlying the antitumor activity of cepharanthine （CEP）, an alkaloid extracted from Stephania cepharantha Hayata. Methods： Human osteosarcoma cell line SaOS2 was used....
关键词：CEPHARANTHINE anticancer drug human osteosarcoma cell SaOS2 cell cycle arrest apoptosis STAT3 nude mice 
Antiviral activity of cepharanthine against severe acute respiratory syndrome coronavirus in vitro被引量：11
《Chinese Medical Journal》2005年第6期493-496,共4页ZHANGChuan-hai WANGYi-fei LIUXin-jian LUJia-hai QIANChui-wen WANZhuo-yue YANXin-ge ZHENGHuan-ying ZHANGMei-ying XIONGSheng LIJiu-xiang QIShu-yuan 
ThisresearchwassupportedbygrantsfromtheScienceFoundationofGuangdongProvince(No.2003C50301,and2004E039213).
Severe acute respiratory syndrome(SARS) is the first severe viral epidemic we encountered his century,which once spread in more than thirty countriesin2003.1 The etiological agent of SARS has beenc onfirmed to be a n...
关键词：CEPHARANTHINE severe acute respiratory syndrome CORONAVIRUS antiviral activity 
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