We sincerely apologize to all colleagues whose important work could not be cited in this review owing to space limitations,especially many prominent and pioneer work in the cGAS/cGAMP/STING field.This work was supported by an NIH grant(R01CA244825,P.L.);the Breast Cancer Alliance Young Investigator Grant(P.L.);the Gabrielle's Angel Foundation Medical Research Award(P.L.);the UNC University Cancer Research Fund(P.L.).
Sensing invasive cytosolic DNA is an integral component of innate immunity.cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special asymmetric cyclic-dinucl...
The authors wish to thank the companies of the INNTER ECOSANVID 2015 project(FEDER-CDTI,EXP:00093497/ITC-20151026):DCOOP-BACO,FINCA ANTIGUA,VIALCON,NUTRICONTROL who provide the mature plants for this study.
Grapevine trunk diseases (GTDs) are currently one of the most important problems for grapevine plant and wine industry, causing important economic cost in Castilla-La Mancha, Spain. Traditionally, GTDs were associated...
The Special Programme for Research and Training in Tropical Diseases(TDR)hosted at the World Health Organization(WHO)funded the VERDAS research Consortium,for“VEctor boRne DiseAses Scoping reviews”.
Background:Vector-borne diseases(VBDs)continue to represent a global threat,with“old”diseases like malaria,and“emergent”or“re-emergent”ones like Zika,because of an increase in international trade,demographic gro...