DNA-BINDING

作品数：62被引量：206H指数：6
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Novel synthetic 9-benzyloxyacridine analogue as both tyrosine kinase and topoisomerase I inhibitor被引量：5
《Chinese Chemical Letters》2013年第8期677-680,共4页Xu-Liang Lang Qin-Sheng Sun Yu-Zong Chen Lu-Lu Li Chun-Yan Tan Hong-Xia Liu Chun-Mei Gao Yu-Yang Jiang 
supports from the Ministry of Science and Technology of China(Nos. 2012ZX09506001-010,2012AA020305 and 2011DFA30620);the National Natural Science Foundation of China(Nos.21272134 and 20902053);Shenzhen Sci & Tech Bureau(No. JCYJ20120831165730905)
Multi-target agents against tyrosine kinases and topoisomerases are potentially useful for the effective treatment of cancers.Discovery of new multi-target scaffolds are important for developing such agents. A series ...
关键词：Acridine Topoisomerases Tyrosine kinases Antitumor DNA-binding 
Potent in vitro Interference of Fleroxacin in DNA-binding,Unwinding and ATPase Activities of Bloom Helicase被引量：2
《Biomedical and Environmental Sciences》2013年第4期231-242,共12页LUO Heng XU Hou Qiang CHEN Xiang DING Mei YANG Qi Xin LI Kun 
supported by the National Basic Research Program of China (No.2010CB534912);the Doctoral Program of the Ministry of Education (No.200806570003);the Governor of Guizhou Province Talents Fund (No.200822);Guizhou University innovation fundsfor graduate student (No. Nongke 2012027)
Objective To study the effect of fleroxacin （FLRX） on biological properties of Bloom （BLM） helicase catalytic core （BLM 642-2290 helicase） in vitro and the molecular mechanism of interaction between the two mol...
关键词：Biological activity BLM helicase FLEROXACIN Interaction mechanism 
Synthesis, DNA-binding and photocleavage studies of ruthenium(Ⅱ) complexes [Ru(btz)_3]^(2+) and [Ru(btz)(dppz)_2]^(2+)被引量：4
《Science China Chemistry》2009年第9期1504-1511,共8页YU HuiJuan, HUANG ShuMei, KOU JunFeng, LI LvYing, JIA HaiNa, CHAO Hui & JI LiangNian MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China 
Supported by the 973 Program of China (Grant No 2007CB815306);the National Natural Science Foundation of China (Grant Nos 20771105 & 20871122);the Pro-gram for New Century Excellent Talents in University (Grant No NCET-06-0718);the Key Project (Grant No 108103) of Ministry of Education;the Natural Sci-ence Foundation of Guangclong Province (Grant No 9351027501000003)
Two new ruthenium(Ⅱ) complexes, [Ru(btz)3](ClO4)2 (1) and [Ru(btz)(dppz)2](ClO4)2 (2) (btz = 4,4′-bithi-azole, dppz = dipyrido[3,2-a:2′,3′-c]phenazine), have been synthesized and characterized by elemental analysi...
关键词：ruthenium(Ⅱ) complex DNA binding DNA PHOTOCLEAVAGE PDT 
Effect of thermal injury on LPS-mediated Toll signaling pathways by murine peritoneal macrophages:inhibition of DNA-binding of transcription factor AP-1 and NF-κB and gene expression of c-fos and IL-12p40
《Science China(Life Sciences)》2002年第6期613-622,共10页王兴宇 李昌麟 张劲松 冯卫国 苏踊跃 张宗梁 
This work was supported by the Ministry of Science and Technology of China
Thermal injury is able to induce the immune functional inhibition in the host, but the mechanisms are largely unknown. The available evidence indicates that macrophages play an important role in immune regulations and...
关键词：thermal injury  AP-1  NF-кB  macrophages. 
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