DNA_DAMAGE

作品数：397被引量：1149H指数：14
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Dynamic analysis of DNA damage induced miRNAs in colon cancer cells被引量：4
《Chinese Science Bulletin》2014年第19期2254-2265,共12页Weimin Zhang Fang Yang Qimin Zhan 
supported by the National Natural Science Foundation of China(81021061)
It is known that microRNAs(miRNAs)expression profile shows substantial changes in cells under DNA damage.Here,we did miRNA microarray and quantitative real-time PCR to comprehensively identify the differentially expre...
关键词：miRNA DNA损伤 癌细胞 结肠癌 诱导 WNT信号通路 P53基因 MAPK途径 
Clustered DNA damage induced by protons radiation in plasmid DNA被引量：1
《Chinese Science Bulletin》2013年第26期3217-3223,共7页SUI Li WANG Yu WANG Xiao KONG FuQuan LIU JianCheng ZHOU PingKun 
supported by the National Science Foundation for Distinguished Young Scholars of China (30825011);the National Natural Science Foundation of China (10805078)
Clustered DNA damage is considered as a critical type of lesions induced by ionizing radiation, which can be converted into the fatal or strong mutagenic complex double strand breaks (DSBs) during damage processing in...
关键词：DNA损伤 质粒DNA 辐射诱导 质子比 集群 DNA双链断裂 电离辐射 数据显示 
DNA Damage, Signaling and Repair: Protecting genomic integrity and reducing the risk of human disease被引量：8
《Chinese Science Bulletin》2011年第30期3119-3121,共3页ZHOU PingKun Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing 100850, China Special Topic Editor 
DNA is the genetic material that contains the 'instructions' to not only guide the continuation of life but also govern the development, metabolism and functioning of living organisms. DNA damage occurs daily due to v...
关键词：DNA损伤 基因组 伤信号 人类疾病 整性 修复 风险 保护 
DNA damage stress induces the dissociation of Smurf1/2 from MDM2 in a slow manner被引量：2
《Chinese Science Bulletin》2011年第30期3155-3161,共7页NIE Jing LIU Lin ZHAO XiaoHang XIE Ping ZHOU PingKun XING GuiChun LIU XiangJun HE FuChu HAN WeiDong ZHANG LingQiang 
supported by the National Natural Science Foundation of China (31100554, 30800177);the National Basic Research Program of China (2007CB914601, 2011CB910802)
The tumor suppressor p53 locates at the key point of cell growth or apoptosis balance, and the expression level of p53 is tightly controlled by ubiquitin ligases including MDM2. Upon DNA damage stresses, p53 was accum...
关键词：DNA损伤 MDM2 应激反应 蛋白 解离 泛素连接酶 细胞凋亡 诱导 
Chk1 prevents abnormal mitosis of S-phase HeLa cells containing DNA damage被引量：2
《Chinese Science Bulletin》2009年第22期4205-4213,共9页LI XiaoFang WARD Tarsha YAO XueBiao WU JiaRui 
Supported by the National Key Basic Research and Development Program of China (Grant No. 2006CB503900);National Natural Science Foundation of China (Grant No. 30821065)
To explore effects of DNA damage on cell-cycle progression in p53-deficient tumor cells, synchronized HeLa cells at G1, S and G2/M phases were treated with methyl methanesulfnate (MMS). The results showed that the MMS...
关键词：HeLa细胞 有丝分裂 CHK1 DNA 损伤 S期 异常 
ATM acts in DNA damage signal transduction by catalyzing protein phosphorylation
《Chinese Science Bulletin》1999年第19期1790-1794,共5页Xiangbing Meng Yan Dong Zhixian Sun 
In order to investigate ATM in mediating DNA damage signal to p53 in the cellular response to IR, kinase activities of ATM and c-Abl immunoprecipitates and its activation by IR and damaged DNA have been analyzed. Resu...
关键词：ATM C-ABL p53 PROTEIN phosphorylatton. 
Phenomenon and mechanism of "secondary damage" during repair of DNA damage in irradiated mammalian cells
《Chinese Science Bulletin》1998年第11期921-925,共5页Luo Ying Sun Zhixian Wu Zuze 
ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina (GrantNo .39470 799)
By means of comet assay, a study of kinetics curve of DNA damage repair in irradiated SX-9 cells that came from mouse breast cancer proceeded. It was found that while the initial DNA damages had nearly been repaired, ...
关键词：DNA DAMAGE REPAIR 'secondary damage' poly(ADP-ribose) polymerase. 
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