DNA_DAMAGE

作品数：401被引量：1154H指数：14
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相关机构：东北师范大学首都师范大学上海交通大学医学院附属新华医院浙江林学院更多>>
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Correlation of IGF2 levels with sperm quality,inflammation,and DNA damage in infertile patients
《Asian Journal of Andrology》2025年第2期204-210,共7页Jing-Gen Wu Cai-Ping Zhou Wei-Wei Gui Zhong-Yan Liang Feng-Bin Zhang Ying-Ge Fu Rui LiFang Wu Xi-Hua Lin 
supported by grants from the National Natural Science Foundation of China(No.82370846);the Zhejiang Provincial Natural Science Foundation of China(No.LY24H070002).
Insulin-like growth factor 2(IGF2)is a critical endocrine mediator implicated in male reproductive physiology.To investigate the correlation between IGF2 protein levels and various aspects of male infertility,specific...
关键词：ASTHENOSPERMIA DNA damage IGF2 INFLAMMATION sperm quality teratospermia 
Fat mass and obesity-associated protein in mesenchymal stem cells inhibits osteoclastogenesis via lnc NORAD/miR-4284 axis in ankylosing spondylitis
《World Journal of Stem Cells》2025年第3期28-43,共16页Wen-Jie Liu Jia-Xin Wang Quan-Feng Li Yun-Hui Zhang Peng-Fei Ji Jia-Hao Jin Yi-Bin Zhang Zi-Hao Yuan Pei Feng Yan-Feng Wu Hui-Yong Shen Peng Wang 
Supported by Guangdong Provincial Clinical Research Center for Orthopedic Diseases,No.2023B110001;the Excellent Medical Innovation Talent Program of the Eighth Affiliated Hospital of Sun Yat-sen University,No.YXYXCXRC202101;the National Natural Science Foundation of China,No.82172349,No.82372372,No.22105229,No.32170708,No.82102530,No.82102541,No.82103098,No.82103909,No.82104182,No.82104350,No.82170427,No.82171291,No.82172215,No.82172385,and No.82302661;Guangdong Natural Science Foundation,No.2023A1515010568 and No.2021A1515111057;Shenzhen Science and Technology Program,No.JCYJ20220530144201004 and No.RCBS20210609104445097;and Futian Healthcare Research Project,No.FTWS2022022,No.FTWS2021013,No.FTWS2023072,and No.FTWS2022047.
BACKGROUND Ankylosing spondylitis(AS)is recognized as a long-term inflammatory disorder that leads to inflammation in the spine and joints,alongside abnormal bone growth.In previous studies,we reported that mesenchyma...
关键词：Ankylosing spondylitis Mesenchymal stem cells OSTEOCLASTOGENESIS Fat mass and obesity-associated protein Non-coding RNA activated by DNA damage 
DNA damage triggers heritable alterations in DNA methylation patterns in Arabidopsis
《Molecular Plant》2025年第3期501-512,共12页Jinchao Li Wenjie Liang Xin-Qiang He Weiqiang Qian 
supported by the National Natural Science Foundation of China(grant no.32270288 to W.Q.;grant no.32400245 to J.L.);the China Postdoctoral Science Foundation(2024M760519 to W.L.);the Beijing Life Science Academy(2024500CA0010 to W.Q.).
It has been hypothesized that DNA damage has the potential to induce DNA hypermethylation,contributing to carcinogenesis in mammals.However,there is no sufficient evidence to support that DNA damage can cause genome-w...
关键词：DNA methylation RDDM DREAM DNA damage base excision repair 
Total Phenolic and Flavonoid Contents of Cymbocarpum widemannii and Their Antioxidant, Antimicrobial, DNA Damaging Activities
《Phyton-International Journal of Experimental Botany》2025年第3期781-791,共11页Mehmet Fidan Behcet Inal Mesut Sırrı Bülent Hallaç Ulutas Mehmet Sefa 
The use of conventional herbal medicines is a rapidly expanding phenomenon in developed nations. For instance, 30%–50% of all drug use in China is attributed to traditional herbal preparations. Current study evaluate...
关键词：ANTIOXIDANT ANTIMICROBIAL DNA damage C.wiedemannii 
Material basis revelation of anti-hepatoma effect of Huachansu(Cinobufacini)through down-regulation of thymidylate synthase
《Chinese Herbal Medicines》2025年第1期127-138,共12页Qi Wu Qimei Chen Jingyi Yang Jiayu Zhang Ailin Yang 
financially supported by National Natural Science Foundation of China Grant(No.82204693);Taishan scholar engineering youth expert program of Shandong Province(No.tsqn202103110);Young and Creative Team for Talent Introduction of Shandong Province(No.10073004);Binzhou Medical University Scientific Research Fund for High-level Talents(NO.BY2020KYQD13,2019KYQD06);Standard study on Chinese medicinal materials and Decoction pieces in Shandong Province(No.2020-201)。
Objective:Hepatocellular carcinoma(HCC)is a leading cause of mortality worldwide.Huachansu(Cinobufacini)is active extract isolated from the dry skin of Bufo Bufo gargarizans.It has now been widely used in clinical tre...
关键词：DNA damage hepatocellular carcinoma Huachansu(Cinobufacini) material basis thymidylate synthase proteasomal degradation 
Cryopreservation of bovine sperm causes single‑strand DNA breaks that are localized in the toroidal regions of chromatin
《Journal of Animal Science and Biotechnology》2025年第1期92-106,共15页Jordi Ribas‑Maynou Rodrigo Muiño Carolina Tamargo Marc Yeste 
Ministry of Science,Innovation and Universities,Spain(NextGeneration EU funds;María Zambrano Program 124/MTAI/22;and PID2020-113320RB-I00);Agency for Management of University and Research Grants,Regional Government of Catalonia,Spain(2021-SGR-00900);Catalan Institution for Research and Advanced Studies(ICREA).
Background Sperm cryopreservation is widely used in the cattle industry,as it allows for disassociating the localiza-tion of sires and the collection of semen from the timing of artificial insemination.While freeze-th...
关键词：Cattle DNA damage Fertility Sperm Toroid linker regions 
Changes in the Mechanical Environment of the Nucleus with Cell Crowding and Its Effects on DNA Damage Resistance
《Journal of Biosciences and Medicines》2025年第1期230-242,共13页Kazuaki Nagayama Yuto Hirooka 
Nuclear DNA, which is essential for the transmission of genetic information, is constantly damaged by external stresses and is subsequently repaired by the removal of the damaged region, followed by resynthesis of the...
关键词：Cell Biomechanics MECHANOBIOLOGY Mechanical Properties DNA Damage γ-H2A.X 
Dietary administration of probiotic Bacillus coagulans and Mentha piperita can protect histological architecture and DNA damage in Catla catla(Hamilton,1822)
《Aquaculture and Fisheries》2024年第6期948-956,共9页Sonal Saluja Anita Bhatnagar 
sincerely thankful to HSCST-JRF(HSCST-2301)for fellowship.
The present experimental investigation was executed to evaluate the combined effect of probiotic bacterium Bacillus coagulans along with herb Mentha piperita on histological architecture;and extent of DNA damage after...
关键词：Bacillus COMET HEPATOCYTES HISTOLOGICAL MENTHA 
Enhancing the radiosensitivity of colorectal cancer cells by reducing spermine synthase through promoting autophagy and DNA damage
《World Journal of Gastrointestinal Oncology》2024年第12期4716-4727,共12页Yu-Bin Guo Yue-Ming Wu Zhi-Zhao Lin 
Supported by National Natural Science Foundation of China,No.82102996;Guangdong Provincial Natural Science Foundation,No.2022A1515010517;Guangzhou Science and Technology Plan Project,No.202201011016;President Foundation of Nanfang Hospital,Southern Medical University,No.2020C038.
BACKGROUND Colorectal cancer(CRC),the third most common cancer worldwide,has increasingly detrimental effects on human health.Radiotherapy resistance diminishes treatment efficacy.Studies suggest that spermine synthas...
关键词：Spermine synthase Colorectal cancer RADIOSENSITIVITY AUTOPHAGY DNA damage 
Optimizing UVA and UVC synergy for effective control of harmful cyanobacterial blooms
《Environmental Science and Ecotechnology》2024年第6期215-225,共11页Yinjie Zhu Jian Ding Xiaoxiong Wang Xuejian Wang Huansheng Cao Fei Teng Shishi Yao Zhiru Lin Yuelu Jiang Yi Tao 
National Natural Science Foundation of China(52070117);Research Projects from Shenzhen Municipal Science and Technology Innovation Council(WDZC20200819163549002,JCYJ20200109142822787);Guangdong Higher Education Institutions Innovative Research Team of Urban Water Cycle and Ecological Safety,China(2023KCXTD053);Shenzhen Science and Technology Program,China(ZDSYS20220606100806014).
Harmful cyanobacterial blooms(HCBs)pose a global ecological threat.Ultraviolet C(UVC)irradiation at 254 nm is a promising method for controlling cyanobacterial proliferation,but the growth suppression is temporary.Res...
关键词：Cyanobacterial bloom Ultraviolet irradiation Photosynthetic damage DNA damage/repair Regulated cell death 
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