DNA_DAMAGE

作品数：397被引量：1149H指数：14
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Fat mass and obesity-associated protein in mesenchymal stem cells inhibits osteoclastogenesis via lnc NORAD/miR-4284 axis in ankylosing spondylitis
《World Journal of Stem Cells》2025年第3期28-43,共16页Wen-Jie Liu Jia-Xin Wang Quan-Feng Li Yun-Hui Zhang Peng-Fei Ji Jia-Hao Jin Yi-Bin Zhang Zi-Hao Yuan Pei Feng Yan-Feng Wu Hui-Yong Shen Peng Wang 
Supported by Guangdong Provincial Clinical Research Center for Orthopedic Diseases,No.2023B110001;the Excellent Medical Innovation Talent Program of the Eighth Affiliated Hospital of Sun Yat-sen University,No.YXYXCXRC202101;the National Natural Science Foundation of China,No.82172349,No.82372372,No.22105229,No.32170708,No.82102530,No.82102541,No.82103098,No.82103909,No.82104182,No.82104350,No.82170427,No.82171291,No.82172215,No.82172385,and No.82302661;Guangdong Natural Science Foundation,No.2023A1515010568 and No.2021A1515111057;Shenzhen Science and Technology Program,No.JCYJ20220530144201004 and No.RCBS20210609104445097;and Futian Healthcare Research Project,No.FTWS2022022,No.FTWS2021013,No.FTWS2023072,and No.FTWS2022047.
BACKGROUND Ankylosing spondylitis(AS)is recognized as a long-term inflammatory disorder that leads to inflammation in the spine and joints,alongside abnormal bone growth.In previous studies,we reported that mesenchyma...
关键词：Ankylosing spondylitis Mesenchymal stem cells OSTEOCLASTOGENESIS Fat mass and obesity-associated protein Non-coding RNA activated by DNA damage 
Material basis revelation of anti-hepatoma effect of Huachansu(Cinobufacini)through down-regulation of thymidylate synthase
《Chinese Herbal Medicines》2025年第1期127-138,共12页Qi Wu Qimei Chen Jingyi Yang Jiayu Zhang Ailin Yang 
financially supported by National Natural Science Foundation of China Grant(No.82204693);Taishan scholar engineering youth expert program of Shandong Province(No.tsqn202103110);Young and Creative Team for Talent Introduction of Shandong Province(No.10073004);Binzhou Medical University Scientific Research Fund for High-level Talents(NO.BY2020KYQD13,2019KYQD06);Standard study on Chinese medicinal materials and Decoction pieces in Shandong Province(No.2020-201)。
Objective:Hepatocellular carcinoma(HCC)is a leading cause of mortality worldwide.Huachansu(Cinobufacini)is active extract isolated from the dry skin of Bufo Bufo gargarizans.It has now been widely used in clinical tre...
关键词：DNA damage hepatocellular carcinoma Huachansu(Cinobufacini) material basis thymidylate synthase proteasomal degradation 
Cryopreservation of bovine sperm causes single‑strand DNA breaks that are localized in the toroidal regions of chromatin
《Journal of Animal Science and Biotechnology》2025年第1期92-106,共15页Jordi Ribas‑Maynou Rodrigo Muiño Carolina Tamargo Marc Yeste 
Ministry of Science,Innovation and Universities,Spain(NextGeneration EU funds;María Zambrano Program 124/MTAI/22;and PID2020-113320RB-I00);Agency for Management of University and Research Grants,Regional Government of Catalonia,Spain(2021-SGR-00900);Catalan Institution for Research and Advanced Studies(ICREA).
Background Sperm cryopreservation is widely used in the cattle industry,as it allows for disassociating the localiza-tion of sires and the collection of semen from the timing of artificial insemination.While freeze-th...
关键词：Cattle DNA damage Fertility Sperm Toroid linker regions 
Changes in the Mechanical Environment of the Nucleus with Cell Crowding and Its Effects on DNA Damage Resistance
《Journal of Biosciences and Medicines》2025年第1期230-242,共13页Kazuaki Nagayama Yuto Hirooka 
Nuclear DNA, which is essential for the transmission of genetic information, is constantly damaged by external stresses and is subsequently repaired by the removal of the damaged region, followed by resynthesis of the...
关键词：Cell Biomechanics MECHANOBIOLOGY Mechanical Properties DNA Damage γ-H2A.X 
Dietary administration of probiotic Bacillus coagulans and Mentha piperita can protect histological architecture and DNA damage in Catla catla(Hamilton,1822)
《Aquaculture and Fisheries》2024年第6期948-956,共9页Sonal Saluja Anita Bhatnagar 
sincerely thankful to HSCST-JRF(HSCST-2301)for fellowship.
The present experimental investigation was executed to evaluate the combined effect of probiotic bacterium Bacillus coagulans along with herb Mentha piperita on histological architecture;and extent of DNA damage after...
关键词：Bacillus COMET HEPATOCYTES HISTOLOGICAL MENTHA 
Enhancing the radiosensitivity of colorectal cancer cells by reducing spermine synthase through promoting autophagy and DNA damage
《World Journal of Gastrointestinal Oncology》2024年第12期4716-4727,共12页Yu-Bin Guo Yue-Ming Wu Zhi-Zhao Lin 
Supported by National Natural Science Foundation of China,No.82102996;Guangdong Provincial Natural Science Foundation,No.2022A1515010517;Guangzhou Science and Technology Plan Project,No.202201011016;President Foundation of Nanfang Hospital,Southern Medical University,No.2020C038.
BACKGROUND Colorectal cancer(CRC),the third most common cancer worldwide,has increasingly detrimental effects on human health.Radiotherapy resistance diminishes treatment efficacy.Studies suggest that spermine synthas...
关键词：Spermine synthase Colorectal cancer RADIOSENSITIVITY AUTOPHAGY DNA damage 
Optimizing UVA and UVC synergy for effective control of harmful cyanobacterial blooms
《Environmental Science and Ecotechnology》2024年第6期215-225,共11页Yinjie Zhu Jian Ding Xiaoxiong Wang Xuejian Wang Huansheng Cao Fei Teng Shishi Yao Zhiru Lin Yuelu Jiang Yi Tao 
National Natural Science Foundation of China(52070117);Research Projects from Shenzhen Municipal Science and Technology Innovation Council(WDZC20200819163549002,JCYJ20200109142822787);Guangdong Higher Education Institutions Innovative Research Team of Urban Water Cycle and Ecological Safety,China(2023KCXTD053);Shenzhen Science and Technology Program,China(ZDSYS20220606100806014).
Harmful cyanobacterial blooms(HCBs)pose a global ecological threat.Ultraviolet C(UVC)irradiation at 254 nm is a promising method for controlling cyanobacterial proliferation,but the growth suppression is temporary.Res...
关键词：Cyanobacterial bloom Ultraviolet irradiation Photosynthetic damage DNA damage/repair Regulated cell death 
Formation of reactive species via high power microwave induced DNA damage and promoted intrinsic pathway-mediated apoptosis in lung cancer cells:An in vitro investigation
《Fundamental Research》2024年第6期1542-1556,共15页Juie Nahushkumar Rana Sohail Mumtaz Ihn Han Eun Ha Choi 
supported by the National Research Foundation of Korea(NRF)with grants funded by the Korean government(MIST)(NRF-2022R1A2C1004257,NRF-2021R1A6A1A03038785);Kwangwoon University,Seoul,Korea,2023.
Lung cancer continues to be the second most common cancer diagnosed and the main cause of cancer-related death globally,which requires novel and effective treatment strategies.When considering treatment options,non-sm...
关键词：Non-small cell lung cancer High power microwave Microwave DNA damage Reactive species Mitochondria dysfunction Skin depth 
Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma
《Current Medical Science》2024年第5期890-901,共12页Bi-qiong ZHANG Feng-qing WANG Jie YIN Xiao-tan YU Zheng-xi HU Liang-hu GU Qing-yi TONG Yong-hui ZHANG 
financially supported by the National Natural Science Foundation of China(No.81903461);the Natural Science Foundation of Hubei Province(No.ZRMS2023000340).
Objective This study aimed to design and evaluate the efficacy of pyrrolidone derivatives as potential therapeutic agents against diffuse large B-cell lymphoma(DLBCL),a common and heterogeneous malignancy of the adult...
关键词：pyrrolidone analogs Michael acceptor DNA damage mitochondrial dysfunction APOPTOSIS 
8-Hydroxy-2'-Deoxyguanosine (8-OH-2dG) as a Biomarker of Oxidative Stress (OS) in the Acute Exacerbation of Spontaneous Preterm Birth (SPTB)
《Open Journal of Obstetrics and Gynecology》2024年第10期1548-1555,共8页Salma Abdi Mahmoud 
Spontaneous preterm birth (SPTB) is characterized by the delivery of a baby before 37 completed weeks of gestation, and this condition is associated with significant health challenges for the newborn. Emerging evidenc...
关键词：Preterm Birth 8-Hydroxy-2'-Deoxyguanosine Oxidative Stress DNA Damage 
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