supported by the National Natural Science Foundation of China grants 81872915(MWW),81573479(DHY),81773792(DHY),and 21704064(QTZ);The National Science&Technology Major Project"Key New Drug Creation and Manufacturing Program"(2018ZX09735-001 to MWW and 2018ZX09711002-002-005 to DHY);The National Key R&D Program of China grant 2018YFA0507000(MWW);Novo Nordisk-CAS Research Fund grant NNCAS-2017-1-CC(DHY).
SUMOylation is one of the posttranslational modifications that mediate cellular activities such as transcription,DNA repair,and signal transduction and is involved in the cell cycle.However,only a limited number of sm...