The current geometric and thermodynamic approaches in protein folding studies do not provide a definite solution to understanding mechanisms of folding of biological proteins. A major problem is that the protein is fi...
Ben-Naim warns that there are pitfalls in pursuing Anfinsen’s thermodynamic hypothesis. We show that the deepest one of his pitfalls is not a pitfall at all and the believing pursuing the minimum of the Gibbs free en...
Ben-Naim in three articles dismissed and “answered” the Levinthal’s paradox. He announces there are pitfalls caused by the “misinterpretation” of thermodynamic hypothesis. He claims no existence of Gibbs free ene...
This article is concerned with the so-called Levinthal’s paradox. It will be argued that many have sought a “solution” to Levinthal’s paradox, where in fact, the “solution” already appeared in Levinthal’s origi...
Three out of 125 “big questions of science”, can now be claimed to have been answered. All of these questions involve water;its structure, its role in protein folding and its role in protein-protein association.
In the beginning everything was explained in Biochemistry in terms of hydrogen-bonds (HB). Then, the devastating blow, known as the HB-inventory argument came;hydrogen bonding with water molecules compete with intramo...