GENE_SILENCING

作品数：162被引量：627H指数：11
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相关机构：中国科学院遗传与发育生物学研究所北京协和医学院中国农业科学院华中农业大学更多>>
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An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile被引量：2
《Nano Research》2021年第7期2247-2254,共8页Dinesh Dhumal Wenjun Lan Ling Ding Yifan Jiang Zhenbin Lyu Erik Laurini Domenico Marson Aura Tintaru Nelson Dusetti Suzanne Giorgio Juan Lucio Iovanna Sabrina Pricl Ling Peng 
This work was supported by the Ligue Nationale Contre le Cancer(L.P.,Z.L.);China Scholarship Council(W.L.,L.D.);Italian Association for Cancer Research(IG17413)(S.P.);the French National Research Agency under the frame of the H2020 Era-Net EURONANOMED European Research projects“Target4Cancer”,“NANOGLIO”,“TARBRAINFECT”,“NAN4-TUM”(L.P.),and H2020 NMBP“SAFE-N-MEDTECH”(L.P.);This article is based upon work from COST Action CA 17140“Cancer Nanomedicine from the Bench to the Bedside”supported by COST(European Cooperation in Science and Technology).
Gene therapy using small interfering RNA(siRNA)is emerging as a novel therapeutic approach to treat various diseases.However,safe and efficient siRNA delivery still constitutes the major obstacle for clinical implemen...
关键词：DENDRIMER SELF-ASSEMBLY ionizable vector siRNA delivery gene silencing non-viral vector 
Visualized and cascade-enhanced gene silencing by smart DNAzyme-graphene nanocomplex被引量：3
《Nano Research》2020年第8期2165-2174,共10页Lingjie Ren Xiaoxia Chen Chang Feng Lei Ding Xiaomin Liu Tianshu Chen Fan Zhang Yanli Li Zhongliang Ma Bo Tian Xiaoli Zhu 
This work was supported by the National Natural Science Foundation of China(No.21575088);the Natural Science Foundation of Shanghai(No.19ZR1474200).
BCL-2 gene as well as its products is recognized as a promising target for the molecular targeted therapy of tumors.However,due to certain defense measures of tumor cells,the therapeutic effect based on the gene silen...
关键词：BCL-2 gene gene silencing DNAZYME graphene oxide AS1411 
Design of synthetic materials for intracellular delivery of RNAs： From siRNA-mediated gene silencing to CRISPR/Cas gene editing
《Nano Research》2018年第10期5310-5337,共28页Jason B. Miller Daniel J. Siegwart 
Ribonucleic acids （RNAs） possess great therapeutic potential and can be used to treat a variety of diseases. The unique biophysical properties of RNAs, such as high molecular weight, negative charge, hydrophilicity,...
关键词：nucleic acid therapeutics nanoparticles synthetic nanomaterials RNA interference （RNAi） messenger RNA （mRNA） clustered regularly inter-spaced palindromic repeat（CRISPR）/Cas 
Highly efficient gene silencing and bioimaging based on fluorescent carbon dots in vitro and in vivo被引量：3
《Nano Research》2017年第2期503-519,共17页Seongchan Kim Yuri Choi Ginam Park Cheolhee Won Young-Joon Park Younghoon Lee Byeong-Su Kim DaI-Hee Min 
Small interfering RNA （siRNA） is an attractive therapeutic candidate for sequence- specific gene silencing to treat incurable diseases using small molecule drugs. However, its efficient intracellular delivery has re...
关键词：BIOIMAGING carbon dot gene delivery RNA interference targeted cancer therapy 
In vitro studies of polyethyleneimine coated miRNA microspheres as anticancer agents被引量：1
《Nano Research》2016年第6期1609-1617,共9页Irena Rytblat Ning Wu Huangli Xu Aharon Gedanken Xiukun Lin 
RNA plays important roles as a gene-silencing agent, a therapeutic agent for clinical treatment, and in the differentiation, proliferation, and development of cells. However, RNA is very difficult to work with due to ...
关键词：NANOSPHERES gene silencing gene delivery POLYETHYLENIMINE anticancer agents 
Aggregation-induced emission （ALE） dye loaded polymer nanoparticles for gene silencing in pancreatic cancer and their in vitro and in vivo biocompatibility evaluation被引量：4
《Nano Research》2015年第5期1563-1576,共14页Rui Hu Chengbin Yang Yucheng Wang Guimiao Lin Wei Qin Qingling Ouyang Wing-Cheung Law Quoc Toan Nguyen Ho Sup Yoon Xiaomei Wang Ken-Tye Yong Ben Zhong Tang 
This work was supported by the National Natural Science Foundation of China （NSFC） （61107017, 81301318）, the Start-up grant （M4080141.040） from Nanyang Technological University, Tier 1 Academic Research Funds （M4010360.040 RG29/10） from Singapore Ministry of Education and partially from the Singapore Ministry of Education under a Tier 2 Research Grant MOE2010-T2-2-010 （4020020.040 ARC2/11） and the grant from the Shenzhen Basic Research Project （JC201005280391A）
We have developed aggregation-induced emission （AIE） dye loaded polymer nanoparticles with deep-red emission for siRNA delivery to pancreatic cancer cells. Two US Food and Drug Administration （FDA） approved surfac...
关键词：aggregation-induced emission polymer nanoparticles gene silencing pancreatic cancer 
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