GENE_SILENCING

作品数：162被引量：627H指数：11
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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease
《Neural Regeneration Research》2025年第9期2538-2555,共18页Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren 
supported by Open Project of the Key Laboratory of Trauma and Orthopedics Research Medicine in Henan Province,No.HZKFKT20220504(to YZ);the National Natural Science Foundation of China,No.32000877(to YZ);and Open Scientific Research Program of Military Logistics,No.BLB20J009(to YZ)。
Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive defi...
关键词：blood-brain barrier cognitive dysfunction EXOSOMES gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles NEUROINFLAMMATION polymer nanoparticles stem cells 
A small RNA effector conserved in herbivore insects suppresses host plant defense by cross-kingdom gene silencing
《Molecular Plant》2025年第3期437-456,共20页Wen-Hao Han Shun-Xia Ji Feng-Bin Zhang Hong-Da Song Jun-Xia Wang Xiao-Ping Fan Rui Xie Shu-Sheng Liu Xiao-Wei Wang 
supported by National Natural Science Foundation of China(31925033,32161143008);National Key Research and Development Program(2021YFC2600100).
Herbivore insects deploy salivary effectors to manipulate the defense of their host plants.However,it remains unclear whether small RNAs from insects can function as effectors in regulating plant-insect interactions.H...
关键词：cross-kingdom regulation plant-insect interaction salivary effector small RNA insect exosomes 
Spray-induced gene silencing to control plant pathogenic fungi:A step-by-step guide
《Journal of Integrative Plant Biology》2025年第3期801-825,共25页Sandra Mosquera Mireille Ginésy Irene Teresa Bocos-Asenjo Huma Amin Sergio Diez-Hermano Julio Javier Diez Jonatan Niño-Sánchez 
funded by the Spanish Ministry of Science,Innovation and Universities(Project No.PID2023-148417OAI00);the Spanish Ministry of Science and Innovation and by the European Union through the Next Generation Funds(Project No.PLEC2021-008076);funded by the Junta de Castilla y León through the projects“VAP208P20”,“VA178P23”;the program“CLU-2019-01 and CL-EI-2021-05-iuFOR Unit of Excellence”;co-funded by the European Regional Development Fund;support from the European Union's Horizon Europe research and innovation programme under the MSCA agreement No.101068728;PhD fellowships funded by Junta de Castilla y León(Orden EDU/601/2020 and Orden EDU/1508/2020);a Juan de la Cierva postdoctoral fellowship funded by MCIU/AEI/10.13039/501100011033 and“NextGenerationEU”/PRTR(Spain)。
RNA interference(RNAi)-based control technologies are gaining popularity as potential alternatives to synthetic fungicides in the ongoing effort to manage plant pathogenic fungi.Among these methods,spray-induced gene ...
关键词：dsRNA delivery dsRNA stability dsRNA uptake fungal plant pathogens NANOCARRIERS spray-induced gene silencing 
Systemically intravenous siRNA delivery into brain with a targeting and efficient polypeptide carrier and its evaluation on anti-glioma efficacy
《Chinese Chemical Letters》2025年第3期396-401,共6页Liqing Chen Zheming Zhang Yanhong Liu Chenfei Liu Congcong Xiao Liming Gong Mingji Jin Zhonggao Gao Wei Huang 
supported by CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-026,China).
Gliomas are the most common intracranial tumors with poor survival and high mortality.Furthermore,the clinical efficacy of current drugs is still not ideal;despite the development of several therapeutic drugs over the...
关键词：15-Amino-acid peptide GLIOMA Brain targeting Gene silencing Transvascular delivery 
Puccinia triticina effector Pt-1234 modulates wheat immunity by targeting transcription factor TaNAC069 via its C subdomain被引量：1
《The Crop Journal》2025年第1期69-78,共10页Huaimin Geng Yanjun Zhang Zhen Qin Shen Wang Changshan Liu Zhongchi Cui Daqun Liu Haiyan Wang 
funded by State Key Laboratory of North China Crop Improvement and Regulation(NCCIR2023ZZ-10);the National Natural Science Foundation of China(32172384 and 31501623);the Natural Science Foundation of Hebei(C2020204028);the Science and Technology Research Project of Higher Education of Hebei(ZC2023178).
The NAC(NAM,ATAF1/2,and CUC2)is a defense-associated transcription factor(TF)family that positively regulates defense responses to pathogen infection.TaNAC069 positively regulates resistance in wheat to Puccinia triti...
关键词：EFFECTORS NAC transcription factor Host-induced gene silencing Puccinia triticina Triticum aestivum 
Advances and prospects of RNA delivery nanoplatforms for cancer therapy
《Acta Pharmaceutica Sinica B》2025年第1期52-96,共45页Mohamed S.Attia Gregor Kijanka Nam-Trung Nguyen Jun Zhang Hongjie An 
support from the Australian Research Council Future Fellowship(No.FT180100361,Australia);Discovery Project(No.DP230100556,Australia);support from Australian Laureate Fellowship(FL230100023,Australia).
Modern oncology is rapidly evolving,driven by recent advances in RNA-based therapeutics.As new emerging cutting-edge technology,mRNA vaccines hold excellent promise for encoding immunostimulatory molecules,tumor-assoc...
关键词：Cancer therapy mRNA vaccine RNAINTERFERENCE Nanoplatforms Gene delivery IMMUNOTHERAPIES Gene silencing Neoantigens 
Iron and siRNA co-encapsulated ferritin nanocages induce ferroptosis synergistically for cancer therapy
《Acta Pharmaceutica Sinica B》2025年第1期526-541,共16页Danni Liu Yaoqi Wang Qi Sun Dong Mei Xiaoling Wang Yan Su Jie Zhang Ran Huo Yang Tian Siyu Liu Shuang Zhang Chunying Cui 
supported by the National Natural Science Foundation of China(81502688);Cooperation Research Funding of Capital Medical University(2020KJ000514,China);Cooperation Research Funding of Capital Medical University(2023KJ000814,China);R&D Program of Beijing Municipal Education Commission(KM202210025024,China).
Ferroptosis has received great attention as an iron-dependent programmed cell death for efficient cancer therapy.However,with the accumulation of iron in tumor cells,the antioxidant system is activated by reducing glu...
关键词：Ferroptosis FERRITIN Iron homeostasis SIRNA Gene silencing Glutathione peroxidase 4 ANTITUMOR Lipid peroxidation 
Spray-induced gene silencing in phytopathogen:Mechanisms,applications,and progress
《Advanced Agrochem》2024年第4期289-297,共9页Li He Yifan Zhou Qin Mo Yanna Huang Xueming Tang 
supported by the National Key Research and Development Program of China(2023YFD1700700);Shanghai Agricultural Science and Technology Innovation Project(K2023018);the Shanghai Jiaotong University Talent Foundation(No.WH221615001),and Program for Shanghai Leading Talent.
Phytopathogens can continuously cause serious losses worldwide to crop,fruit,and vegetable yields.The excessive use of conventional fungicides in pathogen management has raised severe environmental and health side eff...
关键词：PATHOGEN SIGS dsRNA uptake dsRNA stability Nanoparticles dsRNA production Risk assessment Regulatory framework 
Profiling of Phakopsora pachyrhizi transcriptome revealed co-expressed virulence effectors as prospective RNA interference targets for soybean rust management
《Journal of Integrative Plant Biology》2024年第11期2543-2560,共18页Haibing Ouyang Guangzheng Sun Kainan Li Rui Wang Xiaoyu Lv Zhichao Zhang Rong Zhao Ying Wang Haidong Shu Haibin Jiang Sicong Zhang Jinbin Wu Qi Zhang Xi Chen Tengfei Liu Wenwu Ye Yan Wang Yuanchao Wang 
supported by grants from the National Key Research and Development Program of China(2022YFF1001500);the Fundamental Research Funds for the Central Universities(CGPY2024001);the Zhongshan Biological Breeding Laboratory(ZSBBL-KY2023-03)。
Soybean rust(SBR),caused by an obligate biotrophic pathogen Phakopsora pachyrhizi,is a devastating disease of soybean worldwide.However,the mechanisms underlying plant invasion by P.pachyrhizi are poorly understood,wh...
关键词：RNAi soybean rust spray-induced gene silencing(SIGS) TRANSCRIPTOMES virulence effector 
Host-induced gene silencing of the Verticillium dahliae thiamine transporter protein gene(VdThit)confers resistance to Verticillium wilt in cotton被引量：1
《Journal of Integrative Agriculture》2024年第10期3358-3369,共12页Qi Wang Guoqiang Pan Xingfen Wang Zhengwen Sun Huiming Guo Xiaofeng Su Hongmei Cheng 
supported by the National Key Research and Development Program of China(2022YFD1200300);the National Natural Science Foundation of China(32072376 and 32372515);Winall Hi-tech Seed Co.,Ltd.,China(GMLM2023);the Nanfan Special Project of Chinese Academy of Agricultural Sciences(CAAS)(ZDXM2303 and YBXM2415);the Natural Science Foundation of Hebei Province,China(C2022204205);the Agricultural Science and Technology Innovation Program of CAAS。
Verticillium wilt(VW),induced by the soil-borne fungus Verticillium dahliae(Vd),poses a substantial threat to a diverse array of plant species.Employing molecular breeding technology for the development of cotton vari...
关键词：Verticillium dahliae thiamine transporter host-induced gene silencing(HIGS) RNAi 
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