GENE_SILENCING

作品数：157被引量：622H指数：11
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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease
《Neural Regeneration Research》2025年第9期2538-2555,共18页Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren 
supported by Open Project of the Key Laboratory of Trauma and Orthopedics Research Medicine in Henan Province,No.HZKFKT20220504(to YZ);the National Natural Science Foundation of China,No.32000877(to YZ);and Open Scientific Research Program of Military Logistics,No.BLB20J009(to YZ)。
Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive defi...
关键词：blood-brain barrier cognitive dysfunction EXOSOMES gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles NEUROINFLAMMATION polymer nanoparticles stem cells 
Puccinia triticina effector Pt-1234 modulates wheat immunity by targeting transcription factor TaNAC069 via its C subdomain被引量：1
《The Crop Journal》2025年第1期69-78,共10页Huaimin Geng Yanjun Zhang Zhen Qin Shen Wang Changshan Liu Zhongchi Cui Daqun Liu Haiyan Wang 
funded by State Key Laboratory of North China Crop Improvement and Regulation(NCCIR2023ZZ-10);the National Natural Science Foundation of China(32172384 and 31501623);the Natural Science Foundation of Hebei(C2020204028);the Science and Technology Research Project of Higher Education of Hebei(ZC2023178).
The NAC(NAM,ATAF1/2,and CUC2)is a defense-associated transcription factor(TF)family that positively regulates defense responses to pathogen infection.TaNAC069 positively regulates resistance in wheat to Puccinia triti...
关键词：EFFECTORS NAC transcription factor Host-induced gene silencing Puccinia triticina Triticum aestivum 
Spray-induced gene silencing in phytopathogen:Mechanisms,applications,and progress
《Advanced Agrochem》2024年第4期289-297,共9页Li He Yifan Zhou Qin Mo Yanna Huang Xueming Tang 
supported by the National Key Research and Development Program of China(2023YFD1700700);Shanghai Agricultural Science and Technology Innovation Project(K2023018);the Shanghai Jiaotong University Talent Foundation(No.WH221615001),and Program for Shanghai Leading Talent.
Phytopathogens can continuously cause serious losses worldwide to crop,fruit,and vegetable yields.The excessive use of conventional fungicides in pathogen management has raised severe environmental and health side eff...
关键词：PATHOGEN SIGS dsRNA uptake dsRNA stability Nanoparticles dsRNA production Risk assessment Regulatory framework 
Profiling of Phakopsora pachyrhizi transcriptome revealed co-expressed virulence effectors as prospective RNA interference targets for soybean rust management
《Journal of Integrative Plant Biology》2024年第11期2543-2560,共18页Haibing Ouyang Guangzheng Sun Kainan Li Rui Wang Xiaoyu Lv Zhichao Zhang Rong Zhao Ying Wang Haidong Shu Haibin Jiang Sicong Zhang Jinbin Wu Qi Zhang Xi Chen Tengfei Liu Wenwu Ye Yan Wang Yuanchao Wang 
supported by grants from the National Key Research and Development Program of China(2022YFF1001500);the Fundamental Research Funds for the Central Universities(CGPY2024001);the Zhongshan Biological Breeding Laboratory(ZSBBL-KY2023-03)。
Soybean rust(SBR),caused by an obligate biotrophic pathogen Phakopsora pachyrhizi,is a devastating disease of soybean worldwide.However,the mechanisms underlying plant invasion by P.pachyrhizi are poorly understood,wh...
关键词：RNAi soybean rust spray-induced gene silencing(SIGS) TRANSCRIPTOMES virulence effector 
Host-induced gene silencing of the Verticillium dahliae thiamine transporter protein gene(VdThit)confers resistance to Verticillium wilt in cotton被引量：1
《Journal of Integrative Agriculture》2024年第10期3358-3369,共12页Qi Wang Guoqiang Pan Xingfen Wang Zhengwen Sun Huiming Guo Xiaofeng Su Hongmei Cheng 
supported by the National Key Research and Development Program of China(2022YFD1200300);the National Natural Science Foundation of China(32072376 and 32372515);Winall Hi-tech Seed Co.,Ltd.,China(GMLM2023);the Nanfan Special Project of Chinese Academy of Agricultural Sciences(CAAS)(ZDXM2303 and YBXM2415);the Natural Science Foundation of Hebei Province,China(C2022204205);the Agricultural Science and Technology Innovation Program of CAAS。
Verticillium wilt(VW),induced by the soil-borne fungus Verticillium dahliae(Vd),poses a substantial threat to a diverse array of plant species.Employing molecular breeding technology for the development of cotton vari...
关键词：Verticillium dahliae thiamine transporter host-induced gene silencing(HIGS) RNAi 
GmDFB1,an ARM-repeat superfamily protein,regulates floral organ identity through repressing siRNA-and miRNA-mediated gene silencing in soybean
《Journal of Integrative Plant Biology》2024年第8期1620-1638,共19页Jie Li Wenxiao Zhang Qing Lu Jiaqi Sun Chuang Cheng Shiyu Huang Shuo Li Qiang Li Wei Zhang Chuanen Zhou Bin Liu Fengning Xiang 
supported by the National Key Research and Development Program of China(Grant Nos.2021YFF1001201 and 2022YFF1001601-4);Key Research and Development Program of Shandong Province(Grant Nos.2023LZGC008 and 2021LZGC003);the National Scientific and Technological Innovation 2030-Major Project(Grant No.2023ZD040360102);the Joint Funds of the National Natural Science Foundation of China(Grant No.U1906203);the National Transgenic Project of China(Grant Nos.2016ZX08010002-009 and 2018ZX08009-14B);Taishan Scholar Youth Project of Shandong Province(Grant No.tsqn202306072);Young Scientists Fund of the National Natural Science Foundation of China(Grant No.32301876);Natural Science Foundation of Shandong Province Youth Fund(Grant No.ZR2023QC180);Qingdao Natural Science Foundation(Grant No.23-2-1-38-zyyd-jch);Shandong University Qilu Young Scholar。
The development of flowers in soybean(Glycine max)is essential for determining the yield potential of the plant.Gene silencing pathways are involved in modulating flower development,but their full elucidation is still...
关键词：ARM-repeat superfamily protein ARGONAUTE 1 SUPER KILLER 7 flower development gene silencing small RNAs SOYBEAN 
Host-Induced Gene Silencing of Effector AGLIP1 Enhanced Resistance of Rice to Rhizoctonia solani AG1-IA被引量：1
《Rice science》2024年第4期463-474,I0031-I0034,共16页ZHAO Mei LIU Xiaoxue WAN Jun ZHOU Erxun SHU Canwei 
supported by the Henan Province Science and Technology Research Project, China (Grant No. 242102110232);the National Natural Science Foundation of China (Grant No. 31801677);the Major Program of Guangdong Basic and Applied Basic Research, China (Grant No. 2019B030302006)。
Rice sheath blight, caused by Rhizoctonia solani AG1-IA, is a major disease in rice-growing areas worldwide. Effectors of phytopathogenic fungi play important roles during the infection process of fungal pathogens ont...
关键词：Rhizoctonia solani host-induced gene silencing LIPASE tobacco rattle virus 
Nanomedicine integrating the lipidic derivative of 5-fluorouracil,miriplatin and PD-L1 si RNA for enhancing tumor therapy
《Chinese Chemical Letters》2024年第6期385-391,共7页An Lu Yuhao Guo Yi Yan Lin Zhai Xiangyu Wang Weiran Cao Zijie Li Zhixia Zhao Yujie Shi Yuanjun Zhu Xiaoyan Liu Huining He Zhiyu Wang Jian-Cheng Wang 
financial support from the Basic Research Cooperation Project of Beijing,Tianjin,Hebei from the Natural Science Foundation of Beijing(No.J200018),Tianjin(No.20JCZXJC00070),and Hebei(No.H2020206649);Beijing Natural Science Foundation(No.7214281);the projects of National Natural Science Foundation of China(No.81973259)。
Immunosuppressive microenvironments present critical problems in clinical chemotherapy.To regulate the tumor immune microenvironment for enhancing antitumor effect,a combination of immune checkpoint inhibitors(ICIs)wi...
关键词：CHEMO-IMMUNOTHERAPY Immune checkpoint inhibition Gene silencing MIRIPLATIN Macrophage phagocytosis Nanotechnology 
Microbe-induced gene silencing explores interspecies RNAi and opens up possibilities of crop protection被引量：1
《Science China(Life Sciences)》2024年第3期626-628,共3页Rongxiang Fang 
In most eukaryotes, small RNA(sRNA)-mediated RNA silencing(or RNA interference, RNAi) is an evolutionarily conserved mechanism that regulates gene expression in a sequence-specific manner.Generally, s RNAs are produce...
关键词：protection CONSERVED MANNER 
Elaborately engineering of lipid nanoparticle for targeting delivery of siRNA and suppressing acute liver injury
《Chinese Chemical Letters》2024年第2期323-328,共6页Qiu Wang Qikun Jiang Dan Li Zimeng Yang Lin Gao Fan Liu Chang Li Yao Feng Zhonggui He Cong Luo Jin Sun 
financially supported by the National Key R&D Program of China(No.2021YFA0909900).
Small interfering RNA(siRNA)-based gene silencing has been considered as a potential therapy modality against inflammatory diseases.Nevertheless,the effective delivery of siRNA to desired destination still remains cha...
关键词：Lipid nanoparticle Targeting siRNA delivery Acute liver injury Gene silencing Tumor necrosis factorα 
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