TRANSCRIPTOMES

作品数：56被引量：116H指数：7
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Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancer
《Chinese Journal of Cancer Research》2025年第1期90-114,共25页Tao Ding Lina He Guowen Lin Lei Xu Yanjun Zhu Xinan Wang Xuefei Liu Jianming Guo Fanghong Lei Zhixiang Zuo Jianghua Zheng 
supported by Shanghai Science and Technology Commission,China(No.21S11902100);Shanghai Municipal Health Commission Scientific Research Project(No.202140308);Clinical Research Project of Tongji Hospital of Tongji University[No.ITJ(ZD)2209];Shanghai Tongji Hospital National Natural Science Foundation Cultivation Project(No.GJPY2216);Shanghai Medical Innovation Research Special Foundation(No.23Y11908800);CSCO-Haosen Oncology Research Fund(No.Y-HS202301-0096).
Objective:Prostate cancer(PCa)is a complex disease characterized by diverse cellular ecosystems within the tumor microenvironment(TME)and high tumor heterogeneity,which challenges clinically stratified management and ...
关键词：Single-cell RNA sequencing prostate cancer lineage plasticity tumor heterogeneity molecular classification 
Genomic insights into ecological adaptation of oaks revealed byphylogenomic analysis of multiple species
《Plant Diversity》2025年第1期53-67,共15页Tian-Rui Wang Xin Ning Si-Si Zheng Yu Li Zi-Jia Lu Hong-Hu Meng Bin-Jie Ge Gregor Kozlowski Meng-Xiao Yan Yi-Gang Song 
supported by the National Natural Science Foundation of China(No.31901217);the Special Fund for Scientific Research of Shanghai Landscaping and City Appearance Administrative Bureau(grant numbers G192422,G242414,and G242416).
Understanding the ecological adaptation of tree species can not only reveal the evolutionary potential but also benefit biodiversity conservation under global climate change.Quercus is a keystone genus in Northern Hem...
关键词：QUERCUS Ecological adaptation PHYLOGENOMICS TRANSCRIPTOMES FAGACEAE 
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC
《International Journal of Oral Science》2024年第4期711-727,共17页Lixuan Wang Rongchun Yang Yue Kong Jing Zhou Yingyao Chen Rui Li Chuwen Chen Xinran Tang Xiaobing Chen Juan Xia Xijuan Chen Bin Cheng Xianyue Ren 
supported by grants from the GuangDong Basic and Applied Basic Research Foundation(No.2023A1515030121,No.2021A1515111020,No.2023A1515010246);the National Natural Science Foundation of China(No.82273148,No.82103555,No.82301086);the Science and Technology Projects in Guangzhou(No.202206080009)。
Metabolic heterogeneity plays a central role in sustaining uncontrolled cancer cell proliferation and shaping the tumor microenvironment(TME),which significantly compromises the clinical outcomes and responses to ther...
关键词：metabolism therapeutic precise 
Maize multi-omics reveal leaf water status controlling of differential transcriptomes,proteomes and hormones as mechanisms of age-dependent osmotic stress response in leaves
《Stress Biology》2024年第1期525-542,共18页Liangjie Niu Wenkang Wang Yingxue Li Xiaolin Wu Wei Wang 
supported by the National Natural Science Foundation of China(32272026 and U1904107 to W.W.);the National Key Laboratory of Wheat and Maize Crop Science,Henan agricultural University,China(39990101 to W.W.).
Drought-induced osmotic stress severely affects the growth and yield of maize.However,the mechanisms underlying the different responses of young and old maize leaves to osmotic stress remain unclear.To gain a systemat...
关键词：Age-related changes Old and young leaves Osmotic stress PHYTOHORMONE Proteome Transcriptome Zea mays 
Stomatal maturomics:hunting genes regulating guard cell maturation and function formation from single-cell transcriptomes
《Journal of Genetics and Genomics》2024年第11期1286-1299,共14页Yuming Peng Yi Liu Yifan Wang Zhenxing Geng Yue Qin Shisong Ma 
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Science(XDA24010303);the National Natural Science Foundation of China(31770268);the Fundamental Research Funds for the Central Universities(WK2070000091);the University of Science and Technology of China(Start-up fund to S.M.)。
Stomata play critical roles in gas exchange and immunity to pathogens.While many genes regulating early stomatal development up to the production of young guard cells(GCs)have been identified in Arabidopsis,much less ...
关键词：Stomata maturomics Hoop rigidity Stomatal aperture Single-cell analysis G2-like transcription factors MYS1 MYS2 
Profiling of Phakopsora pachyrhizi transcriptome revealed co-expressed virulence effectors as prospective RNA interference targets for soybean rust management
《Journal of Integrative Plant Biology》2024年第11期2543-2560,共18页Haibing Ouyang Guangzheng Sun Kainan Li Rui Wang Xiaoyu Lv Zhichao Zhang Rong Zhao Ying Wang Haidong Shu Haibin Jiang Sicong Zhang Jinbin Wu Qi Zhang Xi Chen Tengfei Liu Wenwu Ye Yan Wang Yuanchao Wang 
supported by grants from the National Key Research and Development Program of China(2022YFF1001500);the Fundamental Research Funds for the Central Universities(CGPY2024001);the Zhongshan Biological Breeding Laboratory(ZSBBL-KY2023-03)。
Soybean rust(SBR),caused by an obligate biotrophic pathogen Phakopsora pachyrhizi,is a devastating disease of soybean worldwide.However,the mechanisms underlying plant invasion by P.pachyrhizi are poorly understood,wh...
关键词：RNAi soybean rust spray-induced gene silencing(SIGS) TRANSCRIPTOMES virulence effector 
The advantages of multi-level omics research on stem cell-based therapies for ischemic stroke
《Neural Regeneration Research》2024年第9期1998-2003,共6页Yiqing Wang Chuheng Chang Renzhi Wang Xiaoguang Li Xinjie Bao 
supported by the National Key Research and Development Program of China,No.2018YFA0108602;the CAMS Initiative for Innovative Medicine,No.2021-1-I2M-019;the National High Level Hospital Clinical Research Funding,No.2022-PUMCH-C-042(all to XB).
Stem cell transplantation is a potential therapeutic strategy for ischemic stroke. However, despite many years of preclinical research, the application of stem cells is still limited to the clinical trial stage. Altho...
关键词：ischemic stroke mesenchymal stem cells metabolomics multilevel omics neural stem/progenitor cells NEUROINFLAMMATION PATHOPHYSIOLOGY proteomics stem cell therapy TRANSCRIPTOMES 
Single-cell transcriptomes provide insights into expansion of glial cells in Bombyx mori
《Insect Science》2024年第4期1041-1054,共14页Xiaojing Liu Zhongjie Zhang Bo Hu Kai Chen Ye Yu Hui Xiang Anjiang Tan 
supported by the National Science Foundation of China(32000339,32000336 and 31925007);the Natural Science Foundation of Jiangsu Province(BK20231249,BK20221292 and BK20210880)。
The diversity of cell types in the brain and how these change during different developmental stages,remains largely unknown.The life cycle of insects is short and goes through 4 distinct stages including embryonic,lar...
关键词：brain NEUROPEPTIDE SILKWORM single-cell transcriptome 
Progressive meristem and single-cell transcriptomes reveal the regulatory mechanisms underlying maize inflorescence development and sex differentiation
《Molecular Plant》2024年第7期1019-1037,共19页Yonghao Sun Liang Dong Lu Kang Wanshun Zhong David Jackson Fang Yang 
the National Natural Science Foundation of China(32172026,U22A20460 to F.Y.);the Interdisciplinary Sciences Research Institute(2662021JC005 to F.Y.);111 Project Crop genomics and Molecular Breeding(B20051 to F.Y.).
Maize develops separate ear and tassel inflorescences with initially similar morphology but ultimately different architecture and sexuality.The detailed regulatory mechanisms underlying these changes still remain larg...
关键词：MAIZE INFLORESCENCE floral organ sex differentiation single-cell RNA sequencing RNA-binding protein 
High-throughput RNA sequencing reveals differences between the transcriptomes of the five spore forms of Puccinia striiformis f.sp.tritici,the wheat stripe rust pathogen被引量：1
《Stress Biology》2023年第1期317-331,共15页Gangming Zhan Jia Guo Yuan Tian Fan Ji Xingxuan Bai Jing Zhao Jun Guo Zhensheng Kang 
financially supported by the National Key Research and Development Program of China(2021YFD1401000);the National Natural Science Foundation of China(32172380 and 32102175);the 111 Project of the Ministry of Education of China(B0719026);the Open Project Program of State Key Laboratory of Crop Stress Biology for Arid Areas(CSBAAKF2021013).
The devastating wheat stripe(yellow)rust pathogen,Puccinia striiformis f.sp.tritici(Pst),is a macrocyclic and heteroe-cious fungus.Pst produces urediniospores and teliospores on its primary host,wheat,and pycniospores...
关键词：Puccinia striiformis f.sp.tritici Transcriptome Gene expression Rust life cycle Spore stages 
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