GENE_TRANSFECTION

作品数：116被引量：264H指数：9
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Modulating the Oxidation Degree of Linear Polyethyleneimine for Preparation of Highly Efficient and Low-cytotoxicity Degradable Gene Delivery Carriers
《Chinese Journal of Polymer Science》2024年第11期1699-1709,I0008,共12页Xiao-Ya Guo Zhi-Yu Yang Hua-Pan Fang Dan-Hua Zhou Xuan Pang Hua-Yu Tian Xue-Si Chen 
financially supported by National Key Research and Development Program of China(No.2021YFB3800900);the National Natural Science Foundation of China(Nos.51925305,51833010 and 52203183);Natural Science Foundation of Xiamen,China(No.3502Z202371004);Fundamental Research Funds for the Central Universities(No.20720230004);the talent cultivation project Funds for the Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(No.HRTP-[2022]52)。
Polyethyleneimine(PEI),as a widely used polymer material in the field of gene delivery,has been extensively studied for modification and shielding to reduce its cytotoxicity.However,research aimed at preparing degrada...
关键词：POLYETHYLENEIMINE Gene delivery Gene transfection Degradable gene carriers 
Efficient gene transfection of suspension cells by highly branched poly(β-amino ester)
《Chinese Chemical Letters》2023年第7期176-181,共6页Delu Che Chenfei Wang Zhili Li Kaixuan Wang Shuaiwei Sun Xinyue Zhang Yi Li Zhengju Chen Lei Guo Yajing Hou Dezhong Zhou Songmei Geng 
funded by National Natural Science Foundation of China (NSFC, No. 51903202);the Innovation Capability Support Program of Shaanxi (No. 2022TD-48);the Key R&D Program of Shaanxi Province (No. 2020GXLH-Y-016)。
Suspension cells play a crucial role in many biological processes. However, compared to adherent cells, it is particularly challenging to introduce exogenous genes into suspension cells to regulate their biological fu...
关键词：Non-viral vector Highly branched poly(β-amino ester) Gene transfection High transfection efficiency Suspension cells Mast cells 
Pillar[5]arene-modified peptide-guanidiniocarbonylpyrrol amphiphiles with gene transfection properties
《Chinese Chemical Letters》2023年第5期246-249,共4页Kaiya Wang Minzan Zuo Tao Zhang Huilan Yue Xiao-Yu Hu 
supported by the Natural Science Foundation of Jiangsu Province(Nos.BK20200432,BK20211179);National Natural Science Foundation of China(Nos.22271154,M-0411);the Fundamental Research Funds for the Central Universities(Nos.NG2022003,NS2021040)。
Pillar[5]arene-modified amphiphilic peptides with varying numbers of guanidiniocarbonylpyrrol(GCP)moieties have been successfully synthesized,which can self-assemble to multivalent cationic superstructures in aqueous ...
关键词：arene Guanidinocarbonylpyrrole Gene transfection Amphiphiles Structure-activity relationship 
Highly branched poly(β-amino ester)s with narrow molecular weight distribution: Fractionation and gene transfection activity
《Chinese Chemical Letters》2023年第3期383-387,共5页Chenfei Wang Litao Sun Qiuxia Li Zhili Li Chengyuan Xu Xinyue Zhang Jianjun Shi Hao Zhou Wenxin Wang Dezhong Zhou 
funded by the National Natural Science Foundation of China(NSFC,No.51903202);Hainan Provincial Natural Science Foundation of China(No.521RC1058);the Key R&D Program of Shaanxi Province(No.2020GXLH-Y-016);the Natural Science Foundation of Shaanxi Province(No.2020JM-055);the Fundamental Research Funds for the Central Universities(No.xtr042019020);the Young Talents Support Plan of Xi’an Jiaotong University(No.HG6J002)。
Highly branched poly(β-amino ester)s(HPAEs) have shown their great promise in gene delivery. However, their broad molecular weight distribution(MWD) poses an additional challenge to the mechanistic understanding of t...
关键词：Gene transfection Non-viral vector Highly branched poly(β-amino ester)s FRACTIONATION Transfection activity 
Dopamine-mimetic-coated polyamidoamine-functionalized Fe_(3)O_(4) nanoparticles for safe and efficient gene delivery
《Frontiers of Materials Science》2023年第1期141-152,共12页Liang Liu Chaobing Liu Zhaojun Yang Yiran Chen Xin Chen Jintao Guan 
This work was supported in part by the National Natural Science Foundation of China(Grant No.21602166);the Natural Science Foundation of Hubei Province(Grant No.2020CFB760);the Research and Innovation Initiatives of WHPU(Grant No.2021Y11).
Fe_(3)O_(4) nanoparticles(NPs)are widely used in the construction of drug and gene delivery vectors because of their particular physicochemical properties.Surface modification can not only reduce the cytotoxicity of F...
关键词：gene vector nanoparticle POLYDOPAMINE gene transfection 
Ultrasound-targeted cationic microbubble-mediated gene transfection and inhibition of retinal neovascularization被引量：2
《International Journal of Ophthalmology(English edition)》2022年第6期876-885,共10页Ming-Xing Wu Yu Zhou Xi-Yuan Zhou Yan Xu 
Supported by the National Natural Science Foundation for Youth of China(No.81901765)。
AIM:To investigate whether ultrasound-targeted cationic microbubbles(CMBs)destruction could deliver endostatingreen fluorescent protein(GFP)plasmids efficiently to the human retinal endothelial cells(HRECs)and inhibit...
关键词：ULTRASOUND cationic microbubbles human retinal vascular endothelial cells gene transfection retinal neovascularization 
Protein nanocapsules based vectors for efficient gene transfection
《Nano Research》2022年第1期264-271,共8页Xuan Hu Song Wang Junjie Xu Yilong Yang Zhang Zhang Xiaolin Wang Xiaopeng Zhang Wei Chen 
supported by the National Science and Technology Major Project(Nos.2018ZX09J18101 and 2019ZX09J19103);the National Natural Science Foundation of China(No.81703048).
Gene therapy employs exogenous nucleic acids to treat genetic diseases and disorders.The insufficient cytosolic delivery of genetic materials remains a major hurdle for effective gene therapy.To address this challenge...
关键词：protein nanocapsule self-assembly gene transfection cytosolic delivery degradation 
Effects of Branching Strategy on the Gene Transfection of Highly Branched Poly(β-amino ester)s被引量：2
《Chinese Journal of Polymer Science》2020年第8期830-839,I0006,共11页Yao Wang Chen-Fei Wang Ming Li De-Zhong Zhou Wei Huang Wen-Xin Wang 
This work was financially supported by Science Foundation Ireland(SFI)Principal Investigator Program(No.13/IA/1962);the National Natural Science Foundation of China(Nos.51873179,51903202),and University College Dublin。
Highly branched poiy(β-amino ester)s(HPAEs)have emerged as one type of the most viable non-viral gene delivery vectors,both in vitro and in viva.However,the effects of different branching strategies on the gene trans...
关键词：Gene therapy Non-viral gene vector Highly branched polymer Branching strategy 
Use of cationic microbubbles targeted to P-selectin to improve ultrasound-mediated gene transfection of hVEGF_(165) to the ischemic myocardium被引量：4
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2018年第9期699-707,共9页Wei-hui SHENTU Cao-xin YAN Chun-mei LIU Rui-xiang QI Yao WANG Zhao-xu HUANG Li-ming ZHOU Xiang-dong YOU 
Project supported by the Natural Science Foundation of Zhejiang Province(No.LY14H180003);the National Natural Science Foundation of China(No.81301231);the General Research Project of Zhejiang Provincial Department of Education(No.Y201636244),China
Gene therapies have been applied to the treatment of cardiovascular disease, but their use is limited by the need to deliver them to the right target. We have employed targeted contrast ultrasound-mediated gene transf...
关键词：Vascular endothelial growth factor （VEGF） P-SELECTIN Targeted contrast ultrasound-mediated gene transfection Heart function 
γ-Ray-Radiation-Scissioned Chitosan as a Gene Carrier and Its Improved in vitro Gene Transfection Performance被引量：1
《Chinese Journal of Chemical Physics》2017年第2期231-238,I0002,共9页林福星 曾琨 杨文秀 汪谟贞 荣洁琳 谢娟 赵宇 葛学武 
This work was supported by the National Natural Science Foundation of China （No.81171829, No.51473152, and No.51573175） and the Fundamental Research hinds for the Central Universities （WK2060200012, WK3450000001）. We also thank Prof. Li-hua Yang and Prof. Ye-zi You at the University of Science and Technology of China （USTC） for their kind help ill providing experimental reagents and instrunlents.
Chitosan （CS） is expected to be an ideal gene carrier for its high biosafety. In this work, CS with low molecular weight were prepared through the γ-ray radiation on the acetic acid solution of CS. The CS chains we...
关键词：CHITOSAN BIOCOMPATIBILITY Radiation scission Gene transfection 
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