financially supported by the National Basic Research Program(No.2014CB931900);the National Natural Science Foundation of China(No.21090352)
Chirality is a key factor in the biological activity of many biomolecules. Poly(L-lysine)(PLL), a polypeptide synthesized from L-lysine, is one of the mostly used cationic polymers for gene delivery. The effect of...
financially supported by the National Natural Science Foundation of China(Nos.51125014,51233003);the Ministry of Science and Technology of China(2011CB606202)
A disulfide bond containing polypeptide, PolyK6-R8, was designed and prepared by oxidative polymerization between terminal cysteinyl thiol groups of CHK6HC and CR8C. The molar ratio between CHK6HC and CR8C within obta...
Supported by the National Basic Research Program of China(No.2005CB623903).
Three cationic lipids with lysylated(1), histidylated(2), and arginylated(3) headgroups and cholesterol hydrophobic moiety were synthesized. The average sizes of liposomes and lipoplexes were around 100 and 160 ...