Acknowledgements This work was supported by grants from the Natural Science Foundation of Guangdong Province, China (No S2012010008748 and S2013010014715).
Aberrant activation of the PI3K/Akt/mTOR pathway contributes to the proliferation of malignant cells, and may confer resistance to chemotherapy in various malignancies, including acute myeloid leukemia (AML). Chemor...