supported by the National Natural Science Foundation(NNSF)of China(Nos.11871201,11871238 and 12001178)。
It is beyond dispute that cytotoxic T-lymphocytes(CTLs)exert a vital function in the host's antiviral defense mechanism.With the idea of the above factor and the logistic proliferation of CD4+T-cells,we establish a HT...
supported by the Deanship of Scientific Research(DSR);King Abdulaziz University,Jeddah,under grant no.(D-83-130-1443).
The main target of both human immunodeficiency virus type 1(HIV-1)and human Tlymphotropic virus type I(HTLV-I)is the CD4+T cell which is considered the key player in the immune system.Moreover,HIV-1 has another target...
Human immunodeficiency virus(HIV)and human T-Iymphotropic virus type I(HTLV-I)are two retroviruses that infect the susceptible CD4^(+)T cells.It is known that HIV and HTLV-I have in common a way of transmission throug...
The work was supported by the National Nature Science Foundation of China (No. 11871473).
This paper investigates the stochastic HTLV-I infection model with CTL immune response,and the corresponding deterministic model has two basic reproduction numbers.We consider the nonlinear CTL immune response for the...
Acknowledgments The authors would like to thank the reviewers' constructive suggestions which have improved the presentation of the paper. This research is supported by National Natural Science Foundation of China (No. 11371111), the Research Fund for the Doctoral Program of Higher Education of China (No. 20122302110044) and Shandong Provincial Natural Science Foundation, China (No. ZR2013AQ023).
In this paper, a HTLV-I infection model with two delays is considered. It is found that the dynamics of this model are determined by two threshold parameters R0 and R1, basic reproduction numbers for viral infection a...