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作品数：306被引量：941H指数：15
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相关机构：首都医科大学南华大学北京大学第一医院中国医科大学更多>>
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Hypoxia endothelial cells-derived exosomes facilitate diabetic wound healing through improving endothelial cell function and promoting M2 macrophages polarization被引量：2
《Bioactive Materials》2024年第3期157-173,共17页Peng Cheng Xudong Xie Liangcong Hu Wu Zhou Bobin Mi Yuan Xiong Hang Xue Kunyu Zhang Yuxiao Zhang Yiqiang Hu Lang Chen Kangkang Zha Bin Lv Ze Lin Chuanlu Lin Guandong Dai Yixin Hu Tengbo Yu Hankun Hu Guohui Liu Yingze Zhang 
supported by the National Science Foundation of China(No.82272491,No.82072444);Chinese Pharmaceutical Association Hospital Pharmacy department(No.CPA-Z05-ZC-2022-002);Grants from Hubei Province Unveiling Science and Technology Projects(No.2022-35).
It is imperative to develop and implement newer,more effective strategies to address refractory diabetic wounds.As of now,there is currently no optimal solution for these wounds.Hypoxic human umbilical vein endothelia...
关键词：Diabetic wound Hypoxic exosomes lncHAR1B KLF4 Macrophage polarization 
Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair被引量：14
《Bioactive Materials》2023年第6期477-496,共20页Han Sun Juan Xu Yangyufan Wang Siyu Shen Xingquan Xu Lei Zhang Qing Jiang 
supported by National Science Foundation of China(Grant No.32271409,82002370,31800806);National Basic Research Program of China(2021YFA1201404);China Postdoctoral Science Foundation(Grant No.2019M661806);Major Project of NSFC(81991514);Natural Science Foundation of Jiangsu Province(Grant No.BK20200117);Jiangsu postdoctoral research support project(Grant No.2021K059A);Program of Innovation and Entrepreneurship of Jiangsu Province,Jiangsu Provincial Key Medical Center Foundation,Jiangsu Provincial Medical Outstanding Talent Foundation,Jiangsu Provincial Medical Youth Talent Foundation and Jiangsu Provincial Key Medical Talent Foundation,the Fundamental Research Funds for the Central Universities(14380493,14380494);Changzhou Sci&Tech Program(Grant No.CJ20220103).
Large bone defects resulting from fractures and disease are a major clinical challenge,being often unable to heal spontaneously by the body’s repair mechanisms.Lines of evidence have shown that hypoxia-induced overpr...
关键词：Bone defect Hypoxic microenvironment Reactive oxygen species responsiveness Prolonged oxygen generation Brain and muscle arnt-like protein 1 
Small extracellular vesicles derived from hypoxic preconditioned dental pulp stem cells ameliorate inflammatory osteolysis by modulating macrophage polarization and osteoclastogenesis被引量：6
《Bioactive Materials》2023年第4期326-342,共17页Jun Tian Weiyang Chen Yuhua Xiong Qianer Li Siyi Kong Mengjie Li Chunfeng Pang Yu Qiu Zhezhen Xu Qimei Gong Xi Wei 
This work was supported by National Natural Science Foundation of China(No.81870750,81970925,81900994);the Guangdong Financial Fund for High-Caliber Hospital Construction(174-2018-XMZC-0001-03-0125/D-08).
Extensive macrophage inflammatory responses and osteoclast formation are predominant during inflammatory or infective osteolysis.Mesenchymal stem cell(MSC)-derived small extracellular vesicles(MSC-sEV)have been shown ...
关键词：Dental pulp stem cells Small extracellular vesicles Macrophage OSTEOCLAST Inflammatory osteolysis 
Upconverting nanoparticle-containing erythrocyte-sized hemoglobin microgels that generate heat,oxygen and reactive oxygen species for suppressing hypoxic tumors被引量：4
《Bioactive Materials》2023年第4期112-126,共15页Hanju Kim Johyun Yoon Hwang Kyung Kim Woo Tak Lee Nguyen Thi Nguyen Xuan Thien Le Eun-Hee Lee Eun Seong Lee Kyung Taek Oh Han-Gon Choi Yu Seok Youn 
This work was supported by a National Research Foundation of Korea(NRF)grants funded by the Korean government(No.NRF-2019R1A5A2027340);the Bio&Medical Technology Development Program of the National Research Foundation(NRF)funded by the Korean government(MSIT)(No.NRF-2022M3A9G8017220).
Inspired by erythrocytes that contain oxygen-carrying hemoglobin(Hb)and that exhibit photo-driven activity,we introduce homogenous-sized erythrocyte-like Hb microgel(μGel)systems(5-6μm)that can(i)emit heat,(ii)suppl...
关键词：Hemoglobin microgel Upconversion Photothermal therapy Photodynamic therapy Hypoxic tumors Oxygen-generation 
CXCR4-guided liposomes regulating hypoxic and immunosuppressive microenvironment for sorafenib-resistant tumor treatment被引量：10
《Bioactive Materials》2022年第11期147-161,共15页Yuehua Wang Zhenjie Wang Fei Jia Qing Xu Zhilin Shu Junlin Deng Aimin Li Meng Yu Zhiqiang Yu 
This research was financially supported by GDNRC[Guangdong nature resource center](2020)037;the National Natural Science Foundation of China(81773642,52073139);the Natural Science Foundation of Guangdong Province(2019A1515011619 and 2019A1515011498);Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,CAS(NSKF201819);Project of Traditional Chinese Medi-cine Bureau of Guangdong Province,China(NO.20203006);Science and Technology Program of Guangzhou,China(NO.202002030075).
Clinical sorafenib treatment could activate C-X-C receptor type 4(CXCR4)/stromal source factor-1α(SDF-1α)axis to aggravate intra-tumoral hypoxia of hepatocellular carcinoma(HCC),which further leads to progression,in...
关键词：Hepatocellular carcinoma Sorafenib resistance Hypoxia relief Immunotherapy Tumor targeting regulation 
Bioinspired porous microspheres for sustained hypoxic exosomes release and vascularized bone regeneration被引量：11
《Bioactive Materials》2022年第8期377-388,共12页Yike Gao Zuoying Yuan Xiaojing Yuan Zhuo Wan Yingjie Yu Qi Zhan Yuming Zhao Jianmin Han Jianyong Huang Chunyang Xiong Qing Cai 
the financial support from Beijing Natural Science Foundation(7212135);National Natural Science Foundation of China(NSFC)(11972001,11972002 and 12072001).
Exosomes derived from mesenchymal stem cells(MSCs)have demonstrated regenerative potential for cell-free bone tissue engineering,nevertheless,certain challenges,including the confined therapeutic potency of exosomes a...
关键词：Hypoxic exosomes Stem cells from human exfoliated deciduous teeth Porous microsphere Sustained release Vascularized bone regeneration 
Hypoxia response element-directed expression of bFGF in dental pulp stem cells improve the hypoxic environment by targeting pericytes in SCI rats被引量：4
《Bioactive Materials》2021年第8期2452-2466,共15页Sipin Zhu Yibo Ying Yan He Xingxing Zhong Jiahui Ye Zhiyang Huang Min Chen Qiuji Wu Yifan Zhang Ziyue Xiang Yurong Tu Weiyang Ying Jian Xiao Xiaokun Li Qingsong Ye Zhouguang Wang 
This study was partly funded by a grant the National Natural Science Foundation of China(81802235,81871503),Zhejiang Medical and Health Science and Technology Plan Project(2021KY212),and Wenzhou Basic Science Research Plan Project(Y2020050),Advanced Postdoctoral Programs of Zhejiang(zj2019030),China Postdoctoral Science Foundation(2019M662015),CAMS Innovation Fund for Medical Sciences(2019-I2M-5-028).
Cell-based transplantation strategies possess great potential for spinal cord injury(SCI)repair.Basic fibroblast growth factor(bFGF)has been reported to have multiple neuro-promoting effects on developing and adult ne...
关键词：Spinal cord injury Adeno-associated virus Basic fibroblast growth factor Dental pulp stem cell Vascular regulation Hypoxic microenvironment 
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