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Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-AS1411 nanocages
《Cancer Biology & Medicine》2022年第7期1047-1060,共14页Yu Han Yuming Yang Qiuyang Sun Bin Li Caixia Yue Yanlei Liu Jesús M.de la Fuente Daxiang Cui 
supported by the National Key Basic Research Program(973 Project)(Grant Nos.2015CB931802 and 2017FYA0205301);the Special Fund for Science and Technology Innovation of Shanghai Jiao Tong University(Grant Nos.YG2017MS70,YG2015MS62,and AF0300179);the Shanghai Municipal Bureau of Economy and Information Technology(Grant No.XC-ZXSJ-02-2016-05);the National Natural Scientific Foundation of China(Grant Nos.8202010801,81921002,81225010,81028009,and 31170961);the 863 Project of China(Grant No.2014AA020700);and the Shanghai Science and Technology Fund(Grant No.13NM1401500)。
Objective:Although great progress has been made in the field of siRNA gene therapy,safe,efficient,and targeted delivery of siRNA are still major challenges in siRNA therapeutics.Methods:We developed an up-conversion n...
关键词：Nanomaterials VEGF siRNA lung cancer gene therapy siRNA delivery 
Air pollution and inhalation exposure to particulate matter of different sizes in rural households using improved stoves in central China被引量：4
《Journal of Environmental Sciences》2018年第1期87-95,共9页Weijian Liu Guofeng Shen Yuanchen Chen Huizhong Shen Ye Huang Tongchao Li Yilong Wang Xiaofang Fu Shu Tao Wenxin Liu Yibo Huang-Fu Weihao Zhang Chunyu Xue Guangqing Liu Fuyong Wu Minghung Wong 
Natural Science Foundation Committee of China(No.41390240,41130754,and 41161160559);National Basic Research Program of China(No.2014CB441101);Science&Technology Basic Special Fund(No.2013FY111100-04);Global Alliance for Clean Cookstoves under PR-15-39809
Household air pollution is considered to be among the top environmental risks in China.To examine the performance of improved stoves for reduction of indoor particulate matter（PM） emission and exposure in rural hous...
关键词：Particulate matter Daily average exposure Size distribution Improved stoves Rural households in Central China 
Effect of moxa smoke produced during combustion of Aiye(Folium Artemisiae Argyi) on behavioral changes in mice inhaling the smoke被引量：12
《Journal of Traditional Chinese Medicine》2016年第6期805-811,共7页Yang Jia Zheng Xiaojun Jin Ran Han Li Ha Lue Li Jun Wang Lei Liu Ping Chu Zhusheng Huang Chang Chang Hongsheng Lao Lixing Zhao Baixiao 
Supported by the National Natural Science Foundation of China:Effect of Moxibustion on"Longevity Gene"SIRT1 Regulation in Aged Mice(No.81403449);NSFC Project:Effect of Moxibustion and its Therapeutic Factors on Mitochondrial Energy Metabolism and Apotosis Pathyway in APP/PS1Transgenic Alzheimer's Disease Mouse Model(No.81574068);National Program on Key Basic Research Project(973 Program):the Study of Components and Mechanisms of Artemisia and the Product and Moxibustion and Safety Evaluation(No.2009CB522906)
OBJECTIVE: To evaluate the effects that inhalation of the combustion products of the traditional Chinese herb Aiye(Folium Artemisiae Argyi) has on the central nervous system.METHODS: Forty Kunming mice(half male) were...
关键词：Artemisia Argyi Moxa smoke Central nervous system INHALATION 
Doxorubicin-loaded PLGA Microparticles with Internal Pores for Longacting Release in Pulmonary Tumor Inhalation Treatment被引量：2
《Chinese Journal of Polymer Science》2015年第7期947-954,共8页Tian-shi Feng 田华雨 Cai-na Xu Lin Lin Michael Hon-Wah Lam Hao-jun Liang Xue-si Chen 
financially supported by the National Natural Science Foundation of China(Nos.51222307,51303173,51390480,21474104 and 51403205);the Ministry of Science and Technology of China(International cooperation and communication program 2011DFR51090);Jilin Province Science and Technology Development Program(Nos.20120306,20130521011JH)
Doxorubicin（DOX） loaded poly（lactic-co-glycolic acid）（PLGA） microparticles with internal pores（MP-D） were developed for long-acting release in pulmonary inhalation treatment. The PLGA microparticles exhibited ...
关键词：Doxorubicin Poly（lactic-co-glycolic acid） Internal pores Long-acting release Pulmonary inhalation 
A combined dynamic inhalation device designed for moxa-smoking toxicity testing被引量：3
《Journal of Traditional Chinese Medicine》2015年第1期90-98,共9页Lan Lei Chang Xiaorong Zhang Guoshan Shi Jia 
Supported by the Study of Warming Effect of Moxibustion and its Principle(the Major National Basic Research Program of China,No.2009CB522904);the Study of Safety of Moxibustion Products Based on High Performance Liquid Chromatography-Mass Spectrometry in Metabonomics Technology(Hunan Graduate Student Innovation Fund,No.CX2010B342)
OBJECTIVE： To design a combined dynamic inhalation device for testing the toxicity induced by moxa smoking. METHODS： The new apparatus （Patent No. 201120101911.5） includes air renewal and recycling systems, a gas ...
关键词：MOXIBUSTION INHALATION TOXICITY HSP70 heat-shock proteins 
Spatial concentration,congener profiles and inhalation risk assessment of PCDD/Fs and PCBs in the atmosphere of Tianjin,China被引量：18
《Chinese Science Bulletin》2013年第9期971-978,共8页DING Lei LI YingMing WANG Pu LI XiaoMin ZHAO ZongShan RUAN Ting ZHANG QingHua 
supported by the Ministry of Environmental Protection of China for the Project of Toxic Substances in the Atmosphere and Their Effect to the Soil,the National Basic Research Program of China(2009CB421600);the National Natural Science Foundation of China(20890111,20907059)
Polychlorinated dibenzo-p-dioxins/dibenzofurans(PCDD/Fs) and polychlorinated biphenyls(PCBs) were monitored in a seasonal passive sampling scheme during June 2008 and January 2009 to investigate the spatial concentrat...
关键词：PCDD 风险评估 多氯联苯 空间集聚 天津市 中国 集中度 气氛 
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