INSULIN_RESISTANCE

作品数:774被引量:3602H指数:25
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相关作者:李雪飞张思仲刘合焜陈素云田浩明更多>>
相关机构:南京医科大学北京大学第一医院北京大学四川大学华西医院更多>>
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Hemoglobin glycation index among adults with type 1 diabetes:Association with double diabetes features
《World Journal of Diabetes》2025年第4期153-165,共13页Xiao-Lin Ji Min Yin Chao Deng Li Fan Yu-Ting Xie Fan-Su Huang Yan Chen Xia Li 
Supported by the National Key R D Program of China,No.2022YFC2010102;Natural Science Foundation of Hunan Province,No.2021JC0003;National Natural Science Foundation of China,No.82070812;the Sinocare Diabetes Foundation,No.LYF2022039.
ACKGROUND The hemoglobin glycation index(HGI)represents the discrepancy between the glucose management indicator(GMI)based on mean blood glucose levels and laboratory values of glycated hemoglobin(HbA1c).The HGI is a ...
关键词:Type 1 diabetes Double diabetes Insulin resistance Hemoglobin glycation index Advanced glycation end products Diabetic complications 
Cross-sectional study of the association between triglyceride glucose-body mass index and obstructive sleep apnea risk
《World Journal of Diabetes》2025年第3期65-75,共11页Li Gong Ming Su Jing-Han Xu Zhen-Fei Peng Lin Du Ze-Yao Chen Yu-Zhou Liu Lu-Cia Chan Yin-Luan Huang Yu-Tian Chen Feng-Yi Huang Chun-Li Piao 
Supported by Sanming Project of Medicine in Shenzhen,No.SZZYSM202202010。
BACKGROUND The triglyceride glucose-body mass index(TyG-BMI)is a novel indicator of insulin resistance(IR).Obstructive sleep apnea(OSA)is a prevalent disorder characterized by recurrent complete or partial collapse of...
关键词:Obstructive sleep apnea Triglyceride glucose-body mass index Insulin resistance CROSS-SECTIONAL National Health and Nutrition Examination Surveys 
Role of duodenal mucosal resurfacing in controlling diabetes in rats
《World Journal of Diabetes》2025年第3期243-259,共17页Li-Juan Nie Zhe Cheng Yi-Xian He Qian-Hua Yan Yao-Huan Sun Xin-Yi Yang Jie Tian Peng-Fei Zhu Jiang-Yi Yu Hui-Ping Zhou Xi-Qiao Zhou 
Supported by the National Natural Science Foundation of China,No.82474318;the Jiangsu Administration of Traditional Chinese Medicine,No.zt202105;Subject of Jiangsu Province Hospital of Chinese Medicine,No.Y2021rc22;a Research Career Scientist。
BACKGROUND The duodenum plays a significant role in metabolic regulation,and thickened mucous membranes are associated with insulin resistance.Duodenal mucosal resurfacing(DMR),a new-style endoscopic procedure using h...
关键词:Type 2 diabetes Duodenal mucosal resurfacing Gut microbiota Insulin resistance Blautia Gastric inhibitory peptide Glucagon-like peptide 1 
Electroacupuncture relieves type 2 diabetes by regulating gut microbiome
《World Journal of Diabetes》2025年第3期284-288,共5页Ya-Jing Yang Xu-Chang Zhou Hao-Ran Tian Feng-Xia Liang 
Cumulative studies have shown that the composition of the gut microbiome is strongly associated with the development of type 2 diabetes mellitus(T2DM).Electroacupuncture(EA)therapy has been reported to alleviate vario...
关键词:ELECTROACUPUNCTURE Type 2 diabetes mellitus Intestinal flora Intestinal microbiota Insulin resistance 
Tacrolimus induces insulin receptor substrate 1 hyperphosphorylation and inhibits mTORc1/S6K1 cascade in HL7702 cells
《World Journal of Diabetes》2025年第2期175-182,共8页Hao-Yan Li Yi Wang Min Ran Fei Gao Bo-Yu Zhu Hai-Ying Xiao Chun Xu 
BACKGROUND Tacrolimus(FK506)is a key calcineurin inhibitor used to prevent organ transplant rejection and is effective in improving graft survival.However,it is linked to hyperglycemia and insulin resistance,contribut...
关键词:TACROLIMUS Insulin resistance DYSLIPIDEMIA Ribosomal protein S6 kinase beta-1 Glucose metabolism 
Don´t give up on mitochondria as a target for the treatment of diabetes and its complications
《World Journal of Diabetes》2024年第10期2015-2021,共7页Christian Cortés-Rojo Manuel Alejandro Vargas-Vargas 
Supported by Instituto de Ciencia,Tecnología e Innovación-Gobierno del Estado de Michoacán,México,No.ICTI-PICIR23-063;Programa Proyectos de Investigación Financiados 2024,Coordinación de Investigación Científica,Universidad Michoacana de San Nicolás de Hidalgo,México.
In this editorial,we discuss an article by Wang et al,focusing on the role of mitochondria in peripheral insulin resistance and insulin secretion.Despite numerous in vitro and pre-clinical studies supporting the invol...
关键词:Diabetes mellitus Insulin resistance MITOCHONDRION Mitochondrial dysfunction MITOQ MitoTEMPO SKQ Elamipretide Mitochondria transplantation Glycemic control 
Exploring the genetic basis of childhood monogenic diabetes
《World Journal of Diabetes》2024年第9期1829-1832,共4页Debmalya Sanyal 
Monogenic diabetes is caused by one or even more genetic variations,which may be uncommon yet have a significant influence and cause diabetes at an early age.Monogenic diabetes affects 1%to 5%of children,and early det...
关键词:Monogenic diabetes Genetic mutation Insulin resistance Beta-cell function Diabetes mellitus 
Insulin resistance as the molecular link between diabetes and Alzheimer's disease被引量:2
《World Journal of Diabetes》2024年第7期1430-1447,共18页Mona Mohamed Ibrahim Abdalla 
Diabetes mellitus(DM)and Alzheimer's disease(AD)are two major health concerns that have seen a rising prevalence worldwide.Recent studies have indicated a possible link between DM and an increased risk of developing A...
关键词:Alzheimer's disease Insulin resistance OBESITY DEMENTIA DIABETES Metabolic syndrome 
Therapeutic effects of Lingguizhugan decoction in a rat model of high-fat diet-induced insulin resistance
《World Journal of Diabetes》2024年第6期1291-1298,共8页Xiao-Ming Liu Shi-Qing Yuan Ying Ning Shi-Jia Nie Xu-Qiong Wang Hong-Yi Jia Xiu-Li Zheng 
Supported by the Preresearch Project of the National Natural Science Foundation of China,No.ZRYY1906;the Applied Basic Research Project of the Science and Technology Department of Sichuan Province,No.2021YJ0154;the Talent Research Promotion Plan of Xinglin Scholars of Chengdu University of Traditional Chinese Medicine,No.QNXZ2019035;the Chengdu University of Traditional Chinese Medicine‘Xinglin Scholars'subject talent research promotion Program(young scholars),No.QNXZ2019037.
BACKGROUND Lingguizhugan(LGZG)decoction is a widely used classic Chinese medicine formula that was recently shown to improve high-fat diet(HFD)-induced insulin resistance(IR)in animal studies.AIM To assess the therape...
关键词:Lingguizhugan decoction High-fat diet-induced insulin resistance Amino acid metabolism S6K1 
Growth hormone improves insulin resistance in visceral adipose tissue after duodenal-jejunal bypass by regulating adiponectin secretion
《World Journal of Diabetes》2024年第6期1340-1352,共13页Zi-Tian Liu Guang-Wei Yang Xiang Zhao Shuo-Hui Dong Yang Jiao Zheng Ge Ao Yu Xi-Qiang Zhang Xin-Zhen Xu Zhi-Qiang Cheng Xiang Zhang Ke-Xin Wang 
Supported by National Natural Science Foundation of China(General Program),No.82070852 and No.82270901.
BACKGROUND The mechanism of improvement of type 2 diabetes after duodenal-jejunal bypass(DJB)surgery is not clear.AIM To study the morphological and functional changes in adipose tissue after DJB and explore the poten...
关键词:Growth hormone Insulin resistance Bariatric surgery Adipose tissue ADIPONECTIN 
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