Ferroptosis is an atypical cell death modality involving the oxidative destruction of cellular membranes following the failure of a glutathione-dependent antioxidant system.A recent paper by Wang et al. demonstrates t...
Interferon-gamma (IFN-γ) is a major proinflammatory effector and regulatory cytokine produced by activated T cells and NK cells. IFN-γ has been shown to play pivotal roles in fundamental immunological processes su...
Acknowledgements Research in the author's laboratory was supported by grants from the Israel Science Foundation (537/03) and the Deutsche Forschungsgemeinschaft (H0- 1116),
PKR, the interferon (IFN)-inducible protein kinase activated by double-stranded RNA, inhibits translation by phosphorylating the initiation factor eIF2α chain. Uniquely, human IFN-γ mRNA uses local activation of P...