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作品数：96被引量：295H指数：9
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相关领域：生物学医药卫生更多>>
相关作者：高淑芳杜艳红郝强薛赓孙树汉更多>>
相关机构：第二军医大学暨南大学广州科技职业技术学院第四军医大学更多>>
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HOXB6 down-regulation induced by retinoic acid pathway repression leads to chondrocyte proliferation inhibition and apoptosis in microtia
《Genes & Diseases》2025年第3期23-26,共4页Run Yang Xin Chen Siyi Wu Chenlong Li Ying Chen Yaoyao Fu Aijuan He Duan Ma Jing Ma Tianyu Zhang 
supported by the National Natural Science Foundation of China(No.82271889,82371173);the National Key Research and Development Program of China(No.2021YFC2701000);the Natural Science Foundation Project of Shanghai Science and Technology Innovation Action Plan(China)(No.23ZR1409400);Shanghai Science and Technology Commission of China(No.21DZ2200700).
Microtia,a congenital malformation affecting the external and middle ear,arises from disruptions during the development of embryonic branchial arches and cranial neural crest cells(CNCCs),making it the second most pre...
关键词：aberrant gene expression skeletal patterningand congenital malformation maxillofacial birth defect hoxb conductive hearing loss retinoic acid pathway embryonic branchial arches 
Spliceosomal repression:unleashing human cell totipotency
《Signal Transduction and Targeted Therapy》2024年第10期4162-4164,共3页Felipe F.Lüttmann Kee-Pyo Kim Johnny Kim 
K.-P.K.acknowledges support from the Korean Fund for Regenerative Medicine(KFRM)grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Health&Welfare)(22A0203L1);J.K.acknowledges support from the German Research Council(DFG,Project 496710327);Federal Ministry for Education and Research(BMBF)with the grant number 03ZU1202FA.
In a recent publication in Cell,Li et al.reported that inhibiting the spliceosome in human pluripotent stem cells(hPSCs)can induce a stable totipotent state.1 This study signifies the importance of post-transcriptiona...
关键词：INHIBITING IMPLANTATION 
Interplay of RNA-binding proteins controls germ cell development in zebrafish
《Journal of Genetics and Genomics》2024年第9期889-899,共11页De-Li Shi 
The specification of germ cells in zebrafish mostly relies on an inherited mechanism by which localized maternal determinants,called germ plasm,confer germline fate in the early embryo.Extensive studies have partially...
关键词：GERMPLASM Primordialgerm cell Germlinestem cell GAMETOGENESIS ZEBRAFISH RNA-binding protein Posttranscriptional gene expression Translational activation and repression 
Aldehyde dehydrogenase 2 family member repression promotes colorectal cancer progression by JNK/p38 MAPK pathways-mediated apoptosis and DNA damage
《World Journal of Gastrointestinal Oncology》2024年第7期3230-3240,共11页Miao Yu Qian Chen Yi-Ping Lu 
Supported by Beijing Municipal Hospital Research and Cultivation Program Project,No.PZ2022008.
BACKGROUND Aldehyde(ALDH2)dysfunction has been verified to contribute to human cancers.AIM To investigate the molecular mechanism and biological function of ALDH2 in colorectal cancer(CRC)progression.METHODS Human CRC...
关键词：Aldehyde dehydrogenase 2 family member Colorectal cancer ACETALDEHYDE Apoptosis DNA damage JNK/p38 MAPK 
AtVQ25 promotes salicylic acid-related leaf senescence by fine-tuning the self-repression of AtWRKY53
《Journal of Integrative Plant Biology》2024年第6期1126-1147,共22页Qi Tan Mingming Zhao Jingwei Gao Ke Li Mengwei Zhang Yunjia Li Zeting Liu Yujia Song Xiaoyue Lu Zhengge Zhu Rongcheng Lin Pengcheng Yin Chunjiang Zhou Geng Wang 
supported by grants from the National Natural Science Foundation of China(31970199);the Natural Science Fund for Distinguished Young Scholars of Hebei Province(C2022205015);the Central Government Guides Local Science and Technology Development Project(216Z2901G);the S&T Program of Hebei(21322915D);the Natural Science Foundation of Hebei Province(C2022205038,C2021205013,and C2023205049)。
Most mechanistic details of chronologically ordered regulation of leaf senescence are unknown.Regulatory networks centered on AtWRKY53 are crucial for orchestrating and integrating various senescence-related signals.N...
关键词：AtWRKY53 leaf senescence salicylic acid transcriptional regulation VQ motif-containing proteins 
Chemotherapy induces breast cancer stem cell enrichment through repression of glutathione S-transferase Mu被引量：2
《Genes & Diseases》2024年第2期528-531,共4页Jing He Yiran Yu Yilin He Jie He Guangyu Ji Haiquan Lu 
supported by the Natural Science Foundation of Shandong Province,China(No.ZR2021YQ50,Excellent Young Scholars Program)
Triple-negative breast cancer(TNBC)has aggressive characteristics as exemplified by the high risk of recurrence,metastasis,and patient mortality.1 Cytotoxic chemotherapy may reduce tumor burden initially,but leave beh...
关键词：CHEMOTHERAPY BREAST METASTASIS 
A dephosphorylation-dependentmolecular switch for FT repression mediates flowering in Arabidopsis
《Plant Communications》2024年第3期167-178,共12页Yu Zhang Changmei Hua Jian Xuan Kiang Lisha Shen 
supported by the National Research Foundation Competitive Research Programme (NRF-CRP22-2019-0001);the Singapore Food Story R&D Programme (SFS_RND_SUFP_001_04);intramural research support from Temasek Life Sciences Laboratory.
The reproductive success offlowering plants relies greatly on precise timing of thefloral transition,which isnely modulated by a complex network offloral regulators.As a mainfloral integrator,FLOWERING LOCUS T(FT)is a...
关键词：CTD phosphatase MYB protein FLORIGEN FT FLOWERING ARABIDOPSIS 
Drought-triggered repression of miR166 promotes drought tolerance in soybean
《The Crop Journal》2024年第1期154-163,共10页Chen Zhao Jingjing Ma Chen Yan Yu Jiang Yaohua Zhang Yudan Lu Ye Zhang Suxin Yang Xianzhong Feng Jun Yan 
supported by grants from the Projects of Science and Technology of Shanghai(18PJ1402800,20ZR1417900,and 22N11900400);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA24030303);Hainan Yazhou Bay Seed Laboratory and China National Seed Group(B23YQ1502).
Drought stress limits agricultural productivity worldwide.Identifying and characterizing genetic components of drought stress-tolerance networks may improve crop resistance to drought stress.We show that the regulator...
关键词：SOYBEAN Drought stress miRNA ABA signaling 
Low temperature-mediated repression and far-red light-mediated induction determine morning FLOWERING LOCUS T expression levels被引量：1
《Journal of Integrative Plant Biology》2024年第1期103-120,共18页Hayeon Kim Hye Won Kang Dae Yeon Hwang Nayoung Lee Akane Kubota Takato Imaizumi Young Hun Song 
supported by the Japan Society for the Promotion of Science(JSPS)KAKENHI grant(No.19K16170 and No.23K05817 to A.K.);National Institutes of Health(NIH)(No.R01GM079712 to T.I.);the National Research Foundation(NRF)of Korea grant funded by the Korean Government(MSIT)(No.NRF-2020R1A2C1014655 andNo.NRF-2021R1A4A1032888 to Y.H.S.).
In order to flower in the appropriate season,plants monitor light and temperature changes and alter downstream pathways that regulate florigen genes such as Arabidopsis(Arabidopsis thaliana)FLOWERING LOCUS T(FT).In Ar...
关键词：far-red light FLOWERING LOCUS T flowering time GIGANTEA low night-to-morning temperature natural long days phytochrome A red to far-red ratio ZEITLUPE 
Artemisinins inhibit oral candidiasis caused by Candida albicans through the repression on its hyphal development被引量：1
《International Journal of Oral Science》2023年第4期613-625,共13页Xiaoyue Liang Ding Chen Jiannan Wang Binyou Liao Jiawei Shen Xingchen Ye Zheng Wang Chengguang Zhu Lichen Gou Xinxuan Zhou Lei Cheng Biao Ren Xuedong Zhou 
the National Natural Science Foundation of China grants(81870778,82071106,82271033,81991500,81991501,82201046);Key Research and Development Projects of Science and Technology Department of Sichuan Province(2021YFQ0064);Technology Innovation R&D Project of Chengdu(2022-YF05-01401-SN);Applied Basic Research Programs of Sichuan Province(2020YJ0227).
Candida albicans is the most abundant fungal species in oral cavity. As a smart opportunistic pathogen, it increases the virulence byswitching its forms from yeasts to hyphae and becomes the major pathogenic agent for...
关键词：INS DRUGS inhibited 
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