BACKGROUND Cardiovascular diseases are the first cause of death in the world.Ischemic heart disease is the main cause of heart failure.New approaches are continuously sou-ght to identify better therapeutic success.The...
BACKGROUND Bleedings are an independent risk factor for subsequent mortality in patients with acute coronary syndromes(ACS)and in those undergoing percutaneous coronary intervention.This represents a hazard equivalent...
Chronic ischemic mitral valve regurgitation is a result of disturbed left ventricular geometry secondary to myocardial ischemia in the absence of intrinsic mitral valve pathology. It is a common complication after myo...
Supported by NIH grants,No.HL061974(to Gary E Shull),No.R01HL136025(to Yigang Wang),No.P30ES006096(to Mario Medvedovic);funds from the Center for Clinical and Translational Science and Training,University of Cincinnati(to Gary E Shull);a Research Innovation Seed Grant from the University of Cincinnati(to Gary E Shull and John N Lorenz)
AIM To investigate the hypothesis that cardiomyocytespecific loss of the electrogenic NBCe1 Na^+-HCO3^- cotransporter is cardioprotective during in vivo ischemiareperfusion(IR)injury.METHODS An NBCe1 (Slc4a4 gene) con...
Neural elements of the intrinsic cardiac nervous system transduce sensory inputs from the heart, blood vessels and other organs to ensure adequate cardiac function on a beat-to-beat basis. This inter-organ crosstalk i...
Supported by The Pfizer Health Research Foundation
The aim of this review was to summarize the concept of appropriate use criteria(AUC) regarding percutaneous coronary intervention(PCI) and document AUC use and impact on clinical practice in Japan, in comparison with ...
Myocardial infarction is the most common cause of congestive heart failure. Novel strategies such as directly reprogramming cardiac fibroblasts into cardiomyocytes are an exciting area of investigation for repair of i...
In remote ischemic conditioning(RIC), several cycles of ischemia and reperfusion render distant organ and tissues more resistant to the ischemia-reperfusion injury. The intermittent ischemia can be applied before the ...
Acute coronary syndromes remain a leading single cause of death worldwide. Therapeutic strategies to treat cardiomyocyte threatening ischemia/reperfusion injury are urgently needed. Remote ischemic preconditioning(r I...