This study aims to investigate the potential impact of inhibitors targeting the papain-like protease(PLpro)of SARS-CoV-2 on viral replication and the host immune response.A mathematical model was developed to simulate...
Nine new germacranolides,sylvaticalides A−H(1-9),and three known analogues(10-12)were isolated from the aeri-al part of Vernonia sylvatica.Their structures were established using comprehensive spectroscopic analysis,i...
This work was supported by the National Natural Science Foundation of China(32170144).
Enterovirus D68(EV-D68)can cause respiratory diseases and acute flaccid paralysis,posing a great threat to public health.Interferons are cytokines secreted by host cells that have broad-spectrum antiviral effects,indu...
supported by the Natural Science Foundation of Guangdong Basic and Applied Basic Research Fund(2022A1515012657);Guangzhou Science and Technology Plan Project(202002030218);National Natural Science Foundation of China(31872426);South China Agricultural University high-level talent launch project;Guangdong Provincial Promotion Project on Preservation and Utilization of Local Breed of Livestock and Poultry(No.2018-143);Innovation and Entrepreneurship Training Program for College Students in Guangdong Province(S202110564098).
Cholesterol-25-hydroxylase(CH25H)has been identified as an interferon-stimulated gene(ISG)in mammals that exerts its antiviral effects by catalyzing the conversion of cholesterol to 25-hydroxycholesterol(25HC).However...
supported by National Natural Science Foundation of China,China(No.31970887);Guangdong Science and Technology Department,China(No.2018B030337001);Guangdong Basic and Applied Basic Foundation(No.2019A1515011336)
Zika virus(ZIKV) infection can cause severe neurological diseases including neonatal microcephaly and GuillainBarre syndrome. Long noncoding RNAs(lncRNAs) are the by-products of the transcription process, which are co...