目的:探讨结直肠癌患者癌组织中P53、T细胞免疫球蛋白和ITIM结构域(T-cell immunoreceptor with immunoglobulin and ITIM domains,TIGIT)、细胞程序性死亡-配体1(Programmed cell death-ligand 1,PD-L1)的表达。方法:回顾性纳入2022年1...
supported by the National Key Research and Development Program of China(No.2021YFC2700903);the National Natural Science Foundation of China(Nos.81672791 and 81872300);the Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China(No.LR18C060002);the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(No.LHDMY22H160006);the ZJU-QILU Joint Research Institute and Qilu Group.
Immunological evasion is one of the defining characteristics of cancers,as the immune modification of an immune checkpoint(IC)confers immune evasion capabilities to tumor cells.Multiple ICs,such as programmed cell dea...
National Natural Science Foundation of China(No.82102469)
Objective:To analyze the proportion of peripheral regulatory T cells(Tregs)and the expression of the immune checkpoint molecules T-cell immunoglobulin and ITIM domain(TIGIT)and CD226 on Tregs in patients with recurren...