Supported by the National Basic Research Program of China (Grant No. 2006CB910303);National Natural Science Foundation of China (Grant Nos. 30730032, 10332060);Knowledge Innovation Program of Chinese Academy of Sciences (Grant No. KJCX2-YW-L08);National High-Tech Research and De-velopment Program of China (Grant No. 2007AA02Z306)
L-selectin plays a crucial role in inflammation cascade by initiating the tethering and rolling of leukocytes on endothelium wall. While many L-selectin molecules are rapidly shed from the cell surface upon activation...