云南高校图书馆联盟文献共享服务平台- K-RAS

K-RAS: 作品数：494被引量：1552H指数：16; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：李兆申周国雄陈杰许国铭白莉更多>>; 相关机构：第二军医大学中国人民解放军总医院华中科技大学北京协和医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金中国博士后科学基金广东省科技计划工业攻关项目国家教育部博士点基金更多>>

Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival被引量：3: 《World Journal of Gastroenterology》2015年第21期6621-6630,共10页Hui-Lin Ye Dou-Dou Li Qing Lin Yu Zhou Quan-Bo Zhou Bing Zeng Zhi-Qiang Fu Wen-Chao Gao Yi-Min Liu Rui-Wan Chen Zhi-Hua Li Ru-Fu Chen; AIM:To analyze RASSF6 expression in pancreatic ductal adenocarcinoma(PDAC) and to determine whether RASSF6 has an independent prognostic value in PDAC.METHODS:We studied RASSF6 expression in 96 histologically confirme...; 关键词：PANCREATIC cancer PANCREATIC ductaladenocarcinoma PROGNOSTIC marker RASSF6 K-RAS IMMUNOHISTOCHEMISTRY SURVIVAL analysis

Comparative study of mutations in SNP loci of K-RAS, hMLH1 and h MSH2 genes in neoplastic intestinal polyps and colorectal cancer被引量：2: 《World Journal of Gastroenterology》2014年第48期18338-18345,共8页Zhi-Hui Yan Li-Hong Cui Xiao-Hui Wang Chao Li Xing He; Supported by Capital Public Health Project Cultivation Program,No.Z111107067311051; AIM: To clarify the molecular mechanism involved in pathogenesis of colorectal cancer as well as clinical significance of genetic analysis of histological samples.; 关键词：Neoplastic intestinal polyp Colorectal cancer Single nucleotide polymorphisms K-RAS HMLH1 hMSH2

Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large intestinal carcinoma被引量：4: 《World Journal of Gastroenterology》2014年第35期12542-12550,共9页Jia-Ding Mao Pei Wu Jian-Xiong Huang Jian Wu Guang Yang; Supported by Natural Science Foundation of Anhui Province,No.1408085MH148;Natural Science Fund of Education Bureau of Anhui Province,No.kj2010b242;Natural Science Fund of Wannan Medical College,No.wk2012zf02;the key science and technology project of Wuhu City,No.health-2-4; AIM: To explore the role and mechanisms of extracellular signal-regulated protein kinase-mitogen-activated protein kinase (ERK-MAPK) signaling in pentagastrin-regulated growth of large intestinal carcinoma.; 关键词：GASTRIN Mitogen-activated protein kinase Extracellular signal-regulated protein kinase 1/2 K-RAS Large intestinal carcinoma

Mouse models of pancreatic cancer被引量：8: 《World Journal of Gastroenterology》2012年第12期1286-1294,共9页Marta Herreros-Villanueva Elizabeth Hijona Angel Cosme Luis Bujanda; Supported by Instituto de Salud Carlos (CIBERehd); Pancreatic cancer is one of the most lethal of human malignancies ranking 4th among cancer-related death in the western world and in the United States,and potent therapeutic options are lacking.Although during the las...; 关键词：K-RAS Mouse models TRANSGENIC Pancre-atic cancer XENOGRAFTS

Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients被引量：30: 《World Journal of Gastroenterology》2011年第6期809-816,共8页Hong Shen Ying Yuan Han-Guang Hu Xiao-Xian Ye Mo- Dan Li Xian Zhong Wei-Jia Fang Shu Zheng; Supported by The Department of Education of Zhejiang Province of China,grant No.Y200804314;the Zhejiang Provincial Natural Science Foundation,grant No.R2090353;the Department of Science and Technology of Zhejiang Province,grant No.2008C33039;the Chinese Ministry of Health,grant No.N20100148; AIM:To identify and assess mutations in the K-ras and BRAF genes in a cohort of Chinese patients with colorectal cancer (CRC) for their association with various clinicopathological parameters and prognosis.METHODS:Gen...; 关键词：K-RAS BRAF Colorectal cancer MUTATION

Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients被引量：4: 《World Journal of Gastroenterology》2010年第38期4823-4831,共9页Inti Zlobec Francesca Molinari Vittoria Martin Luca Mazzucchelli Piercarlo Saletti Rosangela Trezzi Sara De Dosso Tatjana Vlajnic Milo Frattini Alessandro Lugli; AIM:To investigate whether the evaluation of tumor budding can complement K-RAS analysis to improve the individualized prediction of response to anti-epidermal growth factor receptor based therapies in metastatic colo...; 关键词：Anti-epidermal growth factor receptor therapy Colorectal cancer K-RAS PROGNOSIS Tumor budding

Enhanced therapeutic effects for human pancreatic cancer by application K-ras and IGF-IR antisense oligodeoxynucleotides被引量：10: 《World Journal of Gastroenterology》2008年第33期5176-5185,共10页Yong-Mei Shen Xiao-Chun Yang Chen Yang Jun-Kang Shen; Social development foundation of Suzhou, China, No. SZD0614;Young teacher foundation of Soochow University;Foundation of health department of Jiangsu Province, China, No. Z200622; AIM: To investigate the combined effects of K-ras antisense oligodeoxynucleotide (K-ras ASODN) specif ic to GTT point mutation at codon 12 and type Ⅰ insulin-like growth factor receptor (IGF-IR) antisense oligodeoxyn...; 关键词：Pancreatic cancer Antisense oligodeoxy-nucleotide K-RAS Type I insulin-like growth factor receptor Patu8988

Genetic changes of p53,K-ras,and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary被引量：9: 《World Journal of Gastroenterology》2008年第1期70-75,共6页Masayuki Nagahashi Yoichi Ajioka Istvan Lang Zoltan Szentirmay Miklos Kasler Hiroto Nakadaira Naoyuki Yokoyama Gen Watanabe Ken Nishikura Toshifumi Wakai Yoshio Shirai Katsuyoshi Hatakeyama Masaharu Yamamoto; AIM： To disclose geographic differences in genetic changes involved in gallbladder carcinogenesis between two distinct high-incidence areas of Japan and Hungary. METHODS： We examined 42 cases of gallbladder carcinom...; 关键词：GALLBLADDER Gallbladder Neoplasms K-RAS Microsatellite instability P53

Involvement of Krüppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma: 《World Journal of Gastroenterology》2007年第29期3932-3938,共7页Shinichi Mukai Toru Hiyama Shinji Tanaka Masaharu Yoshihara Koji Arihiro Kazuaki Chayama; Supported in part by a Grant from the Japanese Society of Gastrointestinal Endoscopy, Chugoku Branch; AIM： To examine Kruppel-like factor 6 （KLF6） mutations in nonpolypoid-type tumors and alterations of K-ras, p53, and B-raf in relation between mutation and morphologic type, particularly nonpolypoid-type colorectal...; 关键词：Nonpolypoid colorectal carcinoma KLF6 p53 K-RAS B-RAF

Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer被引量：18: 《World Journal of Gastroenterology》2007年第27期3714-3720,共7页C Salek L Benesova M Zavoral V Nosek L Kasperova M Ryska R Strnad E Traboulsi M Minarik; Internal Grant Agency of the Ministry of Health, Czech Republic, No. 8027-3; AIM： To establish an optimum combination of molecular markers resulting in best overall diagnostic sensitivity and specificity for evaluation of suspicious pancreatic mass. METHODS： Endoscopic ultrasound （EUS）-gui...; 关键词：Pancreatic cancer Chronic pancreatitis Endoscopic ultrasound-guided fine-needle aspiration Molecular markers Loss of heterozygosity

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