XENOGRAFTS

作品数：103被引量：309H指数：9
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相关领域：医药卫生生物学更多>>
相关作者：李吉友黄信孚姚丽华李志洪柯扬更多>>
相关机构：北京肿瘤医院北京大学浙江省医学科学院杭州市第一人民医院更多>>
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相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划国家科技支撑计划更多>>
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Continuous immunosuppression is required for suppressing immune responses to xenografts in non‑human primate brains
《Cell Regeneration》2024年第1期305-314,共10页Su Feng Ting Zhang Zhengxiao He Wenchang Zhang Yingying Chen Chunmei Yue Naihe Jing 
National Key Basic Research and Development Program of China(2019YFA0801402,2018YFA0107200,2018YFA0801402,2018YFA0800100);Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020501,XDA16020404);National Natural Science Foundation of China(32130030,31900454).
Continuous immunosuppression has been widely used in xenografts into non-human primate brains.However,how immune responses change after transplantation in host brains under continuous immunosuppressive adminis-tration...
关键词：Cell transplantation XENOGRAFT Immune response Non-human primate brain Human induced neural stem/progenitor cells(iNPCs) 
SMG-1 serves as a prognostic indicator for the radiotherapy response in head and neck squamous cell carcinoma xenografts and patients
《Acta Biochimica et Biophysica Sinica》2024年第12期1891-1894,共4页Xiaofeng Wang Yuxia Zou Ren-Bo Ding Xueying Lyu Yuanfeng Fu Xuejun Zhou Zhihua Sun Jiaolin Bao 
supported by the grants from the Hainan Provincial Natural Science Foundation of China(Nos.820MS141,822RC831,822QN300,and 822RC649);the National Natural Science Foundation of China(Nos.82104057,82360504,and 82203206);the Hainan University Collaborative Innovation Center Research Fund(No.XTCX2022JKB01);the Hainan“Nanhai New Star”Project(No.202309009).
Head and neck cancer(HNC)is one of the most common types of malignant cancer worldwide.These cancers originate in the oral cavity,oropharynx,larynx,hypopharynx,nasopharynx and sinonasal tract.The most common HNC type ...
关键词：RADIOTHERAPY PATIENTS SQUAMOUS 
Acellular nerve xenografts based on supercritical extraction technology for repairing long-distance sciatic nerve defects in rats被引量：1
《Bioactive Materials》2022年第12期300-320,共21页Shuai Wei Qian Hu Jianxiong Ma Xiu Dai Yu Sun Gonghai Han Haoye Meng Wenjing Xu Lei Zhang Xinlong Ma Jiang Peng Yu Wang 
the National Key R&D Program of China(2019YFA0110704);Medical Research and Development Projects(AWS17J005);the National Key R&D Program of China(2017YFA0104702);we are very grateful to the professional supercritical extraction equipment and technical support provided by Joel Hi-Tech(Dalian,China)Co.,Ltd.
Compared to conventional artificial nerve guide conduits (NGCs) prepared using natural polymers or synthetic polymers, acellular nerve grafts (ACNGs) derived from natural nerves with eliminated immune components have ...
关键词：Peripheral nerve regeneration Acellular nerve xenograft Supercritical extraction Peripheral nerve injury Nerve defect 
Novel dual inhibitor for targeting PIM1 and FGFR1 kinases inhibits colorectal cancer growth in vitro and patient-derived xenografts in vivo被引量：4
《Acta Pharmaceutica Sinica B》2022年第11期4122-4137,共16页Fanxiang Yin Ran Zhao Dhilli Rao Gorja Xiaorong Fu Ning Lu Hai Huang Beibei Xu Hanyong Chen Jung-Hyun Shim Kangdong Liu Zhi Li Kyle Vaughn Laster Zigang Dong Mee-Hyun Lee 
supported by grant funding from the National Natural Science Foundation of China(81972839,82002620 and 82073075);the Scientific and Technological Project in Henan Province and Henan Provincial Government(Nos.212102310882,and 222102310104,China).
Colorectal cancer(CRC) is the second most common cause of cancer-related death in the world. The pro-viral integration site for Moloney murine leukemia virus 1(PIM1) is a proto-oncogene and belongs to the serine/threo...
关键词：PIM1 FGFR1 Colorectal cancer HCI-48 Targeted therapy Small moleculecompound ofchalcone Patient-derived xenograft model ATPKinase activity 
Discovery of a mammalian FASN inhibitor against xenografts of non-small cell lung cancer and melanoma被引量：4
《Signal Transduction and Targeted Therapy》2022年第9期3206-3209,共4页Danfeng Cao Jie Yang Youchao Deng Meng Su Yeji Wang Xueqiong Feng Yi Xiong Enhe Bai Yanwen Duan Yong Huang 
This work was supported in parts by the National Natural Science Foundation of China(82173688);the Chinese Ministry of Education 111 Project(BP0820034);The science and technology innovation Program of Hunan Province(2021 RC4067);Hunan Provincial Natural Science Foundation of China(2021J130791);the Hunan Provincial Innovation Foundation for Postgraduate(NO.2019zzts332).
Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(...
关键词：METABOLISM MELANOMA Cancer 
Radiosensitization by microRNA30a-5p in a nude mouse model with subcutaneous lung-cancer xenograft
《Oncology and Translational Medicine》2022年第4期155-164,共10页Yuyan Guo Yingtao Cui Xing Bao Yue Ke Hongtao Ren Jiyuan Pan Liping Song Hongbing Ma 
supported by the National Science Fund Project (No. 81872471);the National Natural Science Foundation of China and the Science Foundation of the Second Affiliated Hospital of Xi’an Jiaotong University (No. YJ(QN)202025)
Objective We aimed to observe the radiosensitization effect of mir-30a-5p in a nude mouse model with subcutaneous lung-cancer xenograft and to explore the underlying mechanism.Methods A549 cell lines with either stabl...
关键词：Mir-30a-5p subcutaneous xenografts RADIOSENSITIZATION ATM 
The novel STAT3 inhibitor WZ-2-033 causes regression of human triple-negative breast cancer and gastric cancer xenografts被引量：1
《Acta Pharmacologica Sinica》2022年第4期1013-1023,共11页Yan Zhong Lin Deng Shuo Shi Qiu-yao Huang Shu-min Ou-Yang Jian-shan Mo Kai Zhu Xin-ming Qu Pei-qing Liu Yuan-xiang Wang Xiao-lei Zhang 
This work was supported by the National Natural Science Foundation of China(81973359 and 21977128);Guangdong Basic and Applied Basic Research Foundation(2019A1515011215);Guangzhou Basic and Applied Basic Research Foundation(202002030408 and 202103000097);Grants from the Fundamental Research Funds for the Central Universities,Sun Yat-sen University(2021qntd44);Jilin Province Science and Technology Development Project(20190304046YY and 20200404105YY);National Engineering and Technology Research Center for New Drug Druggability Evaluation(Seed Program of Guangdong Province,2017B090903004);National Major Special Projects for the Creation and Manufacture of New Drugs(2019ZX09301104);Key-Area Research and Development Program of Guangdong Province(2020B1111110003);Guangdong Provincial Key Laboratory of Construction Foundation(2019B030301005)are also appreciated.
Hyperactive signal transducer and activator of transcription 3 (STAT3) signaling is frequently detected in human triple-negative breast cancer (TNBC) and gastric cancer, leading to uncontrolled tumor growth, resistanc...
关键词：STAT3 inhibitor WZ-2-033 TNBC gastric canc 
Approaches to identifying drug resistance mechanisms to clinically relevant treatments in childhood rhabdomyosarcoma
《Cancer Drug Resistance》2022年第1期80-89,共10页Samson Ghilu Christopher L.Morton Angelina V.Vaseva Siyuan Zheng Raushan T.Kurmasheva Peter J.Houghton 
supported by CA23099,NO1-CM42216,UO1CA199297,RO1CA169368,PO1CA165995 and CPRIT RP160716.
Aim:Despite aggressive multiagent protocols,patients with metastatic rhabdomyosarcoma(RMS)have poor prognosis.In a recent high-risk trial(ARST0431),25% of patients failed within the first year,while on therapy and 80%...
关键词：RHABDOMYOSARCOMA patient-derived xenografts combination therapy intrinsic drug resistance acquired drug resistance 
Experimental models of endocrine responsive breast cancer: strengths, limitations, and use
《Cancer Drug Resistance》2021年第4期762-783,共22页Robert Clarke Brandon C.Jones Catherine M.Sevigny Leena A.Hilakivi-Clarke Surojeet Sengupta 
This work was supported by grants from the from the Department of Defense Breast Cancer Research Program(CA171885);from the National Cancer Institute(U01CA184902)to Dr.Clarke.
Breast cancers characterized by expression of estrogen receptor-alpha(ER;ESR1)represent approximately 70%of all new cases and comprise the largest molecular subtype of this disease.Despite this high prevalence,the num...
关键词：Breast cancer experimental models PDX XENOGRAFTS study design 
Arsenic Trioxide Combining Leflunomide Activates Nrf2-ARE-HO-1 Signaling Pathway and Protects Heart Xenografts被引量：1
《Chinese Journal of Integrative Medicine》2021年第10期760-766,共7页WANG Teng-da XU Song-lin YU Zheng-yi Nl Shao-bin ZHANG Cheng JIAO Zhi-xing 
Planning Task of Harbin Applied Technology Research and Development Project,China(No.2017RAQXJ191)。
Objective:To investigate the molecular mechanisms underlying the effects of arsenic trioxide(As_(2)0_(3))in combination with leflunomide on the hamster-to-rat heart xenotransplant.Methods:Transplantation of LVG hamste...
关键词：arsenic trioxide LEFLUNOMIDE Nrf2-ARE-HO-1 signaling pathway inflammation infiltration XENOTRANSPLANTATION 
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