LEFLUNOMIDE

作品数：48被引量：154H指数：8
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相关领域：医药卫生更多>>
相关作者：汤颖娄探奇成彩联王成唐骅更多>>
相关机构：第二军医大学中山大学附属第三医院广州市妇女儿童医疗中心安徽医科大学更多>>
相关期刊：《眼科》《Chinese Journal of Integrative Medicine》《药学进展》《Acta Pharmacologica Sinica》更多>>
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Leflunomide: A versatile additive for defect reduction, enhanced optoelectronic properties and environmental stability of perovskite films
《Nano Research》2024年第4期2628-2637,共10页Dingyue Sun Ming Peng Taijin Wang Longju Yi Shizuo Zhang Feng Liu Gary J.Cheng 
The development of perovskite photoelectric devices with excellent performance is largely dependent on the defects in the perovskite films.To address this issue,a specific drug,leflunomide(LF,C_(12)H_(9)F_(3)N_(2)O_(2...
关键词：LEFLUNOMIDE additive engineering defect passivation perovskite 
Efficacy of TCM Fumigation Using Dampness-and-cold-dispelling Formula Combined with Methotrexate and Leflunomide Treating Rheumatoid Arthritis with Cold-dampness Bi Syndrome
《Clinical Complementary Medicine and Pharmacology》2024年第1期19-25,共7页Yaoting Du Lin Liu Zhenzhen Niu Xihong Guan Bowen Zeng 
This tudy was supported and funded by Science and Technology Project of Jiangxi Provincial Administration of Traditional Chinese Medicine(2021B117).
Background:Rheumatoid arthritis(RA),a chronic autoimmune disease,has a high incidence and disability rate,causing patients significant discomfort.Although several medicines can be effective,they are also associated wi...
关键词：RA Cold-dampness Bi syndrome Traditional Chinese medicine Fumigation therapy 
Leflunomide therapy for adult patients with steroid-dependent minimal change disease or primary focal segmental glomerulosclerosis
《Chinese Medical Journal》2022年第7期866-868,共3页Chenyang Zhao Zhao Cui Yimiao Zhang Fang Wang Xin Wang Xuyang Cheng Liqiang Meng Gang Liu Minghui Zhao 
Natural Science Foundation of China(No.81870486,No.82070732)。
To the Editor:Minimal change disease(MCD)and focal segmental glomerulosclerosis(FSGS)are common histological subtypes of nephrotic syndrome in adults and children.^([1,2])Corticosteroids are the first-line treatment,w...
关键词：PATIENTS SEGMENTAL THERAPY 
Arsenic Trioxide Combining Leflunomide Activates Nrf2-ARE-HO-1 Signaling Pathway and Protects Heart Xenografts被引量：1
《Chinese Journal of Integrative Medicine》2021年第10期760-766,共7页WANG Teng-da XU Song-lin YU Zheng-yi Nl Shao-bin ZHANG Cheng JIAO Zhi-xing 
Planning Task of Harbin Applied Technology Research and Development Project,China(No.2017RAQXJ191)。
Objective:To investigate the molecular mechanisms underlying the effects of arsenic trioxide(As_(2)0_(3))in combination with leflunomide on the hamster-to-rat heart xenotransplant.Methods:Transplantation of LVG hamste...
关键词：arsenic trioxide LEFLUNOMIDE Nrf2-ARE-HO-1 signaling pathway inflammation infiltration XENOTRANSPLANTATION 
Inflammatory abdominal aortic aneurysms treated with leflunomide:an eight-year follow-up case report and literature review
《Journal of Geriatric Cardiology》2021年第10期847-850,共4页Xue-Ping WU Xiao-Ning ZHAO Xiao-Qun ZHU Wei-Ren CHEN 
The inflammatory abdominal aortic an-eurysm(IAAA)is an uncommon variant of aortic aneurysm and represents between 3%and 10%of all abdominal aortic aneurysms(AAA).[1]The pathogenesis and clinical manifesta-tions of IAA...
关键词：AORTIC ORGANS AAA 
Outcome of Leflunomide in the Treatment of Proliferative Lupus Nephritis Compared to Cyclophosphamide
《Journal of Biosciences and Medicines》2021年第3期64-76,共13页Shahida Mullah Muhammad Rafiqul Alam Shamim Ahmed Amanur Rasul Md. Faisal Anirban Kishor Singha A. K. M. Shahidur Rahman Diwakar Manandhar Asif Mahmud Bikram Bir Bajracharya S. M. Shamsuzzaman Rafi Nazrul Islam Md. Rezaul Alam Ferdous Jahan 
Background: Lupus nephritis (LN) is one of the most common presentations of Systemic lupus erythematosus (SLE). Cyclophosphamide is one of the key immunosuppressive agents for the management of LN. Le...
关键词：CYCLOPHOSPHAMIDE LEFLUNOMIDE Lupus Nephritis (LN) Systemic Lupus Erythematosus (SLE) 
A Small-Scale Medication of Leflunomide as a Treatment of COVID-19 in an Open-Label Blank-Controlled Clinical Trial被引量：8
《Virologica Sinica》2020年第6期725-733,共9页Ke Hu Mengmei Wang Yang Zhao Yunting Zhang Tao Wang Zhishui Zheng Xiaochen Li Shaolin Zeng Dong Zhao Honglin Li Ke Xu Ke Lan 
supported by the Science and Technology Key Project on Novel Coronavirus Pneumonia,Hubei Province(project number:2020FCA002 to K.H.);the Application&Frontier Research Program of Wuhan Government(2019020701011463 to K.X.);Taikang Insurance Group Co.,Ltd;Beijing Taikang Yicai Foundation;Special Fund for COVID-19 Research of Wuhan University for their great supports to this work。
We recently reported that inhibitors against human dihydroorotate dehydrogenase(DHODH)have broad-spectrum antiviral activities including their inhibitory efficacies on SARS-CoV-2 replication in infected cells.However,...
关键词：DHODH inhibitors LEFLUNOMIDE Coronavirus disease 2019(COVID-19) Viral shedding time Inflammation 
Clinical efficacy of tocilizumab combined with leflunomide in the treatment of rheumatoid arthritis
《Journal of Hainan Medical University》2019年第18期25-28,共4页Liang AO Jing LI Rui LIU Yu-Hong LIU Shu-Yun WANG 
Science and Technology Research and Development Program of Affiliated Hospital of Yan'an University(2018PT-09).
Objective:To study the clinical efficacy of tocilizumab combined with leflunomide in the treatment of rheumatoid arthritis.Methods:114 patients with rheumatoid arthritis admitted from May 2015 to April 2018 were rando...
关键词：TOCILIZUMAB LEFLUNOMIDE RHEUMATOID ARTHRITIS Clinical efficacy ADVERSE reactions 
来氟米特治疗类风湿关节炎药物基因组学研究进展被引量：5
《中华风湿病学杂志》2018年第5期334-336,共3页郭明慧 吕爽 黄晶 王贵 肖诚 
国家自然科学基金（81373773,81673844）;科技部国际合作项目（2014DFA31490）
来氟米特（leflunomide）是一种具有抗增殖活性的异唑类免疫调节剂，体内活性主要通过其活性代谢产物（A771726）而产生，其作用机制主要是抑制二氢乳清酸脱氢酶（dihydroorotate dehydrogenase，DHODH）的活性。临床上常用于治疗RA、SL...
关键词：来氟米特 药物基因组学 类风湿关节炎 LEFLUNOMIDE 治疗 A771726 抗增殖活性 活性代谢产物 
Effect of Artemisia annua Extract on Treating Active Rheumatoid Arthritis:A Randomized Controlled Trial被引量：2
《Chinese Journal of Integrative Medicine》2017年第7期496-503,共8页YANG Min GUO Ming-yang LUO Yong YUN Ming-dong YAN Jiao LIU Tao XIAO Chang-hong 
Supported by the National Natural Science Foundation of China(No.810726);the Scientific Research Grants Program of Sichuan Provincial Administration of Traditional Chinese Medicine(No.2012-E-063);the"Twelfth Five-Year Plan"Scientific Research Funds Project of Chinese PLA(No.BWS11J067);the Hospital Program Fund for Research Talents(No.2013YG-B007)
Objective：To investigate the effect and safety of the complementary use of the extract of Artemisia annua L.（EAA） on treating active rheumatoid arthritis（RA）. Methods：A randomized controlled clinical trial was p...
关键词：rheumatoid arthritis leflunomide methotrexate Artemisia annua Chinese medicine 
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