supported by the National Key Research and Development Program of China(No.2021YFE0206600);Sichuan Province Science and Technology Support Program(Nos.2021YFSY0008 and 2020YFH0065);the Translational medicine fund of West China Hospital(No.CGZH19002);1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYGD18020/ZYJC18006).
Nasopharyngeal carcinoma(NPC)is a serious and highly invasive epithelial malignancy that is closely associated with Epstein‒Barr virus(EBV).Due to the lack of therapeutic vaccines for NPC,we selected EBV latent membra...
Mega Project of Research on the Prevention and Control of HIV/AIDS,Viral Hepatitis Infectious Diseases[Grant No:2018ZX10102001];the Key Science and Technology Program of Guangxi Zhuang Autonomous Region[Grant No.14124003-3];the National High Technology Research and Development Program of China[Grant No.2007AA021107];and the National Basic Research Program of China[973 Program,Grant No.2011CB504800]。
Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and af...
supported by the Mega Project of Research on the Prevention and Control of HIV/AIDS,Viral Hepatitis Infectious Diseases [2018ZX10711001]
Epstein-Barr virus (EBV) infection is closely associated with nasopharyngeal carcinoma (NPC)and considered one of the major risk factors[1]. A limited number of viral proteins, such as latent membrane proteins (LMP1, ...
目的构建表达EB病毒(Epstein-Barr virus,EBV)潜伏膜蛋白2(LMP2)与绿色荧光蛋白(GFP)的C3-GFP-LMP2肿瘤细胞模型,观察肿瘤形成及LMP2特异性细胞毒性T淋巴细胞(cytotoxic T lymphocyte,CTL)杀伤肿瘤细胞的效果。方法利用Lenti-X HTX慢病...