云南高校图书馆联盟文献共享服务平台- LYN

LYN: 作品数：81被引量：96H指数：5; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：邵建国何红梅陈琳李民苏锐更多>>; 相关机构：西南医科大学南京中医药大学承德医学院附属医院中南大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金江苏省自然科学基金南通市科技局社会发展科技计划项目国家教育部博士点基金更多>>

Aspartoacylase suppresses prostate cancer progression by blocking LYN activation: 《Military Medical Research》2024年第2期180-205,共26页Hong Weng Kang-Ping Xiong Wang Wang Kai-Yu Qian Shuai Yuan Gang Wang Fang Yu Jun Luo Meng‑Xin Lu Zhong‑Hua Yang Tao Liu Xing Huang Hang Zheng Xing-Huan Wang; supported by the Science and Technology Department of Hubei Province Key Project(YYXKNL2022001);the Non-Profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2020-PT320-004);the Hubei Provincial Natural Science Foundation(2021CFB453);the Science,Technology and Innovation Seed Fund of Zhongnan Hospital of Wuhan University(CXPY2020031);the Climbing Program for Medical Talents of Zhongnan Hospital of Wuhan University(PDJH202206,PDJH202208)。; Background:Globally,despite prostate cancer(PCa)representing second most prevalent malignancy in male,the precise molecular mechanisms implicated in its pathogenesis remain unclear.Consequently,elucidating the key mol...; 关键词：Prostate cancer Aspartoacylase LYN JNK AP-1 C-JUN PHOSPHORYLATION

Preliminary Palynostratigraphic Data on the Middle Albian-Lower Cenomanian of the Tarfaya Basin, Southwest Morocco: 《Open Journal of Geology》2024年第4期548-568,共21页Khaoula Chafai Touria Hssaida Wafaa Maatouf Mohamed Z. Yousfi Sara Chakir Soukaina Jaydawi Hanane Khaffou; The Tarfaya-Laayoune-Boujdour basin is of great interest to oil exploration;on this aspect, there has been exploration by the Moroccan National Office of Hydrocarbons and Mining, which has shown indices of oil and/or ...; 关键词：Morocco Tarfaya-Laayoune-Boujdour Basin Albian-Cenomanian Transition Dinoflagellate Cysts PALYNOSTRATIGRAPHY

Periodic Variation Studies of the Two Short Period W UMa-type Eclipsing Binaries: LX Lyn and V0853 Aur: 《Research in Astronomy and Astrophysics》2024年第1期273-284,共12页Xu Zhang Bin Zhang; partly supported by the Joint Research Fund in Astronomy (grant Nos. U1931101, 42364001) under cooperative agreement between the National Natural Science Foundation of China (NSFC) and Chinese Academy of Sciences (CAS);the National Natural Science Foundation of China (NSFC, Grant No. 11933008);the Guizhou Provincial Science and Technology Foundation (grant Nos.[2020]1Y017, ZK[2022]322);the Foundation of Education Bureau of Guizhou Province,China (grant No. KY (2020) 003);partially supported by the Open Project Program of the CAS Key Laboratory of Optical Astronomy,National Astronomical Observatories,Chinese Academy of Sciences;the TESS team for its support。; In this paper,new light curves(LCs) of contact eclipsing binary(CEB) systems LX Lyn and V0853 Aur are presented and analyzed by using the 2015 version of the Wilson-Devinney(W-D) code.In order to explain their asymmet...; 关键词：stars:activity (stars:)binaries(including multiple):close (stars:)binaries:eclipsing (stars:)brown dwarfs stars:evolution stars:formation

苦参碱通过抑制Lyn/Syk信号通路治疗大鼠过敏性哮喘被引量：4: 《免疫学杂志》2023年第10期872-878,共7页范爱欣袁菲唐科毅; 青岛市公共领域科技支撑计划(09-1-1-5-nsh); 目的探讨苦参碱(Mat)调节Lyn/Syk信号通路对过敏性哮喘大鼠免疫功能的影响。方法随机取12只SD大鼠作为对照组(NC组),其余大鼠参考先前文献通过卵清蛋白(OVA)造模。将造模成功的过敏性哮喘大鼠随机平分为Model组、Mat组(100 mg/kg Mat)、...; 关键词：苦参碱 Lyn/Syk信号通路过敏性哮喘免疫功能

miR-496通过调控 LYN对胃癌细胞增殖和凋亡的影响: 《国际外科学杂志》2023年第9期591-595,F0003,F0004,共7页苏锐李英健朱志达赵恩宏; 承德市科技计划项目(202109A186)。; 目的研究miR-496在胃癌细胞中的表达情况, 并探讨其在胃癌细胞增殖和凋亡过程中的作用及机制。方法实时荧光定量PCR(qPCR)检测miR-496在正常胃上皮细胞株和胃癌细胞系AGS、MKN45中的的表达情况。在表达水平最低的AGS细胞中敲低miR-496,...; 关键词：胃肿瘤细胞增殖细胞凋亡 miR-496

茯苓酸调节Lyn/Syk信号通路对哮喘大鼠气道炎症的影响被引量：2: 《免疫学杂志》2023年第9期790-796,共7页王艳梅甘德堃赵润杨梁彦昌; 河南省中医药科学研究专项课题(2019JDZX066);河南省中医院科研项目(2017YJKT10)。; 目的探讨茯苓酸对支气管哮喘大鼠气道炎症及酪氨酸蛋白激酶(Lyn)/脾酪氨酸激酶(Syk)信号通路的影响及其机制。方法建立支气管哮喘大鼠模型,将大鼠分为对照组、哮喘组、Lyn抑制剂PP2组、茯苓酸5 mg/kg组及茯苓酸10 mg/kg组,观察大鼠肺组...; 关键词：茯苓酸支气管哮喘气道炎症 Lyn/Syk信号通路

IP Lyn:A Totally Eclipsing Contact Binary with an Extremely Low Mass Ratio: 《Research in Astronomy and Astrophysics》2023年第8期206-219,共14页Zi-Xuan Yin Zi-Bin Meng Pei-Ru Wu Xu-Dong Zhang Yun-Xia Yu Ke Hu Fu-Yuan Xiang; supported by the Joint Research Funds in Astronomy under a cooperative agreement between the National Natural Science Foundation of China(NSFC)and the Chinese Academy of Sciences(Nos.U1931115 and U2031114);Scientific Research Fund of Hunan Provincial Education Department grant No.22A0099;the support of the staff of the Xinglong 85 cm telescope;partially supported by the Open Project Program of the Key Laboratory of Optical Astronomy,National Astronomical Observatories,Chinese Academy of Sciences。; We present the first photometric and orbital period investigations for a neglected totally eclipsing contact binary IP Lyn.The photometric solutions derived from both ground-based and several surveys'observations sugg...; 关键词：(stars")binaries(including multiple) close-(stars:)binaries eclipsing-stars evolution-stars individual(IP Lyn)

Src heterodimerically activates Lyn or Fyn to serve as targets for the diagnosis and treatment of esophageal squamous cell carcinoma被引量：3: 《Science China(Life Sciences)》2023年第6期1245-1263,共19页Jing Zhang Di Zhao Lingyuan Zhang Yuanfan Xiao Qingnan Wu Yan Wang Jie Chen Qimin Zhan; supported by the National Natural Science Foundation of China (81988101,81830086 and 81972243);CAMS Innovation Fund for Medical Sciences (2019-I2M-5-081);Major Program of Shenzhen Bay Laboratory (S201101004);Guangdong Basic and Applied Basic Research Foundation (2019B030302012);the Fund of“San-ming”Project of Medicine in Shenzhen (SZSM201812088)。; Although Src is one of the oldest and most investigated oncoproteins,its function in tumor malignancy remains to be defined further.In this study,we demonstrated that the inhibition of Src activity by ponatinib effect...; 关键词：esophageal squamous cell carcinoma HETERODIMER Src-family kinase SRC tyrosine phosphorylation

HT Lyn and IR Lyn:Two Semi-detached-type Near-contact Binaries with Stable Orbital Period: 《Research in Astronomy and Astrophysics》2022年第11期161-175,共15页Zi-Bin Meng Hong-Wei Wang Yun-Xia Yu Ke Hu Fu-Yuan Xiang; supported by the Joint Research Funds in Astronomy(U1931115,U2031114 and U1731110)under cooperative agreement between the National Natural Science Foundation of China and the Chinese Academy of Sciences;partially supported by the Open Project Program of the Key Laboratory of Optical Astronomy,National Astronomical Observatories,Chinese Academy of Sciences.; We presented the first photometric and orbital period investigations for two near-contact binaries:HT Lyn and IR Lyn.The light-curves solutions derived from both our ground-based and various surveys’observations sugg...; 关键词：(stars:)binaries(including multiple):close (stars:)binaries:eclipsing stars:evolution stars:individual(HT Lyn IR Lyn)

LYN通过AKT/mTOR信号通路对胃癌细胞增值及凋亡的影响: 《河北医学》2022年第8期1256-1261,共6页苏锐李英健刘鹏赵恩宏; 河北省承德市科学技术研究与发展计划项目,(编号:202109A186)。; 目的:研究LYN在胃癌中的表达量,以及敲低LYN表达对胃癌细胞增殖及凋亡的影响和机制。方法:使用免疫组织化学方法检测LYN在胃癌和癌旁组织的表达;利用脂质体Lipofectamine2000将shRNA-LYN转染到AGS(胃腺癌)细胞中,以未转染的胃癌细胞为...; 关键词：LYN 胃癌细胞增殖细胞凋亡 AKT/mTOR信号通路

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