MECP2

作品数：158被引量：244H指数：7
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相关机构：北京大学第一医院中国科学院大学复旦大学安徽医科大学更多>>
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Rett syndrome-causing mutations compromise MeCP2- mediated liquid—liquid phase separation of chromatin被引量：5
《Cell Research》2020年第5期393-407,共15页Liang Wang Mingli Hu Mei-Qing Zuo Jicheng Zhao Di Wu Li Huang Yongxin Wen Yunfan Li Ping Chen Xinhua Bao Meng-Qiu Dong Guohong Li Pilong Li 
This work was supported by grants from the Ministry of Science and Technology of China(2017YFA0504202 to G.L.,2019YFA0508403 to P.L,2018YFE0203302 to P.C.);the National Natural Science Foundation of China(31525013,31630041 and 31521002 to G.L.,31871443 to P.L.,31871290 to P.C.);The work was also supported by the Chinese Academy of Sciences(CAS)Strategic Priority Research Program(XDB19040202);the CAS Key Research Program on Frontier Science(QYZDY-SSW-SMC020);an HHMI International Research Scholar grant(55008737)to G.L.
Rett syndrome(RTT),a severe postnatal neurodevelopmental disorder,is caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2(MeCP2).MeCP2 is a chromatin organizer regulating gene expression.RTT-...
关键词：MECP2 separation LIQUID 
Loss of MeCP2 in cholinergic neurons causes part of RTT- like phenotypes via α7 receptor in hippocampus被引量：3
《Cell Research》2016年第6期728-742,共15页Ying Zhang Shu-Xia Cao Peng Sun Hai-Yang He Ci-Hang Yang Xiao-Juan Chen Chen-Jie Shen Xiao-Dong Wang Zhong Chen Darwin K Berg Shumin Duan Xiao-Ming Li 
Acknowledgments We are grateful to ZL Qiu （Institute of Neuroscience, Chinese Academy of Sciences） for providing the AAVS/Mecp2 plasmid. We thank AM Bao （Zhejiang University） for technical assistance, and K-XL and JZ for suggestions on this project. This work was supported by the National Natural Science Foundation of China for Distinguished Young Scientists （81225007）, Key Project of the National Natural Science Foundation of China （31430034）, Major Research Plan of the National Natural Science Foundation of China （91432306）, Funds for Creative Research Groups of Chi- na （81221003）, Program for Changjiang Scholars and Innovative Research Team in University, and Fundamental Research Funds for the Central Universities. This work was also sponsored by the Zhejiang Province Program for Cultivation of High-level Health Talents.
Mutations in the X-linked MECP2 gene cause Rett syndrome （RTT）, an autism spectrum disorder characterized by impaired social interactions, motor abnormalities, cognitive defects and a high risk of epilepsy. Here, we...
关键词：MECP2 cholinergic system Rett syndrome RTT-Iike phenotypes 
MeCP2： Making sense of missense in Rett syndrome被引量：3
《Cell Research》2013年第11期1244-1246,共3页Abhishek Banerjee Esmeralda Romero-Loren Mriganka Sur 
Fine scale genomic regulation is critical for maintaining genomic integrity and is often disrupted in neurodevelopmental disorders. An intriguing new study reveals the in- tricate biochemical complexity of de novo pos...
关键词：综合征 蛋白质相互作用 决策 翻译后修饰 发育障碍 基因表达 基因组 染色质 
Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition被引量：19
《Cell Research》2013年第11期1256-1269,共14页Alika K Maunake Iouri Chepelev Kairong Cui Keji Zhao 
Although the function of DNA methylation in gene promoter regions is well established in transcriptional repression, the function of the evolutionarily conserved widespread distribution of DNA methylation in gene body...
关键词：MECP2 splicing chromatin intragenic DNA methylation EPIGENOMICS histone acetylation 
Methyl-CpG binding proteins in the nervous system被引量：7
《Cell Research》2005年第4期255-261,共7页Leah HUTNICK 
Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain(MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional re...
关键词：MECP2 MBD proteins DNA methylation neuronal differentiation chromatin remodeling gene silencing histone modification. 
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