This work was supported by grants from the National Basic Research Program(973 Program)(No.2014CB542300);the National Natural Science Foundation of China(Grant Nos.31200969,31200874,81101330,31271378,and 81250044);the National Science Fund for Distinguished Young Scholars(81025019);the Natural Science Foun-dation of Jiangsu Province(BK2011013 and BK2012014);the Research Fund for the Doctoral Program of Higher Education of China(20120091120044).
Tumor-associated macrophages(TAMs)mostly exhibit M2-like(alternatively activated)properties and play posi-tive roles in angiogenesis and tumorigenesis.Vascular en-dothelial growth factor(VEGF)is a key angiogenic facto...