financially supported by the National Natural Science Foundation of China (22175086, 22005137, 22205098, and 82201992);the Natural Science Foundation of Jiangsu Province (BK20200321 and BK20210681);the Postdoctoral Research Foundation of Jiangsu Province (2021K007A);China Postdoctoral Science Foundation (2021M700067);the National Postdoctoral Program for Innovative Talents (BX20200161);the Program for Innovative Talents and Entrepreneurs in Jiangsu (JSSCTD202138);the Fundamental Research Funds for the Central Universities (021314380234);the Natural Science Foundation of Nanjing University of Chinese Medicine (XPT82201992)。