supports by the Natural Science Foundation of China (No.51120135001,20934003);the National Basic Research Program of China (No.2011CB606203);the Ph.D. Programs Foundation of Ministry of Education of China (No.20100101120034,20110101130005);“Qianjiang” outstanding researcher funding of Zhejiang Province (No.J20110541);Department of Education of Zhejiang Province (No.Z201018687)