程慧雯

作品数：2被引量：1H指数：1
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供职机构：上海大学更多>>
发文主题：ROPIVACAINEBMK_ITNAV1.5NAV1SUBTYPES更多>>
发文领域：医药卫生生物学更多>>
发文期刊：《Neuroscience Bulletin》更多>>
所获基金：上海市自然科学基金国家自然科学基金更多>>
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Pharmacological modulation of brain Nav1.2 and cardiac Nav1.5 subtypes by the local anesthetic ropivacaine被引量：1
《Neuroscience Bulletin》2010年第4期289-296,共8页程慧雯 杨宏天 周京晶 吉永华 朱红艳 
supported by the National Basic Research Development Program of China(No. 2006CB500801,2010CB529806);the National Natural Science Foundation of China(No.30900422);the Natural Science Foundation of Shanghai Municipality,China(No.08JC1409500);State Key Laboratory of Medical Neurobiology,Fudan University(No.09-02);National Laboratory of Biomacro-molecules,Institute of Biophysics,Chinese Academy of Sciences(No.O5SY021097)
Objective The present study was aimed to investigate the pharmacological modulatory effects of ropivacaine,an amide-type local anesthetic,on rat Nav1.2（rNav1.2）and rNav1.5,the two Na＋channel isoforms heterologously...
关键词：ROPIVACAINE local anesthetic drug Na＋channel subtype-sensitivity electrophysiological recording 
Deglycosylation altered the gating properties of rNav1.3:glycosylation/deglycosylation homeostasis probably complicates the functional regulation of voltage-gated sodium channel
《Neuroscience Bulletin》2008年第5期283-287,共5页徐清 程慧雯 何慧琼 刘志睿 贺明 杨宏天 周智磊 吉永华 
the National Basic Research Development Program of China (No. 2006CB500801).
Objective To examine the effect of deglycosylation on gating properties of rNav1.3. Methods rNav1.3 was expressed in Xenopus oocyte, with glycosylation inhibition by using tunicamycin. Two-electrode voltage clamp was ...
关键词：rNav1.3 voltage-gated sodium channel GLYCOSYLATION two-electrode voltage clamp Xenopus oocyte 
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