funded by Merck and the Yale Cancer Center;the Department of Defense through the Lung Cancer Research Program X81XWH-15-1-0203(S.Goldberg,PI)and W81XWH-16-1-0160(K.Schalper,PI);NIH grants Yale SPORE in Lung Cancer P50CA196530(R.Herbst,PI);R01 CA158167(H.Kluger and G.Desir Pis);K24CA172123(H.Kluger,PI);Yale SPORE in Skin Cancer P50 CA121974(M.Bosenberg and H.Kluger,Pis);R01 CA204002(L.Jilaveanu,PI);the Lung Cancer Research Foundation-LUNGevity and Melanoma Research Alliance,Award«308721(L.Jilaveanu,PI);Stand UpTo Cancer-American Cancer Society Lung Cancer Dream Team Translational Research Grants SU2C-AACR-DT17-15(P.Janne,A.Shaw,J.Wolchok,Pis);SU2C-AACR-DT22-17(L.Diaz,PI);the J.Aron Charitable Foundation(S.Goldberg).
背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(ce...
1文献来源研究一:Hellmann MD,Ciuleanu TE,Pluzanski A,et al.Nivolumab plus Ipilimumab in lung cancer with a high tumor mutational burden[J].N Engl J Med,2018,378(22):2093-2104.研究二:Hellmann MD,Paz-Ares L,Bernabe Caro ...