Immune checkpoint inhibitors are today an immense hope in the management of cancers. However, since their widespread use, many cases of insulin-requiring diabetes appearing suddenly, as fulminant diabetes have been re...
Dear Editor,Collecting duct carcinoma(CDC)or Bellini carcinoma originates in the distal collecting ducts.CDC is a markedly aggressive subtype of renal cell carcinoma and accounts for less than 1%of all renal cell carc...
supported by the Fundamental Research Funds for the Central Universities(3332018070);the National Key Basic Research Development Plan(2018YFC1312105);the Beijing Natural Science Foundation(J20010).
The recent research published in The New England Journal of Medicine by Y.Doki et al.has reported the interim findings from the CheckMate 648,which is an international,multi-center,openlabel,and randomized phase 3 cli...
Checkpoint inhibitors, a subset of immunotherapies, are effective treatment modalities for cancers such as melanoma. However, they are not without possible adverse effects. Drug-induced reactions may present with simi...
Malignant pleural mesothelioma(MPM) is the most common type of malignant mesothelioma. It is a rare tumor linked to asbestos exposure and is associated with a poor prognosis. Until very recently, patients with advance...
The therapeutic landscape for advanced clear cell renal cell carcinoma(ccRCC)is rapidly evolving with improved knowledge of the biology of disease leading to the incorporation of a variety of antiangiogenic agents and...
Pancreatic cancer is one of the most aggressive cancers with a high mortality rate even among patients with early-stage disease.Although recent studies with novel therapeutic approaches have led to modest improvement ...
BACKGROUND Colitis is one of the immune-related side effects of immunotherapy.Usually,such type of side effect was reported to develop within a few weeks of treatment initiation,our case started within a few days.CASE...
1文献来源研究一:Hellmann MD,Ciuleanu TE,Pluzanski A,et al.Nivolumab plus Ipilimumab in lung cancer with a high tumor mutational burden[J].N Engl J Med,2018,378(22):2093-2104.研究二:Hellmann MD,Paz-Ares L,Bernabe Caro ...