Immune checkpoint inhibitors induced colitis, stay vigilant: A case report  

作　　者：Suha Abu Khalaf Abdulmajeed Albarrak Mohamad Yousef Veysel Tahan 

机构地区：[1]Department of Internal Medicine,University of Missouri,Columbia,MO 65212,United States [2]Department of Internal Medicine,College of Medicine,Qassim University,Buraydah 81999,Saudi Arabia [3]Division of Gastroenterology and Hepatology,University of Missouri,Columbia,MO 65212,United States

出　　处：《World Journal of Gastrointestinal Oncology》2020年第6期699-704,共6页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：BACKGROUND Colitis is one of the immune-related side effects of immunotherapy.Usually,such type of side effect was reported to develop within a few weeks of treatment initiation,our case started within a few days.CASE SUMMARY We present a case of a 37-year-old gentleman with bright red loose stools,abdominal pain,and tenesmus.A diagnosis of colitis was made based on endoscopic and histologic findings.Treatment was thereafter continued with oral steroids and discontinuation of the immunotherapy medications.Symptoms resolved after starting the treatment and the patient continued to be symptomfree on subsequent follow-up.The unique about this case report is that the patient developed bloody diarrhea within five days of the 1st immunotherapy cycle,and the patient was on combined ipilimumab and nivolumab.CONCLUSION Immunotherapy related complications might occur within days from being on immunotherapy;we need more research to open the way for future pathological and clinical research to further understand the pathophysiology behind it.

关 键 词：Immunotherapy COLITIS MELANOMA Case report IPILIMUMAB Hepatitis 

分 类 号：R574.62[医药卫生—消化系统]