王晓锋

作品数：3被引量：0H指数：0
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供职机构：北京大学更多>>
发文主题：SIRNA缀合修饰寡核苷酸药物开发更多>>
发文领域：医药卫生更多>>
发文期刊：《Journal of Chinese Pharmaceutical Sciences》更多>>
所获基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Serum stability enhancement of siRNA caused by peptide conjugation at 3'-terminus of sense strand
《Journal of Chinese Pharmaceutical Sciences》2014年第4期215-219,共5页邹朗 黄野 王晓锋 马元 刘洋 关注 张礼和 杨振军 
Ministry of Science and Technology of China(Grant No.2012CB720604);National Natural Science Foundation of China(Grant No.20932001)
RNA interference has been widely used for gene therapy of various infectious diseases and malignant tumors. However, its poor stability in serum has limited further clinic application. Here, we found that stability of...
关键词：SIRNA Serum stability Peptide conjugation NUCLEASES 
Modification of oligonucleotides by isonucleosides incorporation and peptides conjugation
《Journal of Chinese Pharmaceutical Sciences》2012年第6期499-508,共10页黄野 王晓锋 杨振军 张礼和 
National Natural Science Foundation (Grant No.20932001);the Ministry of Science and Technology (Grant No.2012CB720604)
Synthetic oligonucleotides including antisense oligonucleotides and siRNA have shown promising therapeutic potential.However,to realize the therapeutic potential of synthetic oligonucleotides,many obstacles have to be...
关键词：Synthetic oligonucleotide Isonucleoside Cell penetrating peptide SIRNA 
Cell penetrating peptides and their applications in siRNA delivery
《Journal of Chinese Pharmaceutical Sciences》2009年第2期99-105,共7页王晓锋 刘洋 王卓 杨振军 张礼和 
Given its ability to knock down essentially any gene of interest, siRNA has been one of the promising candidates for gene therapy. However, like other nucleic-acid-based drugs, its poor cellular uptake poses a major c...
关键词：SIRNA Cell penetrating peptides （CPPs） Delivery 
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