NUCLEASES

作品数：36被引量：585H指数：8
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相关领域：生物学更多>>
相关作者：谷峰葛香连王晓锋黄野张礼和更多>>
相关机构：温州医科大学北京大学更多>>
相关期刊：《The Innovation》《Science Bulletin》《Bioactive Materials》《Journal of Chinese Pharmaceutical Sciences》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划重庆市自然科学基金更多>>
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Structure-specific nucleases in genome dynamics and strategies for targeting cancers
《Journal of Molecular Cell Biology》2024年第5期3-18,共16页Haitao Sun Megan Luo Mian Zhou Li Zheng Hongzhi Li R.Steven Esworthy Binghui Shen 
This work was supported by National Institutes of Health(NIH)/National Cancer Institute(NCI)grants(R01CA073764,R01CA085344,and R01CA233664 to B.S.and R50CA211397 to L.Z.);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(CIFMS,2023-I2M-3-006 to H.S.).
Nucleases are a super family of enzymes that hydrolyze phosphodiester bonds present in genomes.They widely vary in substrates,causing differentiation in cleavage patterns and having a diversified role in maintaining g...
关键词：structure-specific nucleases DNA replication nuclease inhibitors synthetic lethality 
Characterization of argonaute nucleases from mesophilic bacteria Pseudobutyrivibrio ruminis
《Bioresources and Bioprocessing》2024年第1期1244-1256,共13页Xiaoyi Xu Hao Yang Huarong Dong Xiao Li Qian Liu Yan Feng 
supported by the Ministry of Science and Technology(2020YFA0907700);National Natural Science Foundation of China(31770078,32270051);Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University(21TQ1400204).
Mesophilic Argonautes(Agos)from microbial resources have received significant attention due to their potential applications in genome editing and molecular diagnostics.This study characterizes a novel Ago from Pseudob...
关键词：Pseudobutyrivibrio ruminis Argonaute Mesophilic Argonaute Prokaryotic Argonaute ENDONUCLEASE DNA cleavage 
Nucleases in gene-editing technologies:past and prologue被引量：1
《National Science Open》2023年第5期25-56,共32页Dan-Yuan Li Long-Qi Li Jun-Jie Gogo Liu 
supported by the Ministry of Agriculture and Rural Affairs of China;the National Natural Science Foundation of China(32150018);start-up funds from Tsinghua University,Beijing(J.J.G.L.)
In recent decades,gene-editing technologies,typically based on deoxyribonucleases to specifically modify genomic sequences,have dramatically remodeled various aspects of life sciences,including fundamental research,br...
关键词：gene editing CRISPR ZFN TALEN meganuclease novel gene-editing system 
A programmable pAgo nuclease with RNA target-cleavage specificity from the mesophilic bacterium Verrucomicrobia
《Acta Biochimica et Biophysica Sinica》2023年第8期1204-1212,共9页Qi Liu Wanping Chen Yue Zhang Fengyang Hu Xiaoman Jiang Fei Wang Yang Liu Lixin Ma 
supported by the grants from the China National Key Research and Development(R&D)Program(No.2021YFC2100100);the Wuhan Science and Technology Bureau Knowledge Innovation Special Dawning Program(No.2022020801020326);the Postdoctoral Innovation Project of Shandong Province(No.SDCX-ZG-202203010);the China Postdoctoral Science Foundation(No.2022M721074).
Argonaute(Ago)proteins are conserved programmable nucleases present in eukaryotes and prokaryotes and provide defense against mobile genetic elements.Almost all characterized pAgos prefer to cleave DNA targets.Here,we...
关键词：RNA target specificity Verrucomicrobia bacterium prokaryotic argonaute programmable nucleases 
Blocking Translation of Oncogenic mRNA
《Journal of Cancer Therapy》2023年第6期233-256,共24页Kelvin N. Christie 
Double-stranded RNA-mediated interference (RNAi), antisense oligonucleotides (ASO), and ribozymes have excellent specificity to their target oncogenic mRNA. They also seem to show great promise when it comes to treati...
关键词：Antisense Oligonucleotides RIBOZYMES PHOSPHOROTHIOATE Double-Stranded RNA-Mediated Interference NUCLEASES 
Synergistic engineering of CRISPR-Cas nucleases enables robust mammalian genome editing被引量：4
《The Innovation》2022年第4期74-82,共9页Yangcan Chen Yanping Hu Xinge Wang Shengqiu Luo Ning Yang Yi Chen Zhikun Li Qi Zhou Wei Li 
supported by the National Key Research and Development Program(2019YFA0110800 and 2020YFA0707900 to W.L.and 2018YFA0108400 and 2019YFA0903800 to Q.Z.);the Strategic Priority Research Programof the Chinese Academy of Sciences(XDA16030403 to W.L.);the National Natural Science Foundation of China(31621004 to Q.Z.and W.L.);and the CAS Project for Young Scientists in Basic Research(YSBR-012 to W.L.).
The naturally occurring prokaryotic CRISPR-Cas systems provide valuable resources for the development of new genome-editing tools.However,the majority of prokaryotic Cas nucleases exhibit poor editing efficiency in ma...
关键词：EDITING engineering MAMMALIAN 
Robust genome and RNA editing via CRISPR nucleases in PiggyBac systems
《Bioactive Materials》2022年第8期313-320,共8页Yuqian Jiang Rachel Catherine Hoenisch Yun Chang Xiaoping Bao Craig E.Cameron Xiaojun Lance Lian 
supported by NIH R21EB026035(X.L.L.);NIH R21AI149312(C.E.C.,and X.L.L.);NSF CBET-1943696(X.L.L.);Penn State startup funding to X.L.L.
CRISPR/Cas-mediated genome editing in human pluripotent stem cells(hPSCs)offers unprecedented opportunities for developing in vitro disease modeling,drug screening and cell-based therapies.To efficiently deliver the C...
关键词：CRISPR-Cas9 Genome editing Cas13d RNA editing PiggyBac transposon Human pluripotent stem cells 
Homology-based repair induced by CRISPR-Cas nucleases in mammalian embryo genome editing被引量：4
《Protein & Cell》2022年第5期316-335,共20页Xiya Zhang Tao Li Jianping Ou Junjiu Huang Puping Liang 
the Key Technologies Research and Development Program(2017YFC1001901);the Guangdong Special Support Program(2019BT02Y276);Guangdong Basic and Applied Basic Research Foundation(2018A030313370 and 2021A1515010759);the National Natural Science Foundation of China(31971365);the Guangzhou Science and Technology Project(201803010020).
Recent advances in genome editing,especially CRISPR-Cas nucleases,have revolutionized both laboratory research and clinical therapeutics.CRISPR-Cas nucleases,together with the DNA damage repair pathway in cells,enable...
关键词：homology-based repair(HBR) genome editing disease modeling EMBRYO precision medicine 
Cautious optimism in anticipation of hepatitis B curative therapies
《World Journal of Virology》2022年第4期212-215,共4页Alla Turshudzhyan Micheal Tadros 
Despite relative effectiveness of current hepatitis B therapies,there is still no curative agents available.The new emerging approaches hold promise to achieve cure and loss of hepatitis B surface antigen.Studies or c...
关键词：Hepatitis B Hepatitis B virus Hepatitis B virus entry inhibitor Bulevirtide Transcription activator-like effector nucleases Zinc-finger nucleases Clustered regularly interspaced short palindromic repeats-associated 9 Nucleocapsid assembly modulators Hepatitis B virus transcription inhibitors Hepatitis B surface antigen release inhibitors 
Genome engineering and disease modeling via programmable nucleases for insulin gene therapy;promises of CRISPR/Cas9 technology被引量：2
《World Journal of Stem Cells》2021年第6期485-502,共18页Yunus E Eksi Ahter D Sanlioglu Bahar Akkaya Bilge Esin Ozturk Salih Sanlioglu 
the Akdeniz University Scientific Research Commission and the Scientific and Technological Research Council of Turkey,No.TUBITAK-215S820.
Targeted genome editing is a continually evolving technology employing programmable nucleases to specifically change,insert,or remove a genomic sequence of interest.These advanced molecular tools include meganucleases...
关键词：Programmable nucleases CRISPR/Cas9 Stem cells Disease modeling DIABETES Insulin gene therapy 
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