云南高校图书馆联盟文献共享服务平台- RIBOZYMES

RIBOZYMES: 作品数：15被引量：26H指数：2; 导出分析报告; 相关领域：生物学医药卫生更多>>; 相关作者：祁国荣更多>>; 相关机构：中国科学院上海生命科学研究院更多>>; 相关期刊：《生物化学与生物物理进展》《Genomics, Proteomics & Bioinformatics》《Chinese Journal of Cancer Research》《Journal of Cancer Therapy》更多>>; 相关基金：国家自然科学基金广东省自然科学基金更多>>

Evaluating Performance of Different RNA Secondary Structure Prediction Programs Using Self-cleaving Ribozymes: 《Genomics, Proteomics & Bioinformatics》2024年第3期29-41,共13页Fei Qi Junjie Chen Yue Chen Jianfeng Sun Yiting Lin Zipeng Chen Philipp Kapranov; supported by the National Natural Science Foundation of China(Grant No.32000462 to Fei Qi,Grant No.32170619 to Philipp Kapranov;and Grant No.32201055 to Yue Chen);the Research Fund for International Senior Scientists from the National Natural Science Foundation of China(Grant No.32150710525 to Philipp Kapranov);the Natural Science Foundation of Fujian Province,China(Grant No.2020J02006 to Philipp Kapranov);the Scientific Research Funds of Huaqiao University,China(Grant No.22BS114 to Fei Qi,Grant No.21BS127 to Yue Chen,and Grant No.15BS101 to Philipp Kapranov).; Accurate identification of the correct,biologically relevant RNA structures is critical to understanding various aspects of RNA biology since proper folding represents the key to the functionality of all types of RNA ...; 关键词：RNA secondary structure RNA secondary structure prediction RIBOZYME Deep learning PSEUDOKNOT

Blocking Translation of Oncogenic mRNA: 《Journal of Cancer Therapy》2023年第6期233-256,共24页Kelvin N. Christie; Double-stranded RNA-mediated interference (RNAi), antisense oligonucleotides (ASO), and ribozymes have excellent specificity to their target oncogenic mRNA. They also seem to show great promise when it comes to treati...; 关键词：Antisense Oligonucleotides RIBOZYMES PHOSPHOROTHIOATE Double-Stranded RNA-Mediated Interference NUCLEASES

The Possibility of Nucleic Acids to Act as Anti-Viral Therapeutic Agents—A Review: 《Open Journal of Medical Microbiology》2021年第3期198-248,共51页Md. Selim Reza Farzana Mim Mohammad Rezaul Quader Mohammad Jahidur Rahman Khan Md. Sabir Hossain Kazi Rasel Uddin Salina Akter Sharmin Rahman Sumon Roy Md. Abdullah Rumman; For just about 30 years, researchers have considered the likelihood to utilize nucleic acids as antiviral therap...; 关键词：Antisense Oligonucleotides Aptamers RIBOZYMES Deoxyribozymes RNA Interference

A ribonucleopeptide world at the origin of life: 《Journal of Systematics and Evolution》2018年第1期1-13,共13页Nizar Y. Saad; The structural flexibility of RNA and its ability to store genetic information has led scientists to postulate that RNA could be the key molecule for the development of life on Earth, further leading to formulate the ...; 关键词：amino acids POLYPEPTIDES PROTEINS ribonucleopeptides RIBOZYMES RNA world.

Self-cleaving ribozymes enable the production of guide RNAs from unlimited choices of promoters for CRISPR/Cas9 mediated genome editing被引量：15: 《Journal of Genetics and Genomics》2017年第9期469-472,共4页Yubing He Tao Zhang Ning Yang Meilian Xu Lang Yan Lihao Wang Rongchen Wang Yunde Zhao; supported by a National Transgenic Science and Technology Program (2016ZX08010002)to R.W.;a startup fund from the Huazhong Agricultural University; Development of tools for targeted modifications of specific DNA sequences in plants is of great importance to basic plant biology research as well as crop improvement.The ability to cut DNA at specific locations in th...; 关键词：RGR Self-cleaving ribozymes enable the production of guide RNAs from unlimited choices of promoters for CRISPR/Cas9 mediated genome editing

Ribozymes and the mechanisms that underlie RNA catalysis被引量：2: 《Frontiers of Chemical Science and Engineering》2016年第2期178-185,共8页Timothy J. Wilson Yijin Liu David M. J. Lilley; Ribozymes are widespread, and catalyze some extremely important reactions in the cell. Mechanistically most fall into one of two classes, using either metal ions or general acid-base catalysis. The nucleolytic ribozym...; 关键词：RNA catalysis RNA structure catalytic mechanism

Host RNA circles and the origin of hepatitis delta virus被引量：2: 《World Journal of Gastroenterology》2014年第11期2971-2978,共8页John M Taylor; Recent reports show that many cellular RNAs are processed to form circular species that are relatively abundant and resistant to host nucleases.In some cases,such circles actually bind host microRNAs.Such depletion of...; 关键词：Hepatitis B virus Hepatitis delta virus Circular RNA RIBOZYMES MicroRNA

Ribozymes:an anti-viral agent: 《Asian Pacific Journal of Tropical Medicine》2008年第2期76-82,共7页Asad U.Khan Shahper N.Khan; The discovery that RNA can act as an enzyme led Thomas Cech to win the Nobel Prize in Chemistry and led immediately to the next wave of attempts to find an effective RNA-based therapy.The tantalizing idea that RNA enz...; 关键词：RIBOZYME MOLECULAR tool GENE THERAPY

In Vitro Construction of Effective M1GS Ribozymes Targeting HCMV UL54 RNA Segments被引量：4: 《Acta Biochimica et Biophysica Sinica》2005年第3期210-214,共5页Yun-ZhenSU Hong-JianLI Yue-QinLI Hao-JunCHEN Dong-ShengTANG XinZHANG HongJIANG Tian-HongZHOU; This work was supported by the grants from the National Natural Science Foundation of China(No.30370776);the Natural Science Foundation of Guangdong Province(36703,021162 and 000718); Seven sequence-specific ribozymes(M1GS RNAs)derived in vitro from the catalytic RNA subunit of Escherichia coli RNase P and targeting the mRNAs transcribed by the UL54 gene encoding the DNA polymerase of human cytomeg...; 关键词：ribonuclease P (RNase P) guide sequence HCMV DNA polymerase

GENE THERAPY USING RETROVIRAL VECTOR OF bcr-abl SPECIFIC MULTI-UNIT RIBOZYMES COULD INHIBIT CML CELL GROWTH AND INDUCE APOPTOSIS被引量：1: 《Chinese Journal of Cancer Research》2003年第3期167-171,共5页冯琦孙凯赵永同张涛尚振川王莎王玮赵宁颜真韩苇张英起孙秉中; National Natural Science Foundation of China (No. 39670330).; Objective: To investigate the in vitro cleavage ability and effects on apoptosis and cell growth of the bcr-abl fusion gene specific multi-unit ribozymes. Methods: Three fusion point specific ribozymes were designed ...; 关键词：Chronic myelogenous leukemia BCR-ABL RIBOZYME Gene therapy

RIBOZYMES