RIBOZYME

作品数：143被引量：286H指数：9
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Evaluating Performance of Different RNA Secondary Structure Prediction Programs Using Self-cleaving Ribozymes
《Genomics, Proteomics & Bioinformatics》2024年第3期29-41,共13页Fei Qi Junjie Chen Yue Chen Jianfeng Sun Yiting Lin Zipeng Chen Philipp Kapranov 
supported by the National Natural Science Foundation of China(Grant No.32000462 to Fei Qi,Grant No.32170619 to Philipp Kapranov;and Grant No.32201055 to Yue Chen);the Research Fund for International Senior Scientists from the National Natural Science Foundation of China(Grant No.32150710525 to Philipp Kapranov);the Natural Science Foundation of Fujian Province,China(Grant No.2020J02006 to Philipp Kapranov);the Scientific Research Funds of Huaqiao University,China(Grant No.22BS114 to Fei Qi,Grant No.21BS127 to Yue Chen,and Grant No.15BS101 to Philipp Kapranov).
Accurate identification of the correct,biologically relevant RNA structures is critical to understanding various aspects of RNA biology since proper folding represents the key to the functionality of all types of RNA ...
关键词：RNA secondary structure RNA secondary structure prediction RIBOZYME Deep learning PSEUDOKNOT 
Mitochondrial transport of catalytic RNAs and targeting of the organellar transcriptome in human cells
《Journal of Molecular Cell Biology》2023年第8期40-53,共14页PawełGłodowicz Konrad Kuczynski Romain Val AndréDietrich Katarzyna Rolle 
supported by a grant from the Polish Medical Research Agency(2021/ABM/05/00004);The research was further funded by grants from the Polish National Science Centre(2016/21/N/NZ1/00564);the French State Program‘Investments for the future’(LABEX ANR-11-LABX-0057_MITOCROSS and ANR-10-LABX-0040-SPS);the French National Research Agency(ANR-06-MRAR-037-02 and ANR-09-BLAN-0240-01);R.V.was supported by a fellowship from CNRS and the French Région Alsace.
Mutations in the small genome present in mitochondria often result in severe pathologies.Different genetic strategies have been explored,aiming to rescue such mutations.A number of these strategies were based on the c...
关键词：human cells MITOCHONDRIA RIBOZYME RNA trafficking transcriptome manipulation tRNA-like structure 
The group of Professor Zhenjun Yang has made continuous progress in the research and development of RNA drugs and vaccines
《Journal of Chinese Pharmaceutical Sciences》2021年第11期934-936,共3页无 
核酸是一类能够贮存遗传信息的重要生物分子,其自身及所编码的功能蛋白参与许多生命过程。用以调控基因水平生理过程及疾病治疗的多种功能寡核苷酸是当前的研究热点,包括反义核酸(ASOs)、小干扰RNA(siRNA)、miRNA(microRNA)、核酶(riboz...
关键词：疫苗研发 核酸适配体 反义核酸 生物分子 功能蛋白 RIBOZYME 二核苷酸 寡核苷酸 
杨静华:探索生命编码的秘密
《科学中国人》2018年第18期20-25,共6页刘佳(本刊记者) 
杨静华最早师从于著名的分子进化学家、蒙特利尔大学Bob Cedergren教授,从事催化核糖核酸(ribozyme)结构和功能的研究。1988年在Cedergren教授的推荐下认识了著名诺贝尔奖得主、哈佛大学Walter Gilbert教授,第一次了解到RNA生命起源学...
关键词：生命起源 编码过程 RIBOZYME 分子生物学 诺贝尔奖得主 WALTER 哈佛大学 蒙特利尔 
Folding Kinetics of HDV Ribozyme with C13A:G82U and A16U:U79A Mutations被引量：1
《Wuhan University Journal of Natural Sciences》2015年第5期421-429,共9页ZOU Yanjuan WANG Yujie GONG Sha ZHANG Wenbing 
Supported by the National Natural Science Foundation of China(31270761)
Gene mutations influence the folding kinetics of hepatitis delta virus （HDV） ribozyme. In this work, we study the effect of the double mutation on the folding kinetics of HDV ribozyme. By using the master equation m...
关键词：hepatitis delta virus （HDV） ribozyme master equation method folding kinetics recursive search 
Gene therapeutic approaches to inhibit hepatitis B virus replication被引量：2
《World Journal of Hepatology》2015年第2期150-164,共15页Maren Gebbing Thorsten Bergmann Eric Schulz Anja Ehrhardt 
Supported by The Else-Kröner-Fresenius-Foundation(EKFS)and the UWH Forschungsförderung.
Acute and chronic hepatitis B virus(HBV) infections remain to present a major global health problem. The infection can be associated with acute symptomatic or asymptomatic hepatitis which can cause chronic inflammatio...
关键词：Gene therapy Hepatitis B virus Antisense nucleic acid RNA interference Designer nuclease RIBOZYME DNAZYME Dominant negative mutant External guide sequence DNA vaccination 
Self-processing of ribozyme-flanked RNAs into guide RNAs in vitro and in vivo for CRISPR-mediated genome editing被引量：47
《Journal of Integrative Plant Biology》2014年第4期343-349,共7页Yangbin Gao Yunde Zhao 
supported by NIH R01GM068631 to Y.Z
CRISPR/Cas9 uses a guide RNA （gRNA） molecule to execute sequence-specific DNA cleavage and it has been widely used for genome editing in many organisms. Modifications at either end of the gRNAs often render Cas9/gRN...
关键词：CAS9 CRISPR DNA digestion gRNA genome genomeediting in vitro transcription RIBOZYME 
Recombinant adeno-associated virus serotype 9 with p65 ribozyme protects H9c2 cells from oxidative stress through inhibiting NF-κB signaling pathway被引量：5
《Journal of Geriatric Cardiology》2014年第4期311-315,共5页Zhan SUN Yi-Tong MA Bang-Dang CHEN Fen LIU 
the National Natural Sci-ence Foundation of China，China Post-doctoral Science Foundation
Background Oxidative stress is a major mechanism underlying the pathogenesis of cardiovascular disease. It can trigger inflammatory cascades which are primarily mediated via nuclear factor-κB （NF-κB）. The NF-κB t...
关键词：CARDIOMYOCYTES ADENOVIRUS R65 ribozyme Apoptosis NF-κB pathway 
逆转录法筛选mRNA靶点设计核酶对GPA的表达干预实验研究被引量：1
《中国生物工程杂志》2014年第3期84-90,共7页付辉 李菲菲 马琼 付怀秀 崔玉芳 毛建平 
国家自然科学基金资助项目(81072565;30271546)
采用自行设计5'固定3'随机的文库对基因mRNA进行杂交用于逆转录反应以筛选mRNA的寡核苷酸结合靶点。对人I型跨膜糖蛋白—血型糖蛋白A(glycophorin A,GPA)的mRNA筛选了4个反义寡核苷酸可结合靶点,分别设计反义核酸(Antisense),分别加入m...
关键词：血型糖蛋白A mRNA靶点Ribozyme慢病毒K562细胞 
Prospects for nucleic acid-based therapeutics against hepatitis C virus被引量：1
《World Journal of Gastroenterology》2013年第47期8949-8962,共14页Chang Ho Lee Ji Hyun Kim Seong-Wook Lee 
Supported by National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT and Future Planning No.2012M3A9B6055200,No.2013R1A2A2A01004649
In this review,we discuss recent advances in nucleic acid-based therapeutic technologies that target hepatitis C virus(HCV)infection.Because the HCV genome is present exclusively in RNA form during replication,various...
关键词：Hepatitis C virus Nucleic acid-based THERAPEUTICS RIBOZYME APTAMER siRNA ANTISENSE OLIGONUCLEOTIDE 
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