云南高校图书馆联盟文献共享服务平台- PHOSPHOROTHIOATE

PHOSPHOROTHIOATE: 作品数：29被引量：62H指数：4; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：刘锋何昆王娜赵永强何冬梅更多>>; 相关机构：军事医学科学院暨南大学北京大学清华大学更多>>; 相关期刊：《Acta Pharmacologica Sinica》《Science China Chemistry》《World Journal of Gastroenterology》《Chinese Medical Journal》更多>>; 相关基金：国家自然科学基金中国博士后科学基金北京市自然科学基金国家重点基础研究发展计划更多>>

S-(1,3-Dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate (SDDP): A practical electrophilic reagent for the phosphorothiolation of electron-rich compounds: 《Chinese Chemical Letters》2024年第5期151-154,共4页Ze-Yuan Ma Mei Xiao Cheng-Kun Li Adedamola Shoberu Jian-Ping Zou; generous financial support by National Natural Science Foundation of China(No.21472133);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);Key Laboratory of Organic Synthesis of Jiangsu Province(No.KJS1749).; An efficient synthesis of the electrophilic reagent,S-(1,3-dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate(SDDP)is described.Moreover,the synthetic applications of SDDP wherein the transfer of the SP(O)(OEt)_(2) moi...; 关键词：Electrophilic reagent Phosphorothiolation Electrophilic substitution

A rapid nucleic acid detection platform based on phosphorothioate-DNA and sulfur binding domain: 《Synthetic and Systems Biotechnology》2023年第2期213-219,共7页Yuting Shuai Yi Ju Yuanhang Li Dini Ma Lan Jiang Jingyu Zhang Gao-Yi Tan Xueting Liu Shenlin Wang Lixin Zhang Guang Liu; supported by the National Natural Science Foundation of China(31900060);National Key Research and Development Program of China(2020YFA0907800,2022YFC3400200,2022YFA0912200);Natural Science Foundation of Shanghai(20ZR1414500);Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University(21TQ1400204).; Nucleic acid detection plays a key role in diverse diagnosis and disease control.Currently available nucleic acid detection techniques are challenged by trade-offs among speed,simplicity,precision and cost.Here,we des...; 关键词：PHOSPHOROTHIOATE Sulfur binding domain Nucleic acid detection

Blocking Translation of Oncogenic mRNA: 《Journal of Cancer Therapy》2023年第6期233-256,共24页Kelvin N. Christie; Double-stranded RNA-mediated interference (RNAi), antisense oligonucleotides (ASO), and ribozymes have excellent specificity to their target oncogenic mRNA. They also seem to show great promise when it comes to treati...; 关键词：Antisense Oligonucleotides RIBOZYMES PHOSPHOROTHIOATE Double-Stranded RNA-Mediated Interference NUCLEASES

An enhanced method for nucleic acid detection with CRISPR-Cas12a using phosphorothioate modified primers and optimized gold-nanopaticle strip被引量：1: 《Bioactive Materials》2021年第12期4580-4590,共11页Jiaojiao Gong Lijuan Kan Xiuming Zhang Ying He Jiaqiang Pan Liping Zhao Qianyun Li Menghao Liu Jie Tian Sili Lin Zhouyu Lu Liang Xue Chaojun Wang Guanghui Tang; This work was supported by the Discipline Construction Ability Promotion Project of Shenzhen Health and Population Family Planning Commission(NO.SZXJ2018031(Kan L.J.));Sanming Project of Medicine in Shenzhen(NO.SZSM201601062(Zhang X.M.));Shenzhen Key Medical Discipline Construction Fund(NO.SZXK054(Zhang X.M.)).; CRISPR-Cas12a system has been shown promising for nucleic acid diagnostics due to its rapid,portable and accurate features.However,cleavage of the amplicons and primers by the cis-and trans-activity of Cas12a hinders ...; 关键词：CRISPR-Cas12a Onepot Visual detection

The road less traveled:A new phosphorothioate antiviral defense mechanism discovered in Archaea: 《Synthetic and Systems Biotechnology》2019年第3期132-133,共2页Michael S.DeMott Peter C.Dedon; the National Science Foundation of the USA(CHE-1709364);the National Research Foundation of Singapore in the Singapore-MIT Alliance for Research and Technology Antimicrobial Resistance IRG.; The story of phosphorothioate modifications of DNA begins over 50 years ago and has unfolded like Frost's walk in the woods[1].In 1970,Fritz Eckstein synthesized oligonucleotides in which a non-bridging oxygen in the ...; 关键词：SULFUR BACKBONE BRIDGING

PEGylation of therapeutic oligonucletides： From linear to highly branched PEG architectures被引量：1: 《Nano Research》2018年第10期5519-5534,共16页Xueguang Lu Ke Zhang; Financial support by the National Institute of General Medical Sciences Award Number 1R01GM121612-01, the National Science Foundation （CAREER Award Number 1453255）, and the American Chemical Society Petroleum Research Fund （No. PRF 54905-DNI5）, is acknowledged.; PEGylation, the attachment of poly（ethylene glycol）（PEG）, has been adopted to improve the pharmacokinetic properties of oligonucleotide therapeutics for nearly 30 years. Prior efforts mainly focused on the invest...; 关键词：PEGYLATION OLIGONUCLEOTIDE brush polymer ANTISENSE small interfering RNA APTAMER PHOSPHOROTHIOATE

Engineering Novel Molecular Beacon Constructs to Study Intracellular RNA Dynamics and Localization被引量：1: 《Genomics, Proteomics & Bioinformatics》2017年第5期279-286,共8页Zhao Ma Xiaotian Wu Christopher J.Krueger Antony K.Chen; supported by grants from the National Key R&D Program of China (Grant Nos. 2016YFA0501603 and 2016YFA0100702);the National Natural Science Foundation of China (Grant Nos. 31771583 and 81371613);the Beijing Natural Science Foundation (Grant No. 7162114);the 1000 Young Talent Program of China; With numerous advancements in novel biochemical techniques, our knowledge of the role of RNAs in the regulation of cellular physiology and pathology has grown significantly over the past several decades. Nevertheless,...; 关键词：Y-O-methyl RNA PHOSPHOROTHIOATE Molecular beacon RNA dynamics Single-molecule RNAimaging

Depletion of telomerase RNA inhibits growth of gastrointestinal tumors transplanted in mice: 《World Journal of Gastroenterology》2013年第15期2340-2347,共8页Xue-Cheng Sun Jing-Yi Yan Xiao-Lei Chen Ying-Peng Huang Xian Shen Xiao-Hua Ye; Supported by The Natural Science Foundation of Zhejiang Province, No. Y201016273; AIM: To explore effects of telomerase RNA-targeting phosphorothioate antisense oligodeoxynucleotides (PS-ASODN) on growth of human gastrointestinal stromal tumors transplanted in mice. METHODS: A SCID mouse model for ...; 关键词：Gastrointestinal stromal TUMOR PHOSPHOROTHIOATE antisense OLIGONUCLEOTIDES IMATINIB TUMOR inhibitory rate TELOMERASE activity

Convenient synthesis of nucleoside 5'-(α-P-thio)triphosphates and phosphorothioate nucleic acids(DNA and RNA): 《中国科学：化学》2012年第2期215-218,共4页CATON-WILLIAMS Julianne FIAZ Bilal HOXHAJ Rudiona SMITH Matthew; Modified deoxy-and ribo-nucleoside triphosphates are chemically synthesized in multiple steps due to the protection and deprotection of the nucleoside functionalities.To conveniently synthesize the S-modified triphosp...; 关键词：DNA聚合酶 RNA聚合酶核糖核苷化学合成三磷酸硫代 dNTP浓度高效液相色谱法

Convenient synthesis of nucleoside 5'-(α-P-thio)triphosphates and phosphorothioate nucleic acids(DNA and RNA)被引量：3: 《Science China Chemistry》2012年第1期80-89,共10页CATON-WILLIAMS Julianne FIAZ Bilal HOXHAJ Rudiona SMITH Matthew; supported by USA NIH(GM095086);the Georgia Cancer Coalition(GCC) Distinguished Cancer Clinicians and Scientists;USA National Science Foundation(MCB-0824837); Modified deoxy-and ribo-nucleoside triphosphates are chemically synthesized in multiple steps due to the protection and deprotection of the nucleoside functionalities.To conveniently synthesize the S-modified triphosp...; 关键词：sulfur modification S-derivatized nucleic acid nucleoside triphosphates nucleoside phosphorothioates phosphorothioate DNA and RNA DIASTEREOMERS DNA and RNA polymerases

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

PHOSPHOROTHIOATE

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

PHOSPHOROTHIOATE

检索结果分析

下载全文

用户登录

高级检索检索式检索