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Ornithine aspartate effects on bacterial composition and metabolic pathways in a rat model of steatotic liver disease
《World Journal of Hepatology》2024年第5期832-842,共11页Elisa Carolina Lange Pabulo Henrique Rampelotto Larisse Longo Laura Bainy Rodrigues de Freitas Carolina Uribe-Cruz Mario Reis Alvares-da-Silva 
Financiamento e IncentivoàPesquisa from Hospital de Clínicas de Porto Alegre(FIPE/HCPA),No.2020-0037;Coordination for the Improvement of Higher Education Personnel,CAPES/PNPD;and the Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq).
BACKGROUND Metabolic-dysfunction associated steatotic liver disease(MASLD)is a hepatic manifestation of metabolic syndrome.Studies suggest ornithine aspartate(LOLA)as drug therapy.AIM To analyze the influence of LOLA ...
关键词：Animal model Gut microbiota Metabolic-associated steatotic liver disease Metabolic prediction Ornithine aspartate 
LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression
《Translational Neurodegeneration》2024年第1期884-903,共20页Noah Lubben Julia K.Brynildsen Connor M.Webb Howard L.Li Cheryl E.G.Leyns Lakshmi Changolkar Bin Zhang Emily S.Meymand Mia O’Reilly Zach Madaj Daniella DeWeerd Matthew J.Fell Virginia M.Y.Lee Dani S.Bassett Michael X.Henderson 
supported by the Michael J.Fox Foundation for Parkinson’s Research(MJFF)grant 16879(M.X.H)and Aligning Science Across Parkinson’s ASAP-020616 through MJFF;NIH grants:R01-AG077573(D.S.B,M.X.H.);NSF grants PHY-1554488(D.S.B)and BCS-1631550(D.S.B).D.S.B.also acknowledges support from the John D.and Catherine T.MacArthur Foundation,the ISI Foundation,the Alfred P.Sloan Foundation,and the Paul G.Allen Foundation.
Background Mutations in leucine-rich repeat kinase 2(LRRK2)are the most common cause of familial Parkinson’s disease(PD).These mutations elevate the LRRK2 kinase activity,making LRRK2 kinase inhibitors an attractive ...
关键词：G2019S MLi-2 Cell-to-cell spread Transmission Genetic risk MAPT 
Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5被引量：2
《Bone Research》2023年第3期595-606,共12页Cassandra R.Diegel Ina Kramer Charles Moes Gabrielle E.Foxa Mitchell J.McDonald Zachary B.Madaj Sabine Guth Jun Liu Jennifer L.Harris Michaela Kneissel Bart O.Williams 
Proper regulation of Wnt signaling is critical for normal bone development and homeostasis.Mutations in several Wnt signaling components,which increase the activity of the pathway in the skeleton,cause high bone mass ...
关键词：HOMEOSTASIS function mass 
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