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5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers被引量:41
《Cell Research》2017年第10期1243-1257,共15页Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu 
DNA modifications such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are epigenetic marks known to affect global gene efpression in mammals. Given their prevalence in the human genome, close correla...
关键词:5-hydroxymethylcytosine liquid biopsy circulating cell-free DNA cancer biomarker 5hmC-Seal 
Research progress in interface modification and thermal conduction behavior of diamond/metal composites被引量:9
《International Journal of Minerals,Metallurgy and Materials》2022年第2期200-211,共12页Ping Zhu Pingping Wang Puzhen Shao Xiu Lin Ziyang Xiu Qiang Zhang Equo Kobayashi Gaohui Wu 
financially supported by the National Natural Science Foundation of China(Nos.52071117 and 51771063);the Heilongjiang Provincial Science Fund for Distinguished Young Scholars(No.JQ2021E002)。
Diamond/metal composites are widely used in aerospace and electronic packaging fields due to their outstanding high thermal conductivity and low expansion.However,the difference in chemical properties leads to interfa...
关键词:diamond/metal interface modification thermal conductivity computational simulation 
Abscisic acid perception and signaling: structura mechanisms and applications被引量:7
《Acta Pharmacologica Sinica》2014年第5期567-584,共18页Ley Moy NG Karsten MELCHER Bin Tean TEH H Eric XU 
Adverse environmental conditions are a threat to agricultural yield and therefore exert a global effect on livelihood, health and the economy. Abscisic acid (ABA) is a vital plant hormone that regulates abiotic stre...
关键词:abscisic acid abiotic stress ABA receptor plant hormone 
Densification,microstructure and mechanical properties of multicomponent(TiZrHfNbTaMo)C ceramic prepared by pressureless sintering被引量:7
《Journal of Materials Science & Technology》2021年第13期23-28,共6页Wen Zhang Lei Chen Chenguang Xu Wenyu Lu Yujin Wang Jiahu Ouyang Yu Zhou 
financially supported by the National Natural Science Foundation of China(Nos.51972081,51602074,51872061,51621091);Natural Science Foundation of Heilongjiang Province(Grant No.E2016026)。
A multicomponent(TiZrHfNbTaMo)C ceramic has been fabricated by pressureless sintering at temperatures from 2100℃to 2500℃,using an equimolar multicomponent carbide powder synthesized by carbothermal reduction as the ...
关键词:Multicomponent carbide ceramic Pressureless sintering Microstructure Mechanical properties 
Microstructural evolution and thermal conductivity of diamond/Al composites during thermal cycling被引量:7
《International Journal of Minerals,Metallurgy and Materials》2021年第11期1821-1827,共7页Ping-ping Wang Guo-qin Chen Wen-jun Li Hui Li Bo-yu Ju Murid Hussain Wen-shu Yang Gao-hui Wu 
financially supported by the National Natural Science Foundation of China(Nos.1871072,51871073,52171136,51771063,61604086,and U1637201);the China Postdoctoral Science Foundation(Nos.2016M590280 and 2017T100240);the Heilongjiang Postdoctoral Foundation(Nos.LBH-Z16075 and LBH-TZ2014);the Fundamental Research Funds for the Central Universities,China(Nos.HIT.NSRIF.20161 and HIT.MKSTISP.201615).
The microstructural evolution and performance of diamond/Al composites during thermal cycling has rarely been investigated.In the present work,the thermal stability of diamond/Al composites during thermal cycling for ...
关键词:metal-matrix composites DIAMOND STABILITY thermal mismatch stress 
HfC–HfO_(2) modified high/superhigh temperature thermal protection coating for superior hot corrosion resistance and antioxidation performance
《Journal of Advanced Ceramics》2025年第1期177-191,共15页Zhiyun Ye Shuqi Wang Shuang Yu Xinrui Zhao Yongchun Zou Guoliang Chen Lei Wen Lina Zhao Guangxi Zhang Yaming Wang Jiahu Ouyang Dechang Jia Yu Zhou 
support from the National Natural Science Foundation of China(Nos.523B2010,U21B2053,52071114,52301084,and 52001100);the China Postdoctoral Science Foundation(No.2023M730843);the Heilongjiang Touyan Team Program,the Heilongjiang Postdoctoral Science Foundation(No.AUGA4110004823);the Research start-up Fund by HIT are gratefully acknowledged.
With advances in the thrust-weight ratio,the service temperature of gas turbine engines even exceeds 1500℃,which is urgent for the development of high/superhigh-temperature thermal protection systems(TPSs)for long-te...
关键词:thermal protection coating niobium alloys hot corrosion resistance high-temperature oxidation resistance stress release mechanism 
An ionic liquid-assisted strategy for enhanced anticorrosion of low-energy PEO coatings on magnesium–lithium alloy被引量:2
《Journal of Magnesium and Alloys》2024年第6期2380-2396,共17页You Zhang Chuping Chen Haoyue Tian Shuqi Wang Chen Wen Fei Chen 
supported by the Natural Science Founda-tion of Beijing(Grant No.2182017,2202017).
A low-energy plasma electrolytic oxidation(LePEO)technique is developed to simultaneously improve energy efficiency and anti-corrosion.Ionic liquids(1-butyl-3-methylimidazole tetrafluoroborate(BmimBF_(4)))as sustainab...
关键词:Magnesium-lithium alloy Plasma electrolytic oxidation Low energy Ionic liquid Corrosion resistance 
Modular-integrative modeling:a new framework for building brain models that blend biological realism and functional performance被引量:1
《National Science Review》2024年第5期6-9,共4页Mario Senden Sacha J.van Albada Giovanni Pezzulo Egidio Falotico Ibrahim Hashim Alexander Kroner Anno C.Kurth Pablo Lanillos Vaishnavi Narayanan Cyriel Pennartz Mihai A.Petrovici Lea Steffen Tonio Weidler Rainer Goebel 
supported by the European Union’s Horizon 2020 Framework Programme for Research and Innovation(Human Brain Project SGA3,945539).
To cope with the immense complexity of the brain,neuroscientific research often focuses on isolated brain structures or circumscribed perceptual,cognitive or motor functions[1].This reductionist approach overlooks the...
关键词:FUNCTIONAL latter instance 
Oncoprotein LAMTOR5-mediated CHOP silence via DNA hypermethylation and miR-182/miR-769 in promotion of liver cancer growth被引量:1
《Acta Pharmacologica Sinica》2024年第12期2625-2645,共21页Xue Wang Qian-qian Li Yan-xin Tang Ye Li Lu Zhang Fei-fei Xu Xue-li Fu Kai Ye Jia-qi Ma Shi-man Guo Fang-yuan Ma Zhi-yu Liu Xu-he Shi Xian-meng Li Hui-min Sun Yue Wu Wei-ying Zhang Li-hong Ye 
supported by the National Natural Science Foundation of China(82072943 and 82072929).
C/EBP homologous protein(CHOP)triggers the death of multiple cancers via endoplasmic reticulum(ER)stress.However,the function and regulatory mechanism of CHOP in liver cancer remain elusive.We have reported that late ...
关键词:liver cancer CHOP LAMTOR5 lenvatinib DNA methylation miR-182/miR-769 
Dislocation energy and calculation from Peierls stress: a rigorous the lattice theory被引量:5
《Chinese Physics B》2006年第6期1301-1309,共9页王少峰 
Project supported by the National Natural Science Foundation of China (Grant No 10274057).
In the classical Peierls-Nabarro (P-N) theory of dislocation, there is a long-standing contradiction that the stable configuration of dislocation has maximum energy rather than minimum energy. In this paper, the dis...
关键词:dislocation energy Peierls stress lattice theory 
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